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Caenorhabditis elegans Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly.
Development. 2020 Jul 31; 147(14)D

Abstract

Self-avoidance is a conserved mechanism that prevents crossover between sister dendrites from the same neuron, ensuring proper functioning of the neuronal circuits. Several adhesion molecules are known to be important for dendrite self-avoidance, but the underlying molecular mechanisms are incompletely defined. Here, we show that FMI-1/Flamingo, an atypical cadherin, is required autonomously for self-avoidance in the multidendritic PVD neuron of Caenorhabditis elegans The fmi-1 mutant shows increased crossover between sister PVD dendrites. Our genetic analysis suggests that FMI-1 promotes transient F-actin assembly at the tips of contacting sister dendrites to facilitate their efficient retraction during self-avoidance events, probably by interacting with WSP-1/N-WASP. Mutations of vang-1, which encodes the planar cell polarity protein Vangl2 previously shown to inhibit F-actin assembly, suppress self-avoidance defects of the fmi-1 mutant. FMI-1 downregulates VANG-1 levels probably through forming protein complexes. Our study identifies molecular links between Flamingo and the F-actin cytoskeleton that facilitate efficient dendrite self-avoidance.

Authors+Show Affiliations

Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan chunliangpan@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32631831

Citation

Hsu, Hao-Wei, et al. "Caenorhabditis Elegans Flamingo FMI-1 Controls Dendrite Self-avoidance Through F-actin Assembly." Development (Cambridge, England), vol. 147, no. 14, 2020.
Hsu HW, Liao CP, Chiang YC, et al. Caenorhabditis elegans Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly. Development. 2020;147(14).
Hsu, H. W., Liao, C. P., Chiang, Y. C., Syu, R. T., & Pan, C. L. (2020). Caenorhabditis elegans Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly. Development (Cambridge, England), 147(14). https://doi.org/10.1242/dev.179168
Hsu HW, et al. Caenorhabditis Elegans Flamingo FMI-1 Controls Dendrite Self-avoidance Through F-actin Assembly. Development. 2020 Jul 31;147(14) PubMed PMID: 32631831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caenorhabditis elegans Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly. AU - Hsu,Hao-Wei, AU - Liao,Chien-Po, AU - Chiang,Yueh-Chen, AU - Syu,Ru-Ting, AU - Pan,Chun-Liang, Y1 - 2020/07/31/ PY - 2019/04/08/received PY - 2020/06/29/accepted PY - 2020/7/8/pubmed PY - 2020/7/8/medline PY - 2020/7/8/entrez KW - Actin KW - C. elegans KW - Dendrite KW - Flamingo KW - Planar polarity KW - Self-avoidance JF - Development (Cambridge, England) JO - Development VL - 147 IS - 14 N2 - Self-avoidance is a conserved mechanism that prevents crossover between sister dendrites from the same neuron, ensuring proper functioning of the neuronal circuits. Several adhesion molecules are known to be important for dendrite self-avoidance, but the underlying molecular mechanisms are incompletely defined. Here, we show that FMI-1/Flamingo, an atypical cadherin, is required autonomously for self-avoidance in the multidendritic PVD neuron of Caenorhabditis elegans The fmi-1 mutant shows increased crossover between sister PVD dendrites. Our genetic analysis suggests that FMI-1 promotes transient F-actin assembly at the tips of contacting sister dendrites to facilitate their efficient retraction during self-avoidance events, probably by interacting with WSP-1/N-WASP. Mutations of vang-1, which encodes the planar cell polarity protein Vangl2 previously shown to inhibit F-actin assembly, suppress self-avoidance defects of the fmi-1 mutant. FMI-1 downregulates VANG-1 levels probably through forming protein complexes. Our study identifies molecular links between Flamingo and the F-actin cytoskeleton that facilitate efficient dendrite self-avoidance. SN - 1477-9129 UR - https://www.unboundmedicine.com/medline/citation/32631831/C._elegans_flamingo_FMI-1_controls_dendrite_self-avoidance_through_F-actin_assembly L2 - http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=32631831 DB - PRIME DP - Unbound Medicine ER -
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