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A rapid fluorescent focus-inhibition test for determining the neutralizing-antibody response to lymphocytic choriomeningitis virus.
Can J Microbiol. 1977 May; 23(5):522-6.CJ

Abstract

Levels of neutralizing antibody to lymphocytic choriomeningitis (LCM) virus in the sera of 66 infected persons were assayed by a rapid fluorescent focus-inhibition test (RFFIT). The test was more sensitive than the mouse-neutralization (MN) test and could be completed in less than 24 h. The RFFIT titers were compared with titers obtained by the indirect fluorescent-antibody (IFA) and complement-fixation (CF) tests. Neutralizing antibody detected by the RFFIT remained positive after IRA, CF and MN antibodies had disappeared. The RFFIT for detection of LCM antibody is specific and reproducible and seems especially useful for determining the incidence and epidemiology of LCM virus infections.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

326357

Citation

Thacker, W L., et al. "A Rapid Fluorescent Focus-inhibition Test for Determining the Neutralizing-antibody Response to Lymphocytic Choriomeningitis Virus." Canadian Journal of Microbiology, vol. 23, no. 5, 1977, pp. 522-6.
Thacker WL, Lewis VJ, Haller GJ, et al. A rapid fluorescent focus-inhibition test for determining the neutralizing-antibody response to lymphocytic choriomeningitis virus. Can J Microbiol. 1977;23(5):522-6.
Thacker, W. L., Lewis, V. J., Haller, G. J., & Baer, G. M. (1977). A rapid fluorescent focus-inhibition test for determining the neutralizing-antibody response to lymphocytic choriomeningitis virus. Canadian Journal of Microbiology, 23(5), 522-6.
Thacker WL, et al. A Rapid Fluorescent Focus-inhibition Test for Determining the Neutralizing-antibody Response to Lymphocytic Choriomeningitis Virus. Can J Microbiol. 1977;23(5):522-6. PubMed PMID: 326357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A rapid fluorescent focus-inhibition test for determining the neutralizing-antibody response to lymphocytic choriomeningitis virus. AU - Thacker,W L, AU - Lewis,V J, AU - Haller,G J, AU - Baer,G M, PY - 1977/5/1/pubmed PY - 1977/5/1/medline PY - 1977/5/1/entrez SP - 522 EP - 6 JF - Canadian journal of microbiology JO - Can J Microbiol VL - 23 IS - 5 N2 - Levels of neutralizing antibody to lymphocytic choriomeningitis (LCM) virus in the sera of 66 infected persons were assayed by a rapid fluorescent focus-inhibition test (RFFIT). The test was more sensitive than the mouse-neutralization (MN) test and could be completed in less than 24 h. The RFFIT titers were compared with titers obtained by the indirect fluorescent-antibody (IFA) and complement-fixation (CF) tests. Neutralizing antibody detected by the RFFIT remained positive after IRA, CF and MN antibodies had disappeared. The RFFIT for detection of LCM antibody is specific and reproducible and seems especially useful for determining the incidence and epidemiology of LCM virus infections. SN - 0008-4166 UR - https://www.unboundmedicine.com/medline/citation/326357/A_rapid_fluorescent_focus_inhibition_test_for_determining_the_neutralizing_antibody_response_to_lymphocytic_choriomeningitis_virus_ L2 - https://cdnsciencepub.com/doi/10.1139/m77-077?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -