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A fast and simple approach for the quantification of five anti-hypersensitivity drugs in saliva and urine by portable ion mobility spectrometry based on magnetic graphene oxide dispersive solid phase extraction.
J Pharm Biomed Anal. 2020 Jun 10; 189:113414.JP

Abstract

Fatal road traffic crashes are often related to multifarious risk factors, among which driving under the influence of drugs (DUID) has been reported as a significantly contributing cause. The first worry about the side-effect of influencing driving drugs is central nervous system adverse reaction, and anti-hypersensitivity drugs are a class of drugs with such side effects meanwhile has been widely used for common allergic diseases thus posing a great challenge to road safety and demanding a rapid and efficient method to detect. In this work, a method based on magnetic graphene oxide dispersive solid phase extraction (MGO-D-SPE) combined with ion mobility spectrometry (IMS) was firstly introduced for simultaneous determination of ephedrine, pseudoephedrine, diphenhydramine, promethazine and terfenadine in saliva and urine matrices. The prepared MGO was characterized by Fourier transform infrared (FT-IR) spectroscopy and thermo gravimetric analysis (TGA). Various parameters affecting extraction efficiency as well as instrumental acquisition sensitivity were studied and optimized. Under the optimum experimental conditions, the method was fully validated and the results demonstrated that the proposed method exhibited some advantages, including a good linearity covering large concentration ranges of 51.0-3040 ng ml-1 for five anti-hypersensitivity drugs, and good accuracy was also obtained with high precision (CV% < 5.0 %). LODs and LOQs were 10.2-50.4 ng·mL-1 and 30.6-101.3 ng·mL-1, respectively. Consequently, the MGO-D-SPE-IMS methodology succeeded in building a hitherto unexplored tool for quantifying anti-hypersensitivity drugs in saliva and urine matrices of interest in DUID research field.

Authors+Show Affiliations

Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China.Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050011, China.Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050011, China.Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China. Electronic address: jiangye@hebmu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32629193

Citation

Cui, Yixuan, et al. "A Fast and Simple Approach for the Quantification of Five Anti-hypersensitivity Drugs in Saliva and Urine By Portable Ion Mobility Spectrometry Based On Magnetic Graphene Oxide Dispersive Solid Phase Extraction." Journal of Pharmaceutical and Biomedical Analysis, vol. 189, 2020, p. 113414.
Cui Y, Liu D, Zhao M, et al. A fast and simple approach for the quantification of five anti-hypersensitivity drugs in saliva and urine by portable ion mobility spectrometry based on magnetic graphene oxide dispersive solid phase extraction. J Pharm Biomed Anal. 2020;189:113414.
Cui, Y., Liu, D., Zhao, M., Li, J., Yang, Y., Li, M., Gao, J., & Jiang, Y. (2020). A fast and simple approach for the quantification of five anti-hypersensitivity drugs in saliva and urine by portable ion mobility spectrometry based on magnetic graphene oxide dispersive solid phase extraction. Journal of Pharmaceutical and Biomedical Analysis, 189, 113414. https://doi.org/10.1016/j.jpba.2020.113414
Cui Y, et al. A Fast and Simple Approach for the Quantification of Five Anti-hypersensitivity Drugs in Saliva and Urine By Portable Ion Mobility Spectrometry Based On Magnetic Graphene Oxide Dispersive Solid Phase Extraction. J Pharm Biomed Anal. 2020 Jun 10;189:113414. PubMed PMID: 32629193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A fast and simple approach for the quantification of five anti-hypersensitivity drugs in saliva and urine by portable ion mobility spectrometry based on magnetic graphene oxide dispersive solid phase extraction. AU - Cui,Yixuan, AU - Liu,Di, AU - Zhao,Mengqiang, AU - Li,Junmei, AU - Yang,Yuke, AU - Li,Mengjiao, AU - Gao,Jinglin, AU - Jiang,Ye, Y1 - 2020/06/10/ PY - 2020/02/06/received PY - 2020/05/30/revised PY - 2020/06/03/accepted PY - 2020/7/7/pubmed PY - 2020/7/7/medline PY - 2020/7/7/entrez KW - Analysis KW - Anti-hypersensitivity drugs KW - Ion mobility spectrometry KW - Magnetic graphene oxide KW - Rapid in-situscreening KW - Saliva and urine SP - 113414 EP - 113414 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 189 N2 - Fatal road traffic crashes are often related to multifarious risk factors, among which driving under the influence of drugs (DUID) has been reported as a significantly contributing cause. The first worry about the side-effect of influencing driving drugs is central nervous system adverse reaction, and anti-hypersensitivity drugs are a class of drugs with such side effects meanwhile has been widely used for common allergic diseases thus posing a great challenge to road safety and demanding a rapid and efficient method to detect. In this work, a method based on magnetic graphene oxide dispersive solid phase extraction (MGO-D-SPE) combined with ion mobility spectrometry (IMS) was firstly introduced for simultaneous determination of ephedrine, pseudoephedrine, diphenhydramine, promethazine and terfenadine in saliva and urine matrices. The prepared MGO was characterized by Fourier transform infrared (FT-IR) spectroscopy and thermo gravimetric analysis (TGA). Various parameters affecting extraction efficiency as well as instrumental acquisition sensitivity were studied and optimized. Under the optimum experimental conditions, the method was fully validated and the results demonstrated that the proposed method exhibited some advantages, including a good linearity covering large concentration ranges of 51.0-3040 ng ml-1 for five anti-hypersensitivity drugs, and good accuracy was also obtained with high precision (CV% < 5.0 %). LODs and LOQs were 10.2-50.4 ng·mL-1 and 30.6-101.3 ng·mL-1, respectively. Consequently, the MGO-D-SPE-IMS methodology succeeded in building a hitherto unexplored tool for quantifying anti-hypersensitivity drugs in saliva and urine matrices of interest in DUID research field. SN - 1873-264X UR - https://www.unboundmedicine.com/medline/citation/32629193/A_fast_and_simple_approach_for_the_quantification_of_five_anti-hypersensitivity_drugs_in_saliva_and_urine_by_portable_ion_mobility_spectrometry_based_on_magnetic_graphene_oxide_dispersive_solid_phase_extraction L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(20)31300-5 DB - PRIME DP - Unbound Medicine ER -
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