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Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review.
Life Sci. 2020 Sep 15; 257:118019.LS

Abstract

Parkinson's disease (PD) is a disease of the human nervous system with an onset, in the sixth and seventh decades of the human life. Chiefly perceived as progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) with the ensued loss of dopamine in the striatum and the presence of Lewy bodies, consisting of α-synuclein agglomeration. In which the neuronal bridge between substantia nigra and striatum plays an advent role in the motor system. Dilapidation of these neurons results in dopamine depletion which in-turn makes hay to PD. Eventually, the etiology and pathogenesis of PD were still on a hike of dilemma. Traditional Chinese medicine (TCM), including Chinese herbal remedies, acupuncture, and manipulative therapies, is commonly used as an adjunctive therapy in different diseases, particularly neurological diseases, in Asian countries. Additionally, TCM might improve the prognoses and the quality of life of patients with PD because it induces less adverse drug reactions. The present review describes research on the various neuroprotective components and herbal extracts from herbal medicines in the context of addressing the effects of PD.

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Authors+Show Affiliations

Chang YM
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Chinese Medicine Department, E-DA Hospital, Kaohsiung, Taiwan; 1PT Biotechnology Co., Ltd., Taichung, Taiwan.
Manoj Kumar M
Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Lu CY
Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Te Tsai C
1PT Biotechnology Co., Ltd., Taichung, Taiwan.
Tsai CC
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Chinese Medicine Department, E-DA Hospital, Kaohsiung, Taiwan.
Liao PH
Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Lin SL
1PT Lukang Chinese Medicine Clinics, Changhua, Taiwan.
Chang CC
Department of Physical Therapy, I-Shou University, Kaohsiung, Taiwan.
Mahalakshmi B
Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam.
Kuo WW
Department of Biological Science and Technology, China Medical University, Taichung, Taiwan. Electronic address: wwkuo@mail.cmu.edu.tw.
Huang CY
Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien 970, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address: cyhuang@mail.cmu.edu.tw.

MeSH

AnimalsBrainCorpus StriatumDisease Models, AnimalDopamineDopaminergic NeuronsHumansMedicine, Chinese TraditionalMiceMice, Inbred C57BLNeuroprotective AgentsParkinson DiseasePars CompactaSubstantia NigraTyrosine 3-Monooxygenasealpha-Synuclein

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32629002

Citation

Chang, Yung Ming, et al. "Parkinson's Disease a Futile Entangle of Mankind's Credence On an Herbal Remedy: a Review." Life Sciences, vol. 257, 2020, p. 118019.
Chang YM, Manoj Kumar M, Lu CY, et al. Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review. Life Sci. 2020;257:118019.
Chang, Y. M., Manoj Kumar, M., Lu, C. Y., Te Tsai, C., Tsai, C. C., Liao, P. H., Lin, S. L., Chang, C. C., Mahalakshmi, B., Kuo, W. W., & Huang, C. Y. (2020). Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review. Life Sciences, 257, 118019. https://doi.org/10.1016/j.lfs.2020.118019
Chang YM, et al. Parkinson's Disease a Futile Entangle of Mankind's Credence On an Herbal Remedy: a Review. Life Sci. 2020 Sep 15;257:118019. PubMed PMID: 32629002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review. AU - Chang,Yung Ming, AU - Manoj Kumar,M, AU - Lu,Cheng You, AU - Te Tsai,Chuan, AU - Tsai,Chin Chuan, AU - Liao,Po Hsiang, AU - Lin,Shu Luan, AU - Chang,Chia Cheng, AU - Mahalakshmi,B, AU - Kuo,Wei Wen, AU - Huang,Chih Yang, Y1 - 2020/07/03/ PY - 2020/04/16/received PY - 2020/06/14/revised PY - 2020/06/24/accepted PY - 2020/7/7/pubmed PY - 2020/9/12/medline PY - 2020/7/7/entrez KW - Dopaminergic KW - Herbal medicines KW - Neuroprotective compounds KW - Parkinson's disease SP - 118019 EP - 118019 JF - Life sciences JO - Life Sci VL - 257 N2 - Parkinson's disease (PD) is a disease of the human nervous system with an onset, in the sixth and seventh decades of the human life. Chiefly perceived as progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) with the ensued loss of dopamine in the striatum and the presence of Lewy bodies, consisting of α-synuclein agglomeration. In which the neuronal bridge between substantia nigra and striatum plays an advent role in the motor system. Dilapidation of these neurons results in dopamine depletion which in-turn makes hay to PD. Eventually, the etiology and pathogenesis of PD were still on a hike of dilemma. Traditional Chinese medicine (TCM), including Chinese herbal remedies, acupuncture, and manipulative therapies, is commonly used as an adjunctive therapy in different diseases, particularly neurological diseases, in Asian countries. Additionally, TCM might improve the prognoses and the quality of life of patients with PD because it induces less adverse drug reactions. The present review describes research on the various neuroprotective components and herbal extracts from herbal medicines in the context of addressing the effects of PD. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32629002/Parkinson's_disease_a_futile_entangle_of_Mankind's_credence_on_an_herbal_remedy:_A_review_ DB - PRIME DP - Unbound Medicine ER -

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