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Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats.
Auton Neurosci. 2020 09; 227:102695.AN

Abstract

Damage to the insular cortex (IC) results in serious cardiovascular consequences and evidence indicates that the characteristics are lateralized. However, a study comparing the effects of focal experimental hemorrhage between IC sides was never performed. We compared the cardiovascular, autonomic and cardiac changes produced by focal experimental hemorrhage (ICH) into the left (L) or right (R) IC. Wistar rats were submitted to microinjection of autologous blood (ICH) or saline (n = 6 each side/group) into the R or L IC. Blood pressure (BP), heart rate (HR) and renal sympathetic activity (RSNA) were recorded. Measurements of calcium transient and sarcoplasmic Ca2+ ATPase expression in cardiomyocytes were performed. ICH increased baseline HR (Δ:L-ICH 452 ± 13 vs saline 407 ± 11 bpm; R-ICH 450 ± 7 vs saline 406 ± 8 bpm, P < 0.05) without changing BP. HR was restored to baseline levels after i.v. atenolol. Strikingly, ICH rats presented a reduced baseline RSNA (Δ:L-ICH 122 ± 4 vs saline 148 ± 11 spikes/s; R-ICH 112 ± 5 vs saline 148 ± 7 spikes/s, P < 0.05). After 24 h of ICH we observed a marked increase in cardiac ectopies and this number was greater after ICH R-IC. Heart weight, calcium amplitude and SERCA expression were reduced only in ICH R-IC. Focal stroke into IC can alter the cardiac and renal autonomic control. Damage to the R-IC produces a greater number of arrhythmias and changes in calcium dynamics in cardiac cells indicating that the cardiovascular consequences are hemisphere-dependent. These findings confirm asymmetry for cardiac autonomic control at the IC and help to understand the cardiac and renal implications observed after specific side cortical damage.

Authors+Show Affiliations

Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address: carlosxavier@ufg.br.Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: peliky@icb.ufmg.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32629215

Citation

Marins, Fernanda Ribeiro, et al. "Autonomic and Cardiovascular Consequences Resulting From Experimental Hemorrhagic Stroke in the Left or Right Intermediate Insular Cortex in Rats." Autonomic Neuroscience : Basic & Clinical, vol. 227, 2020, p. 102695.
Marins FR, Limborço-Filho M, D'Abreu BF, et al. Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats. Auton Neurosci. 2020;227:102695.
Marins, F. R., Limborço-Filho, M., D'Abreu, B. F., Machado de Almeida, P. W., Gavioli, M., Xavier, C. H., Oppenheimer, S. M., Guatimosim, S., & Fontes, M. A. P. (2020). Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats. Autonomic Neuroscience : Basic & Clinical, 227, 102695. https://doi.org/10.1016/j.autneu.2020.102695
Marins FR, et al. Autonomic and Cardiovascular Consequences Resulting From Experimental Hemorrhagic Stroke in the Left or Right Intermediate Insular Cortex in Rats. Auton Neurosci. 2020;227:102695. PubMed PMID: 32629215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats. AU - Marins,Fernanda Ribeiro, AU - Limborço-Filho,Marcelo, AU - D'Abreu,Bárbara Flecha, AU - Machado de Almeida,Pedro W, AU - Gavioli,Mariana, AU - Xavier,Carlos Henrique, AU - Oppenheimer,Stephen M, AU - Guatimosim,Silvia, AU - Fontes,Marco Antônio Peliky, Y1 - 2020/06/24/ PY - 2020/04/14/received PY - 2020/06/20/revised PY - 2020/06/21/accepted PY - 2020/7/7/pubmed PY - 2020/7/7/medline PY - 2020/7/7/entrez KW - Asymmetry KW - Autonomic KW - Cardiovascular KW - Insula KW - Rats KW - Stroke SP - 102695 EP - 102695 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 227 N2 - Damage to the insular cortex (IC) results in serious cardiovascular consequences and evidence indicates that the characteristics are lateralized. However, a study comparing the effects of focal experimental hemorrhage between IC sides was never performed. We compared the cardiovascular, autonomic and cardiac changes produced by focal experimental hemorrhage (ICH) into the left (L) or right (R) IC. Wistar rats were submitted to microinjection of autologous blood (ICH) or saline (n = 6 each side/group) into the R or L IC. Blood pressure (BP), heart rate (HR) and renal sympathetic activity (RSNA) were recorded. Measurements of calcium transient and sarcoplasmic Ca2+ ATPase expression in cardiomyocytes were performed. ICH increased baseline HR (Δ:L-ICH 452 ± 13 vs saline 407 ± 11 bpm; R-ICH 450 ± 7 vs saline 406 ± 8 bpm, P < 0.05) without changing BP. HR was restored to baseline levels after i.v. atenolol. Strikingly, ICH rats presented a reduced baseline RSNA (Δ:L-ICH 122 ± 4 vs saline 148 ± 11 spikes/s; R-ICH 112 ± 5 vs saline 148 ± 7 spikes/s, P < 0.05). After 24 h of ICH we observed a marked increase in cardiac ectopies and this number was greater after ICH R-IC. Heart weight, calcium amplitude and SERCA expression were reduced only in ICH R-IC. Focal stroke into IC can alter the cardiac and renal autonomic control. Damage to the R-IC produces a greater number of arrhythmias and changes in calcium dynamics in cardiac cells indicating that the cardiovascular consequences are hemisphere-dependent. These findings confirm asymmetry for cardiac autonomic control at the IC and help to understand the cardiac and renal implications observed after specific side cortical damage. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/32629215/Autonomic_and_cardiovascular_consequences_resulting_from_experimental_hemorrhagic_stroke_in_the_left_or_right_intermediate_insular_cortex_in_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(20)30129-6 DB - PRIME DP - Unbound Medicine ER -