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Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease.
Nutrients. 2020 Jul 03; 12(7)N

Abstract

The prevention or alleviation of neurodegenerative diseases, including Alzheimer's disease (AD), is a challenge for contemporary health services. The aim of this study was to review the literature on the prevention or alleviation of AD by introducing an appropriate carnitine-rich diet, dietary carnitine supplements and the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, which contains elements of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. L-carnitine (LC) plays a crucial role in the energetic metabolism of the cell. A properly balanced diet contains a substantial amount of LC as well as essential amino acids and microelements taking part in endogenous carnitine synthesis. In healthy people, carnitine biosynthesis is sufficient to prevent the symptoms of carnitine deficiency. In persons with dysfunction of mitochondria, e.g., with AD connected with extensive degeneration of the brain structures, there are often serious disturbances in the functioning of the whole organism. The Mediterranean diet is characterized by a high consumption of fruits and vegetables, cereals, nuts, olive oil, and seeds as the major source of fats, moderate consumption of fish and poultry, low to moderate consumption of dairy products and alcohol, and low intake of red and processed meat. The introduction of foodstuffs rich in carnitine and the MIND diet or carnitine supplementation of the AD patients may improve their functioning in everyday life.

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Authors+Show Affiliations

Kepka A
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Ochocinska A
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Borzym-Kluczyk M
Department of Pharmaceutical Biochemistry, Medical University of Bialystok, 15-089 Bialystok, Poland.
Skorupa E
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Stasiewicz-Jarocka B
Department of Medical Genetics, Medical University of Bialystok, 15-089 Bialystok, Poland.
Chojnowska S
Faculty of Health Sciences, Lomza State University of Applied Sciences, 18-400 Lomza, Poland.
Waszkiewicz N
Department of Psychiatry, Medical University of Bialystok, 15-089 Bialystok, Poland.

MeSH

AgedAged, 80 and overAlzheimer DiseaseCarnitineDiet, HealthyDiet, MediterraneanDietary Approaches To Stop HypertensionDietary SupplementsEatingFemaleHumansMaleMiddle Aged

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32635400

Citation

Kepka, Alina, et al. "Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease." Nutrients, vol. 12, no. 7, 2020.
Kepka A, Ochocinska A, Borzym-Kluczyk M, et al. Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease. Nutrients. 2020;12(7).
Kepka, A., Ochocinska, A., Borzym-Kluczyk, M., Skorupa, E., Stasiewicz-Jarocka, B., Chojnowska, S., & Waszkiewicz, N. (2020). Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease. Nutrients, 12(7). https://doi.org/10.3390/nu12071987
Kepka A, et al. Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease. Nutrients. 2020 Jul 3;12(7) PubMed PMID: 32635400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease. AU - Kepka,Alina, AU - Ochocinska,Agnieszka, AU - Borzym-Kluczyk,Małgorzata, AU - Skorupa,Ewa, AU - Stasiewicz-Jarocka,Beata, AU - Chojnowska,Sylwia, AU - Waszkiewicz,Napoleon, Y1 - 2020/07/03/ PY - 2020/06/03/received PY - 2020/06/25/revised PY - 2020/06/29/accepted PY - 2020/7/9/entrez PY - 2020/7/9/pubmed PY - 2021/2/25/medline KW - Alzheimer’s disease KW - L-carnitine KW - MIND diet KW - Mediterranean diet KW - carnitine supplementation JF - Nutrients JO - Nutrients VL - 12 IS - 7 N2 - The prevention or alleviation of neurodegenerative diseases, including Alzheimer's disease (AD), is a challenge for contemporary health services. The aim of this study was to review the literature on the prevention or alleviation of AD by introducing an appropriate carnitine-rich diet, dietary carnitine supplements and the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, which contains elements of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. L-carnitine (LC) plays a crucial role in the energetic metabolism of the cell. A properly balanced diet contains a substantial amount of LC as well as essential amino acids and microelements taking part in endogenous carnitine synthesis. In healthy people, carnitine biosynthesis is sufficient to prevent the symptoms of carnitine deficiency. In persons with dysfunction of mitochondria, e.g., with AD connected with extensive degeneration of the brain structures, there are often serious disturbances in the functioning of the whole organism. The Mediterranean diet is characterized by a high consumption of fruits and vegetables, cereals, nuts, olive oil, and seeds as the major source of fats, moderate consumption of fish and poultry, low to moderate consumption of dairy products and alcohol, and low intake of red and processed meat. The introduction of foodstuffs rich in carnitine and the MIND diet or carnitine supplementation of the AD patients may improve their functioning in everyday life. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32635400/Preventive_Role_of_L_Carnitine_and_Balanced_Diet_in_Alzheimer's_Disease_ DB - PRIME DP - Unbound Medicine ER -