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Inflammatory Cell Infiltration of Adrenals in COVID-19.
Horm Metab Res. 2020 Sep; 52(9):639-641.HM

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zinserling VA
S. P. Botkin Clinical Infectious Diseases Hospital, St. Petersburg, Russia. V. A. Almasov Scientific Research Center, St. Petersburg, Russia.
Semenova NY
S. P. Botkin Clinical Infectious Diseases Hospital, St. Petersburg, Russia. V. A. Almasov Scientific Research Center, St. Petersburg, Russia.
Markov AG
Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia.
Rybalchenko OV
Faculty of Medicine, Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia.
Wang J
Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Rodionov RN
Division of Angiology, Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia.
Bornstein SR
Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Department of Diabetes, School of Life Course Science and Medicine, King´s College London, London, UK. Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Zurich, Switzerland.

MeSH

Adrenal GlandsBetacoronavirusCOVID-19Coronavirus InfectionsHumansPandemicsPneumonia, ViralSARS-CoV-2T-Lymphocytes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32629518

Citation

Zinserling, Vsevolod A., et al. "Inflammatory Cell Infiltration of Adrenals in COVID-19." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 52, no. 9, 2020, pp. 639-641.
Zinserling VA, Semenova NY, Markov AG, et al. Inflammatory Cell Infiltration of Adrenals in COVID-19. Horm Metab Res. 2020;52(9):639-641.
Zinserling, V. A., Semenova, N. Y., Markov, A. G., Rybalchenko, O. V., Wang, J., Rodionov, R. N., & Bornstein, S. R. (2020). Inflammatory Cell Infiltration of Adrenals in COVID-19. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 52(9), 639-641. https://doi.org/10.1055/a-1191-8094
Zinserling VA, et al. Inflammatory Cell Infiltration of Adrenals in COVID-19. Horm Metab Res. 2020;52(9):639-641. PubMed PMID: 32629518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory Cell Infiltration of Adrenals in COVID-19. AU - Zinserling,Vsevolod A, AU - Semenova,Natalya Yu, AU - Markov,Alexander G, AU - Rybalchenko,Oksana V, AU - Wang,Jun, AU - Rodionov,Roman N, AU - Bornstein,Stefan R, Y1 - 2020/07/06/ PY - 2020/7/7/pubmed PY - 2020/9/18/medline PY - 2020/7/7/entrez SP - 639 EP - 641 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 52 IS - 9 N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/32629518/Inflammatory_Cell_Infiltration_of_Adrenals_in_COVID_19_ DB - PRIME DP - Unbound Medicine ER -