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Nutritional deficiency and placenta calcification underlie constitutive, selective embryo loss in pregnant South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha).
Theriogenology. 2020 Jun 07; 155:77-87.T

Abstract

Plains vizcacha females are able to ovulate up to 800 oocytes per estrus cycle. However, just 10-12 embryos are implanted and only two of them, those located nearest the cervix, are gestated to term. Between 26 and 70 days post-coitum, a constitutive resorption occurs from the embryos located proximal to the ovary, extending progressively toward those distally implanted. Our previous studies on the dynamics of gestation in L. maximus, led us to hypothesize some kind of placental and nutritional insufficiency as the basis for the resorption process. We analyzed histology and arterial architecture of the reproductive tract in pregnant and non-pregnant females. Uterine horns are irrigated through the uterine artery, a branch of the internal iliac artery, in an ascending way from the cervix; segmental arteries irrigating the embryo vesicles become thinner as they approach the ovary. Contrast solution administered during angiographies accumulated in the placenta of embryos closest to cervix. Thus, blood stream favors the embryos nearest the cervix, indicating a gradual nutritional deficiency of those closest to the ovary. Besides, placenta becomes calcified early, at mid-gestation, during the resorption process. Finally, the detection of specialized endothelial venules and inflammatory cells suggest the concurrent participation of immunological processes in embryo vesicles undergoing resorption.

Authors+Show Affiliations

Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.Cátedra de Histología y Embriología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Buenos Aires, Argentina.Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.Centro de Ciencias Veterinarias (CCV), Universidad Maimónides, Buenos Aires, Argentina.Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.Centro de Ciencias Veterinarias (CCV), Universidad Maimónides, Buenos Aires, Argentina.Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address: vitullo.alfredo@maimonides.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32629338

Citation

Giacchino, Mariela, et al. "Nutritional Deficiency and Placenta Calcification Underlie Constitutive, Selective Embryo Loss in Pregnant South American Plains Vizcacha, Lagostomus Maximus (Rodentia, Caviomorpha)." Theriogenology, vol. 155, 2020, pp. 77-87.
Giacchino M, Claver JA, Inserra PI, et al. Nutritional deficiency and placenta calcification underlie constitutive, selective embryo loss in pregnant South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha). Theriogenology. 2020;155:77-87.
Giacchino, M., Claver, J. A., Inserra, P. I., Lange, F. D., Gariboldi, M. C., Ferraris, S. R., & Vitullo, A. D. (2020). Nutritional deficiency and placenta calcification underlie constitutive, selective embryo loss in pregnant South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha). Theriogenology, 155, 77-87. https://doi.org/10.1016/j.theriogenology.2020.06.003
Giacchino M, et al. Nutritional Deficiency and Placenta Calcification Underlie Constitutive, Selective Embryo Loss in Pregnant South American Plains Vizcacha, Lagostomus Maximus (Rodentia, Caviomorpha). Theriogenology. 2020 Jun 7;155:77-87. PubMed PMID: 32629338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional deficiency and placenta calcification underlie constitutive, selective embryo loss in pregnant South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha). AU - Giacchino,Mariela, AU - Claver,Juan A, AU - Inserra,Pablo If, AU - Lange,Fernando D, AU - Gariboldi,María C, AU - Ferraris,Sergio R, AU - Vitullo,Alfredo D, Y1 - 2020/06/07/ PY - 2019/12/11/received PY - 2020/05/25/revised PY - 2020/06/04/accepted PY - 2020/7/7/pubmed PY - 2020/7/7/medline PY - 2020/7/7/entrez KW - Embryo resorption KW - Nutritional deficiency KW - Placenta calcification KW - Pseudoseptum KW - Uterine circulation KW - Vizcacha SP - 77 EP - 87 JF - Theriogenology JO - Theriogenology VL - 155 N2 - Plains vizcacha females are able to ovulate up to 800 oocytes per estrus cycle. However, just 10-12 embryos are implanted and only two of them, those located nearest the cervix, are gestated to term. Between 26 and 70 days post-coitum, a constitutive resorption occurs from the embryos located proximal to the ovary, extending progressively toward those distally implanted. Our previous studies on the dynamics of gestation in L. maximus, led us to hypothesize some kind of placental and nutritional insufficiency as the basis for the resorption process. We analyzed histology and arterial architecture of the reproductive tract in pregnant and non-pregnant females. Uterine horns are irrigated through the uterine artery, a branch of the internal iliac artery, in an ascending way from the cervix; segmental arteries irrigating the embryo vesicles become thinner as they approach the ovary. Contrast solution administered during angiographies accumulated in the placenta of embryos closest to cervix. Thus, blood stream favors the embryos nearest the cervix, indicating a gradual nutritional deficiency of those closest to the ovary. Besides, placenta becomes calcified early, at mid-gestation, during the resorption process. Finally, the detection of specialized endothelial venules and inflammatory cells suggest the concurrent participation of immunological processes in embryo vesicles undergoing resorption. SN - 1879-3231 UR - https://www.unboundmedicine.com/medline/citation/32629338/Nutritional_deficiency_and_placenta_calcification_underlie_constitutive,_selective_embryo_loss_in_pregnant_South_American_plains_vizcacha,_Lagostomus_maximus_(Rodentia,_Caviomorpha) L2 - https://linkinghub.elsevier.com/retrieve/pii/S0093-691X(20)30353-8 DB - PRIME DP - Unbound Medicine ER -
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