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Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study.
Brain Sci. 2020 Jun 30; 10(7)BS

Abstract

Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.

Authors+Show Affiliations

Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland.Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland.Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland.Department of Adult Psychiatry, Poznan University of Medical Sciences, 60-572 Poznań, Poland.Department of Adult Psychiatry, Poznan University of Medical Sciences, 60-572 Poznań, Poland. Department of Psychiatric Nursing, Poznan University of Medical Sciences, 60-179 Poznań, Poland.Department of Bioengineering, Faculty of Environmental Management and Agriculture, West Pomeranian University of Technology, 71-434 Szczecin, Poland.Chair and Department of Physiology, 70-111 Szczecin, Poland.Department of Genetics, Wroclaw Medical University, 50-368 Wrocław, Poland.Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA. Department of Regenerative Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32629800

Citation

Reginia, Artur, et al. "Markers of Regenerative Processes in Patients With Bipolar Disorder: a Case-control Study." Brain Sciences, vol. 10, no. 7, 2020.
Reginia A, Samochowiec J, Jabłoński M, et al. Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study. Brain Sci. 2020;10(7).
Reginia, A., Samochowiec, J., Jabłoński, M., Ferensztajn-Rochowiak, E., Rybakowski, J. K., Telesiński, A., Tarnowski, M., Misiak, B., Ratajczak, M. Z., & Kucharska-Mazur, J. (2020). Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study. Brain Sciences, 10(7). https://doi.org/10.3390/brainsci10070408
Reginia A, et al. Markers of Regenerative Processes in Patients With Bipolar Disorder: a Case-control Study. Brain Sci. 2020 Jun 30;10(7) PubMed PMID: 32629800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study. AU - Reginia,Artur, AU - Samochowiec,Jerzy, AU - Jabłoński,Marcin, AU - Ferensztajn-Rochowiak,Ewa, AU - Rybakowski,Janusz K, AU - Telesiński,Arkadiusz, AU - Tarnowski,Maciej, AU - Misiak,Błażej, AU - Ratajczak,Mariusz Z, AU - Kucharska-Mazur,Jolanta, Y1 - 2020/06/30/ PY - 2020/05/27/received PY - 2020/06/27/revised PY - 2020/06/28/accepted PY - 2020/7/8/entrez KW - VSEL KW - bipolar disorder KW - stem cells JF - Brain sciences JO - Brain Sci VL - 10 IS - 7 N2 - Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder. SN - 2076-3425 UR - https://www.unboundmedicine.com/medline/citation/32629800/Markers_of_Regenerative_Processes_in_Patients_with_Bipolar_Disorder:_A_Case-control_Study DB - PRIME DP - Unbound Medicine ER -