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Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications.
ACS Nano. 2020 Jul 08 [Online ahead of print]AN

Abstract

Lanthanide-doped inorganic upconversion nanocrystals (UCNCs) are promising as fluorescent diagnostic and therapeutic agents for in vivo applications ranging from biological imaging to disease theranostics. However, all currently available lanthanide-doped inorganic UCNCs are not biodegradable and thus cannot be harmlessly eliminated from the body of living organism during a reasonable period of time, making their clinical translations nearly impossible. Here, we report a class of red-emitting biodegradable UCNCs based on Yb3+/Er3+-doped inorganic potassium heptafluozirconate (K3ZrF7:Yb/Er) that features a dynamically "soft" crystal lattice containing water-soluble [ZrF7]3- cluster and a K+ cation. The red-emitting K3ZrF7:Yb/Er UCNCs exhibit a pH-dependent biodegradation capability upon exposure to water both in vitro and in vivo, and the rapid biodegradation rate, monitored using the intrinsic red upconversion luminescence, can be tuned particularly in a mild acidic tumor microenvironment (pH ∼5-6). More importantly, the final biodegradation products of K3ZrF7:Yb/Er UCNCs can be excreted from the body of mice in a short period of time with no evidence of toxicity, in stark contrast to the nondegradable β-NaYF4:Yb/Er UCNCs that primarily accumulate in the main organs of mice. These findings described here unambiguously would benefit the future biomedical applications and clinical translations of lanthanide-doped inorganic UCNCs.

Authors+Show Affiliations

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.Fujian Center for Safety Evaluation of New Drug, Fujian Medical University, Fuzhou, Fujian 350122, China.State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. University of the Chinese Academy of Sciences, Beijing 100049, China.State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. University of the Chinese Academy of Sciences, Beijing 100049, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32628445

Citation

Peng, Pengfei, et al. "Biodegradable Inorganic Upconversion Nanocrystals for in Vivo Applications." ACS Nano, 2020.
Peng P, Wu N, Ye L, et al. Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications. ACS Nano. 2020.
Peng, P., Wu, N., Ye, L., Jiang, F., Feng, W., Li, F., Liu, Y., & Hong, M. (2020). Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications. ACS Nano. https://doi.org/10.1021/acsnano.0c02601
Peng P, et al. Biodegradable Inorganic Upconversion Nanocrystals for in Vivo Applications. ACS Nano. 2020 Jul 8; PubMed PMID: 32628445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications. AU - Peng,Pengfei, AU - Wu,Na, AU - Ye,Lixiang, AU - Jiang,Feilong, AU - Feng,Wei, AU - Li,Fuyou, AU - Liu,Yongsheng, AU - Hong,Maochun, Y1 - 2020/07/08/ PY - 2020/7/7/pubmed PY - 2020/7/7/medline PY - 2020/7/7/entrez KW - biodegradable KW - inorganic fluorides KW - lanthanide ion KW - luminescent nanocrystals KW - upconversion JF - ACS nano JO - ACS Nano N2 - Lanthanide-doped inorganic upconversion nanocrystals (UCNCs) are promising as fluorescent diagnostic and therapeutic agents for in vivo applications ranging from biological imaging to disease theranostics. However, all currently available lanthanide-doped inorganic UCNCs are not biodegradable and thus cannot be harmlessly eliminated from the body of living organism during a reasonable period of time, making their clinical translations nearly impossible. Here, we report a class of red-emitting biodegradable UCNCs based on Yb3+/Er3+-doped inorganic potassium heptafluozirconate (K3ZrF7:Yb/Er) that features a dynamically "soft" crystal lattice containing water-soluble [ZrF7]3- cluster and a K+ cation. The red-emitting K3ZrF7:Yb/Er UCNCs exhibit a pH-dependent biodegradation capability upon exposure to water both in vitro and in vivo, and the rapid biodegradation rate, monitored using the intrinsic red upconversion luminescence, can be tuned particularly in a mild acidic tumor microenvironment (pH ∼5-6). More importantly, the final biodegradation products of K3ZrF7:Yb/Er UCNCs can be excreted from the body of mice in a short period of time with no evidence of toxicity, in stark contrast to the nondegradable β-NaYF4:Yb/Er UCNCs that primarily accumulate in the main organs of mice. These findings described here unambiguously would benefit the future biomedical applications and clinical translations of lanthanide-doped inorganic UCNCs. SN - 1936-086X UR - https://www.unboundmedicine.com/medline/citation/32628445/Biodegradable_Inorganic_Upconversion_Nanocrystals_for_In_Vivo_Applications L2 - https://doi.org/10.1021/acsnano.0c02601 DB - PRIME DP - Unbound Medicine ER -
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