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Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
Neuroimage. 2020 11 01; 221:117132.N

Abstract

BACKGROUND

The natural polyamine spermidine, known to be important for cellular function, decreases during aging. Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting that spermidine may be a preventive approach to delay age-related cognitive decline and possibly even Alzheimer's disease (AD). However, the association of spermidine intake with brain health in humans is still unknown. In this study, we aimed to determine the association between dietary spermidine intake and structural brain measures in older individuals with subjective cognitive decline (SCD) and healthy controls (HC).

METHODS

Dietary spermidine intake and adherence to Mediterranean Diet (MeDi) were assessed by a self-reported food frequency questionnaire in 90 older adults with SCD and 47 HC. Processing of structural MRI data yielded global brain volumes, hippocampal volume, mean and regional cortical thickness, and cortical thickness in a template encompassing AD-vulnerable regions. In exploratory analyses, the association between spermidine intake and structural brain measures was assessed using adjusted and unadjusted linear regression models. Additionally, we tested for differential associations as a function of group. Mediation analyses were performed to examine whether dietary spermidine intake mediates the associations between adherence to MeDi and structural brain measures.

RESULTS

Higher spermidine intake was associated with larger hippocampal volume (standardized β ​= ​0.262, p ​= ​0.002), greater mean cortical thickness (standardized β ​= ​0.187, p ​= ​0.031), and greater cortical thickness in AD-vulnerable brain regions (standardized β ​= ​0.176, p ​= ​0.042), the parietal (standardized β ​= ​0.202, p ​= ​0.020), and temporal lobes (standardized β ​= ​0.217, p ​= ​0.012). No significant differential effect emerged between older adults with SCD and HC. Moreover, a substantial mediating effect of dietary spermidine intake on the associations between adherence to MeDi and structural brain measures was observed.

CONCLUSION

Higher dietary spermidine intake was positively associated with several structural brain measures, irrespective of the presence of SCD, and substantially mediated the relationship of adherence to MeDi and structural brain measures. Our data suggest that higher spermidine intake might be a promising dietary approach to preserve brain health in older adults, a hypothesis currently tested in an interventional trial.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Schwarz C
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. Electronic address: claudia.schwarz@charite.de.
Horn N
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. Electronic address: nora.horn@charite.de.
Benson G
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany; Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: gloria.spielmann-benson@zi-mannheim.de.
Wrachtrup Calzado I
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. Electronic address: isabel.wrachtrup.calzado@web.de.
Wurdack K
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. Electronic address: katharina.wurdack@charite.de.
Pechlaner R
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: raimund.pechlaner@i-med.ac.at.
Grittner U
Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address: ulrike.grittner@charite.de.
Wirth M
German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany. Electronic address: miranka.wirth@dzne.de.
Flöel A
Department of Neurology, University Medicine Greifswald, Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE) Standort Greifswald, Greifswald, Germany. Electronic address: agnes.floeel@med.uni-greifswald.de.

MeSH

AgedAged, 80 and overAgingCerebral CortexCognitive DysfunctionCross-Sectional StudiesDiagnostic Self EvaluationDiet, MediterraneanEatingFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedSpermidine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32629145

Citation

Schwarz, Claudia, et al. "Spermidine Intake Is Associated With Cortical Thickness and Hippocampal Volume in Older Adults." NeuroImage, vol. 221, 2020, p. 117132.
Schwarz C, Horn N, Benson G, et al. Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. Neuroimage. 2020;221:117132.
Schwarz, C., Horn, N., Benson, G., Wrachtrup Calzado, I., Wurdack, K., Pechlaner, R., Grittner, U., Wirth, M., & Flöel, A. (2020). Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. NeuroImage, 221, 117132. https://doi.org/10.1016/j.neuroimage.2020.117132
Schwarz C, et al. Spermidine Intake Is Associated With Cortical Thickness and Hippocampal Volume in Older Adults. Neuroimage. 2020 11 1;221:117132. PubMed PMID: 32629145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. AU - Schwarz,Claudia, AU - Horn,Nora, AU - Benson,Gloria, AU - Wrachtrup Calzado,Isabel, AU - Wurdack,Katharina, AU - Pechlaner,Raimund, AU - Grittner,Ulrike, AU - Wirth,Miranka, AU - Flöel,Agnes, Y1 - 2020/07/03/ PY - 2020/04/22/received PY - 2020/06/19/revised PY - 2020/07/01/accepted PY - 2020/7/7/pubmed PY - 2021/3/2/medline PY - 2020/7/7/entrez KW - Cortical thickness KW - Hippocampal volume KW - Mediterranean Diet KW - Spermidine KW - Subjective cognitive decline SP - 117132 EP - 117132 JF - NeuroImage JO - Neuroimage VL - 221 N2 - BACKGROUND: The natural polyamine spermidine, known to be important for cellular function, decreases during aging. Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting that spermidine may be a preventive approach to delay age-related cognitive decline and possibly even Alzheimer's disease (AD). However, the association of spermidine intake with brain health in humans is still unknown. In this study, we aimed to determine the association between dietary spermidine intake and structural brain measures in older individuals with subjective cognitive decline (SCD) and healthy controls (HC). METHODS: Dietary spermidine intake and adherence to Mediterranean Diet (MeDi) were assessed by a self-reported food frequency questionnaire in 90 older adults with SCD and 47 HC. Processing of structural MRI data yielded global brain volumes, hippocampal volume, mean and regional cortical thickness, and cortical thickness in a template encompassing AD-vulnerable regions. In exploratory analyses, the association between spermidine intake and structural brain measures was assessed using adjusted and unadjusted linear regression models. Additionally, we tested for differential associations as a function of group. Mediation analyses were performed to examine whether dietary spermidine intake mediates the associations between adherence to MeDi and structural brain measures. RESULTS: Higher spermidine intake was associated with larger hippocampal volume (standardized β ​= ​0.262, p ​= ​0.002), greater mean cortical thickness (standardized β ​= ​0.187, p ​= ​0.031), and greater cortical thickness in AD-vulnerable brain regions (standardized β ​= ​0.176, p ​= ​0.042), the parietal (standardized β ​= ​0.202, p ​= ​0.020), and temporal lobes (standardized β ​= ​0.217, p ​= ​0.012). No significant differential effect emerged between older adults with SCD and HC. Moreover, a substantial mediating effect of dietary spermidine intake on the associations between adherence to MeDi and structural brain measures was observed. CONCLUSION: Higher dietary spermidine intake was positively associated with several structural brain measures, irrespective of the presence of SCD, and substantially mediated the relationship of adherence to MeDi and structural brain measures. Our data suggest that higher spermidine intake might be a promising dietary approach to preserve brain health in older adults, a hypothesis currently tested in an interventional trial. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/32629145/Spermidine_intake_is_associated_with_cortical_thickness_and_hippocampal_volume_in_older_adults_ DB - PRIME DP - Unbound Medicine ER -