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Identification of hub genes involved in apparent metabolizable energy of chickens.
Anim Biotechnol. 2020 Jul 07 [Online ahead of print]AB

Abstract

Feed efficiency is one of the most economically significant traits in a breeding program. Apparent metabolizable energy is the most used method to evaluate energy utilization for feed efficiency. The purpose of this study was to identify candidate genes of chickens with divergent apparent metabolizable energy by bioinformatics analysis. The gene expression profile of duodenal of the highest and lowest apparent metabolizable energy-ranked birds were analyzed. Differentially expressed genes were picked out using GEO2R tool. Gene ontology and pathway analysis were performed using bioinformatics tools. Cytoscape software was used to visualize protein-protein network. There were 201 DEGs, including 99 up-regulated genes enriched in metabolic pathways, Cellular senescence and Focal adhesion, and 102 down-regulated genes enriched in metabolic pathways, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction, Calcium signaling pathway and Focal adhesion. Two important modules were detected and pathway enrichment analysis showed that they were mainly associated with Focal adhesion, Regulation of actin cytoskeleton and RNA transport. Fifteen hub genes were selected and among them, ITGA8, CDC42 and GSK3B might be the core genes related to apparent metabolizable energy of chickens. These hub genes can be used as biomarkers for apparent metabolizable energy and feed efficiency in breeding program of chickens.

Authors+Show Affiliations

Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Iran.Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Iran.Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32634039

Citation

Pezeshkian, Zahra, et al. "Identification of Hub Genes Involved in Apparent Metabolizable Energy of Chickens." Animal Biotechnology, 2020, pp. 1-8.
Pezeshkian Z, Mirhoseini SZ, Ghovvati S. Identification of hub genes involved in apparent metabolizable energy of chickens. Anim Biotechnol. 2020.
Pezeshkian, Z., Mirhoseini, S. Z., & Ghovvati, S. (2020). Identification of hub genes involved in apparent metabolizable energy of chickens. Animal Biotechnology, 1-8. https://doi.org/10.1080/10495398.2020.1784187
Pezeshkian Z, Mirhoseini SZ, Ghovvati S. Identification of Hub Genes Involved in Apparent Metabolizable Energy of Chickens. Anim Biotechnol. 2020 Jul 7;1-8. PubMed PMID: 32634039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of hub genes involved in apparent metabolizable energy of chickens. AU - Pezeshkian,Zahra, AU - Mirhoseini,Seyed Ziaeddin, AU - Ghovvati,Shahrokh, Y1 - 2020/07/07/ PY - 2020/7/8/entrez PY - 2020/7/8/pubmed PY - 2020/7/8/medline KW - Feed efficiency KW - apparent metabolizable energy KW - bioinformatics analysis KW - chicken KW - protein–protein interaction SP - 1 EP - 8 JF - Animal biotechnology JO - Anim. Biotechnol. N2 - Feed efficiency is one of the most economically significant traits in a breeding program. Apparent metabolizable energy is the most used method to evaluate energy utilization for feed efficiency. The purpose of this study was to identify candidate genes of chickens with divergent apparent metabolizable energy by bioinformatics analysis. The gene expression profile of duodenal of the highest and lowest apparent metabolizable energy-ranked birds were analyzed. Differentially expressed genes were picked out using GEO2R tool. Gene ontology and pathway analysis were performed using bioinformatics tools. Cytoscape software was used to visualize protein-protein network. There were 201 DEGs, including 99 up-regulated genes enriched in metabolic pathways, Cellular senescence and Focal adhesion, and 102 down-regulated genes enriched in metabolic pathways, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction, Calcium signaling pathway and Focal adhesion. Two important modules were detected and pathway enrichment analysis showed that they were mainly associated with Focal adhesion, Regulation of actin cytoskeleton and RNA transport. Fifteen hub genes were selected and among them, ITGA8, CDC42 and GSK3B might be the core genes related to apparent metabolizable energy of chickens. These hub genes can be used as biomarkers for apparent metabolizable energy and feed efficiency in breeding program of chickens. SN - 1532-2378 UR - https://www.unboundmedicine.com/medline/citation/32634039/Identification_of_hub_genes_involved_in_apparent_metabolizable_energy_of_chickens L2 - http://www.tandfonline.com/doi/full/10.1080/10495398.2020.1784187 DB - PRIME DP - Unbound Medicine ER -
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