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Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett's esophagus.
J Zhejiang Univ Sci B. 2020 Jul; 21(7):581-589.JZ

Abstract

OBJECTIVE

To determine the characteristics of postprandial proximal gastric acid pockets (PPGAPs) and their association with gastroesophageal acid reflux in patients with Barrett's esophagus (BE).

METHODS

Fifteen patients with BE (defined by columnar lined esophagus of ≥1 cm) and 15 healthy individuals that were matched for age, gender, and body mass index, were recruited. The fasting intragastric pH and the appearance time, length, lowest pH, and mean pH of the PPGAP were determined using a single pH electrode pull-through experiment. For BE patients, a gastroesophageal reflux disease questionnaire (GerdQ) was completed and esophageal 24-h pH monitoring was carried out.

RESULTS

The PPGAP was significantly longer (5 (3, 5) cm vs. 2 (1, 2) cm) and the lowest pH (1.1 (0.8, 1.5) vs. 1.6 (1.4, 1.9)) was significantly lower in patients with short-segment BE than in healthy individuals. The PPGAP started to appear proximally from the gastroesophageal pH step-up point to the esophageal lumen. The acidity of the PPGAP was higher in the distal segment than in the proximal segment. In short-segment BE patients, there were significant correlations between the acidity and the appearance time and length of the PPGAP. The length and acidity of the PPGAP were positively associated with gastroesophageal acid reflux episodes. The acidity of the PPGAP was associated with the DeMeester scores, the GerdQ scores, and the fasting intragastric pH.

CONCLUSIONS

In patients with short-segment BE, a PPGAP is commonly seen. Its length and acidity of PPGAP are associated with gastroesophageal acid reflux, the DeMeester score, and the GerdQ score in patients with short-segment BE.

Authors+Show Affiliations

Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Baotou 014040, China.Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Baotou 014040, China.Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710049, China.Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710049, China.Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710049, China.Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Baotou 014040, China.Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710049, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32633112

Citation

Nian, Yuan-Yuan, et al. "Postprandial Proximal Gastric Acid Pocket and Its Association With Gastroesophageal Acid Reflux in Patients With Short-segment Barrett's Esophagus." Journal of Zhejiang University. Science. B, vol. 21, no. 7, 2020, pp. 581-589.
Nian YY, Meng XM, Wu J, et al. Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett's esophagus. J Zhejiang Univ Sci B. 2020;21(7):581-589.
Nian, Y. Y., Meng, X. M., Wu, J., Jing, F. C., Wang, X. Q., Dang, T., & Zhang, J. (2020). Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett's esophagus. Journal of Zhejiang University. Science. B, 21(7), 581-589. https://doi.org/10.1631/jzus.B1900498
Nian YY, et al. Postprandial Proximal Gastric Acid Pocket and Its Association With Gastroesophageal Acid Reflux in Patients With Short-segment Barrett's Esophagus. J Zhejiang Univ Sci B. 2020;21(7):581-589. PubMed PMID: 32633112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett's esophagus. AU - Nian,Yuan-Yuan, AU - Meng,Xian-Mei, AU - Wu,Jing, AU - Jing,Fu-Chu, AU - Wang,Xue-Qin, AU - Dang,Tong, AU - Zhang,Jun, PY - 2020/7/8/entrez KW - Short-segment Barrett’s esophagus; Postprandial proximal gastric acid pocket (PPGAP); Gastroesophageal acid reflux SP - 581 EP - 589 JF - Journal of Zhejiang University. Science. B JO - J Zhejiang Univ Sci B VL - 21 IS - 7 N2 - OBJECTIVE: To determine the characteristics of postprandial proximal gastric acid pockets (PPGAPs) and their association with gastroesophageal acid reflux in patients with Barrett's esophagus (BE). METHODS: Fifteen patients with BE (defined by columnar lined esophagus of ≥1 cm) and 15 healthy individuals that were matched for age, gender, and body mass index, were recruited. The fasting intragastric pH and the appearance time, length, lowest pH, and mean pH of the PPGAP were determined using a single pH electrode pull-through experiment. For BE patients, a gastroesophageal reflux disease questionnaire (GerdQ) was completed and esophageal 24-h pH monitoring was carried out. RESULTS: The PPGAP was significantly longer (5 (3, 5) cm vs. 2 (1, 2) cm) and the lowest pH (1.1 (0.8, 1.5) vs. 1.6 (1.4, 1.9)) was significantly lower in patients with short-segment BE than in healthy individuals. The PPGAP started to appear proximally from the gastroesophageal pH step-up point to the esophageal lumen. The acidity of the PPGAP was higher in the distal segment than in the proximal segment. In short-segment BE patients, there were significant correlations between the acidity and the appearance time and length of the PPGAP. The length and acidity of the PPGAP were positively associated with gastroesophageal acid reflux episodes. The acidity of the PPGAP was associated with the DeMeester scores, the GerdQ scores, and the fasting intragastric pH. CONCLUSIONS: In patients with short-segment BE, a PPGAP is commonly seen. Its length and acidity of PPGAP are associated with gastroesophageal acid reflux, the DeMeester score, and the GerdQ score in patients with short-segment BE. SN - 1862-1783 UR - https://www.unboundmedicine.com/medline/citation/32633112/Postprandial_proximal_gastric_acid_pocket_and_its_association_with_gastroesophageal_acid_reflux_in_patients_with_short-segment_Barrett's_esophagus L2 - http://www.jzus.zju.edu.cn/article.php?doi=10.1631/jzus.B1900498 DB - PRIME DP - Unbound Medicine ER -
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