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Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation.
Psychiatry Res. 2020 09; 291:113271.PR

Abstract

Previous studies have reported associations between the serotonin transporter 5-HTTLPR genotype and antisocial and aggressive traits and between child maltreatment and antisocial traits. However, few studies have examined whether 5-HTTLPR moderates the influence of childhood maltreatment on callous and unemotional traits, a hallmark of psychopathy. Using a prospective cohort design, children with documented cases of maltreatment and matched controls were followed up and interviewed in adulthood. DNA was extracted from blood and saliva (N = 414) and callous-unemotional (CU) traits were assessed. Childhood maltreatment predicted higher CU scores in adulthood, whereas the effect of 5-HTTLPR was not significant. The effect of child maltreatment on CU traits did not differ by genetic risk (high or low activity 5-HTTLPR), whereas controls with the LL genotype had higher CU scores than controls with the SS genotype. Similar results were found for females and White, non-Hispanics, but not for males and Blacks. Variations in 5-HTTLPR did not affect the impact of child maltreatment on CU traits in adulthood. Genetic risk had a stronger effect on adults with lower environmental risk (controls). Having a history of child maltreatment or the LL genotype placed participants at risk for higher levels of callous and unemotional trait scores.

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Authors+Show Affiliations

Widom CS
Psychology Department, John Jay College and Graduate Center, City University of New York, 524W. 59th Street, New York, NY 10019, USA. Electronic address: cwidom@jjay.cuny.edu.
Miller D
Psychology Department, John Jay College, City University of New York, 524W. 59th Street, New York, NY 10019, USA.
Li X
Psychology Department, John Jay College, City University of New York, 524W. 59th Street, New York, NY 10019, USA.
Gordon D
Department of Genetics and Human Genetics Institute, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ, 08854-8082, USA.
Brzustowicz L
Department of Genetics and Human Genetics Institute, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ, 08854-8082, USA.

MeSH

AdultAggressionChildChild AbuseChild, PreschoolConduct DisorderFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsSerotonin Plasma Membrane Transport Proteins

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

32629297

Citation

Widom, Cathy Spatz, et al. "Childhood Maltreatment, Serotonin Transporter Gene, and Risk for Callous and Unemotional Traits: a Prospective Investigation." Psychiatry Research, vol. 291, 2020, p. 113271.
Widom CS, Miller D, Li X, et al. Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation. Psychiatry Res. 2020;291:113271.
Widom, C. S., Miller, D., Li, X., Gordon, D., & Brzustowicz, L. (2020). Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation. Psychiatry Research, 291, 113271. https://doi.org/10.1016/j.psychres.2020.113271
Widom CS, et al. Childhood Maltreatment, Serotonin Transporter Gene, and Risk for Callous and Unemotional Traits: a Prospective Investigation. Psychiatry Res. 2020;291:113271. PubMed PMID: 32629297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation. AU - Widom,Cathy Spatz, AU - Miller,Dana, AU - Li,Xuechen, AU - Gordon,Derek, AU - Brzustowicz,Linda, Y1 - 2020/07/02/ PY - 2020/01/16/received PY - 2020/06/23/revised PY - 2020/07/01/accepted PY - 2020/7/7/pubmed PY - 2020/12/29/medline PY - 2020/7/7/entrez KW - 5-HTTLPR KW - Abuse/neglect KW - Callous/unemotional traits KW - Child maltreatment KW - Prospective cohort design KW - Serotonin SP - 113271 EP - 113271 JF - Psychiatry research JO - Psychiatry Res VL - 291 N2 - Previous studies have reported associations between the serotonin transporter 5-HTTLPR genotype and antisocial and aggressive traits and between child maltreatment and antisocial traits. However, few studies have examined whether 5-HTTLPR moderates the influence of childhood maltreatment on callous and unemotional traits, a hallmark of psychopathy. Using a prospective cohort design, children with documented cases of maltreatment and matched controls were followed up and interviewed in adulthood. DNA was extracted from blood and saliva (N = 414) and callous-unemotional (CU) traits were assessed. Childhood maltreatment predicted higher CU scores in adulthood, whereas the effect of 5-HTTLPR was not significant. The effect of child maltreatment on CU traits did not differ by genetic risk (high or low activity 5-HTTLPR), whereas controls with the LL genotype had higher CU scores than controls with the SS genotype. Similar results were found for females and White, non-Hispanics, but not for males and Blacks. Variations in 5-HTTLPR did not affect the impact of child maltreatment on CU traits in adulthood. Genetic risk had a stronger effect on adults with lower environmental risk (controls). Having a history of child maltreatment or the LL genotype placed participants at risk for higher levels of callous and unemotional trait scores. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/32629297/Childhood_maltreatment_serotonin_transporter_gene_and_risk_for_callous_and_unemotional_traits:_A_prospective_investigation_ DB - PRIME DP - Unbound Medicine ER -