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Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets.
Pharmaceutics. 2020 Jun 30; 12(7)P

Abstract

Fenofibrate-loaded electrospun microfibrous sheets were prepared in an attempt to enhance the dissolution of the poorly soluble antihyperlipidemic agent and to improve its bioavailability. Physicochemical changes that appeared during the electrospinning process were monitored using a wide array of solid-state characterization techniques, including attenuated total reflectance Fourier-transformed infrared spectroscopy and positron annihilation lifetime spectroscopy, while fiber morphology was monitored via scanning electron microscopy. Dissolution studies carried out both in 0.025 M sodium dodecyl sulfate and in water revealed an immediate release of the active agent, with an approximately 40-fold release rate enhancement in water when compared to the micronized active agent. The dramatic increase in dissolution was attributed partially to the amorphous form of the originally crystalline active agent and the rapid disintegration of the electrospun microfibrous sheet due to its high surface area and porosity. The obtained results could pave the way for a formulation of the frequently used antihyperlipidemic agent with increased bioavailability.

Authors+Show Affiliations

Department of Drugs Industry and Pharmaceutical Management, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gh. Marinescu 38, 540139 Targu Mures, Romania.Department of Drugs Industry and Pharmaceutical Management, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gh. Marinescu 38, 540139 Targu Mures, Romania.University Pharmacy Department of Pharmacy Administration, Semmelweis University, H-1092 Hőgyes Endre utca 7-9, 1085 Budapest, Hungary.Department of Mechanical Engineering, Faculty of Technical and Human Sciences, Sapientia Hungarian University of Transylvania, Corunca, 1C, 540485 Targu Mures, Romania.Department of Mechanical Engineering, Faculty of Technical and Human Sciences, Sapientia Hungarian University of Transylvania, Corunca, 1C, 540485 Targu Mures, Romania.Department of Drugs Industry and Pharmaceutical Management, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gh. Marinescu 38, 540139 Targu Mures, Romania.University Pharmacy Department of Pharmacy Administration, Semmelweis University, H-1092 Hőgyes Endre utca 7-9, 1085 Budapest, Hungary.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32629988

Citation

Sipos, Emese, et al. "Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets." Pharmaceutics, vol. 12, no. 7, 2020.
Sipos E, Csatári T, Kazsoki A, et al. Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets. Pharmaceutics. 2020;12(7).
Sipos, E., Csatári, T., Kazsoki, A., Gergely, A., Bitay, E., Szabó, Z. I., & Zelkó, R. (2020). Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets. Pharmaceutics, 12(7). https://doi.org/10.3390/pharmaceutics12070612
Sipos E, et al. Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets. Pharmaceutics. 2020 Jun 30;12(7) PubMed PMID: 32629988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets. AU - Sipos,Emese, AU - Csatári,Tamás, AU - Kazsoki,Adrienn, AU - Gergely,Attila, AU - Bitay,Enikő, AU - Szabó,Zoltán-István, AU - Zelkó,Romána, Y1 - 2020/06/30/ PY - 2020/06/08/received PY - 2020/06/26/revised PY - 2020/06/29/accepted PY - 2020/7/8/entrez KW - Positron Annihilation Lifetime Spectroscopy (PALS) KW - amorphization KW - dissolution enhancement KW - electrospinning KW - microfibers JF - Pharmaceutics JO - Pharmaceutics VL - 12 IS - 7 N2 - Fenofibrate-loaded electrospun microfibrous sheets were prepared in an attempt to enhance the dissolution of the poorly soluble antihyperlipidemic agent and to improve its bioavailability. Physicochemical changes that appeared during the electrospinning process were monitored using a wide array of solid-state characterization techniques, including attenuated total reflectance Fourier-transformed infrared spectroscopy and positron annihilation lifetime spectroscopy, while fiber morphology was monitored via scanning electron microscopy. Dissolution studies carried out both in 0.025 M sodium dodecyl sulfate and in water revealed an immediate release of the active agent, with an approximately 40-fold release rate enhancement in water when compared to the micronized active agent. The dramatic increase in dissolution was attributed partially to the amorphous form of the originally crystalline active agent and the rapid disintegration of the electrospun microfibrous sheet due to its high surface area and porosity. The obtained results could pave the way for a formulation of the frequently used antihyperlipidemic agent with increased bioavailability. SN - 1999-4923 UR - https://www.unboundmedicine.com/medline/citation/32629988/Preparation_and_Characterization_of_Fenofibrate-Loaded_PVP_Electrospun_Microfibrous_Sheets DB - PRIME DP - Unbound Medicine ER -
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