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Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Biomolecules. 2020 Jul 05; 10(7)B

Abstract

Abstract: Currently, Angiostrongylus cantonensis infections are predominantly treated with albendazole. However, the use of albendazole can provoke certain neurological symptoms as a result of the immune response triggered by the dead worms. Therefore, treatment usually involves co-administration of corticosteroids to limit the inflammatory reaction. Corticosteroids play a useful role in suppressing inflammation in the brain; however, long-term usage or high dosage may make it problematic.Schisandrin B, an active ingredient from Schisandra chinensis, has been shown to have anti-inflammatory effects on the brain. This study aimed to investigate the effects and potential of schisandrin B in combination with albendazole to treat Angiostrongylus-induced meningoencephalitis. Here, we show that albendazole-schisandrin B co-treatment suppressed neuroinflammation in Angiostrongylus-infected mice and increased the survival of the mice. Accordingly, albendazole-schisandrin B co-treatment significantly inhibited inflammasome activation, pyroptosis, and apoptosis. The sensorimotor functions of the mice were also repaired after albendazole-schisandrin B treatment. Immune response was shown to shift from Th2 to Th1, which reduces inflammation and enhances immunity against A. cantonensis. Collectively, our study showed that albendazole-schisandrin B co-therapy may be used as an encouraging treatment for Angiostrongylus-induced meningoencephalitis.

Authors+Show Affiliations

Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan. Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan. Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32635653

Citation

Lam, Ho Yin Pekkle, et al. "Albendazole-Schisandrin B Co-Therapy On Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice." Biomolecules, vol. 10, no. 7, 2020.
Lam HYP, Liang TR, Jiang SJ, et al. Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice. Biomolecules. 2020;10(7).
Lam, H. Y. P., Liang, T. R., Jiang, S. J., & Peng, S. Y. (2020). Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice. Biomolecules, 10(7). https://doi.org/10.3390/biom10071001
Lam HYP, et al. Albendazole-Schisandrin B Co-Therapy On Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice. Biomolecules. 2020 Jul 5;10(7) PubMed PMID: 32635653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice. AU - Lam,Ho Yin Pekkle, AU - Liang,Ting-Ruei, AU - Jiang,Shinn-Jong, AU - Peng,Shih-Yi, Y1 - 2020/07/05/ PY - 2020/06/05/received PY - 2020/06/29/revised PY - 2020/07/02/accepted PY - 2020/7/9/entrez KW - Angiostrongylus KW - Schisandrin B KW - albendazole KW - anthelmintic drug KW - combination therapy KW - meningoencephalitis JF - Biomolecules JO - Biomolecules VL - 10 IS - 7 N2 - Abstract: Currently, Angiostrongylus cantonensis infections are predominantly treated with albendazole. However, the use of albendazole can provoke certain neurological symptoms as a result of the immune response triggered by the dead worms. Therefore, treatment usually involves co-administration of corticosteroids to limit the inflammatory reaction. Corticosteroids play a useful role in suppressing inflammation in the brain; however, long-term usage or high dosage may make it problematic.Schisandrin B, an active ingredient from Schisandra chinensis, has been shown to have anti-inflammatory effects on the brain. This study aimed to investigate the effects and potential of schisandrin B in combination with albendazole to treat Angiostrongylus-induced meningoencephalitis. Here, we show that albendazole-schisandrin B co-treatment suppressed neuroinflammation in Angiostrongylus-infected mice and increased the survival of the mice. Accordingly, albendazole-schisandrin B co-treatment significantly inhibited inflammasome activation, pyroptosis, and apoptosis. The sensorimotor functions of the mice were also repaired after albendazole-schisandrin B treatment. Immune response was shown to shift from Th2 to Th1, which reduces inflammation and enhances immunity against A. cantonensis. Collectively, our study showed that albendazole-schisandrin B co-therapy may be used as an encouraging treatment for Angiostrongylus-induced meningoencephalitis. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/32635653/Albendazole-Schisandrin_B_Co-Therapy_on_Angiostrongylus_cantonensis-Induced_Meningoencephalitis_in_Mice L2 - https://www.mdpi.com/resolver?pii=biom10071001 DB - PRIME DP - Unbound Medicine ER -
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