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Association between periodontitis and systemic lupus erythematosus: a meta-analysis.
Lupus. 2020 Sep; 29(10):1189-1197.L

Abstract

OBJECTIVE

The objective of this study was to explore the association between periodontitis and systemic lupus erythematosus (SLE).

METHODS

To identify eligible studies, the PubMed, EMBASE and Web of Science databases were searched from inception to 19 September 2019. Associations of periodontitis, and other periodontal parameters, with SLE were assessed.

RESULTS

Ten studies involving 80,633 subjects were included in this meta-analysis. Pooled data showed a significant association between periodontitis and SLE (odds ratio=5.32, 95% confidence interval (CI) 1.69-16.78, p = 0.004). In addition, SLE patients had a higher prevalence of bleeding on probing (mean difference = 0.03, 95% CI 0.00-0.06, p = 0.02) and higher mean clinical attachment loss (mean difference = 0.69, 95% CI 0.39-1.00, p < 0.001). However, there were no significant differences between SLE and reference subjects in mean plaque index, gingival index, pocket depth or decayed, missing or filled teeth.

CONCLUSIONS

This study demonstrates a significant association between periodontitis and SLE, which indicates that avoidance of periodontitis by maintaining oral health may be a simple and economical way to prevent SLE.

Authors+Show Affiliations

Guangdong Medical University, Zhanjiang, PR China. The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, PR China.Guangdong Medical University, Zhanjiang, PR China.The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, PR China.The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32635879

Citation

Zhong, Hao-Jie, et al. "Association Between Periodontitis and Systemic Lupus Erythematosus: a Meta-analysis." Lupus, vol. 29, no. 10, 2020, pp. 1189-1197.
Zhong HJ, Xie HX, Luo XM, et al. Association between periodontitis and systemic lupus erythematosus: a meta-analysis. Lupus. 2020;29(10):1189-1197.
Zhong, H. J., Xie, H. X., Luo, X. M., & Zhang, E. H. (2020). Association between periodontitis and systemic lupus erythematosus: a meta-analysis. Lupus, 29(10), 1189-1197. https://doi.org/10.1177/0961203320938447
Zhong HJ, et al. Association Between Periodontitis and Systemic Lupus Erythematosus: a Meta-analysis. Lupus. 2020;29(10):1189-1197. PubMed PMID: 32635879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between periodontitis and systemic lupus erythematosus: a meta-analysis. AU - Zhong,Hao-Jie, AU - Xie,Hui-Xin, AU - Luo,Xiao-Min, AU - Zhang,Er-Hua, Y1 - 2020/07/07/ PY - 2020/7/9/pubmed PY - 2020/7/9/medline PY - 2020/7/9/entrez KW - Periodontitis KW - bacteria KW - meta-analysis KW - systemic lupus erythematosus SP - 1189 EP - 1197 JF - Lupus JO - Lupus VL - 29 IS - 10 N2 - OBJECTIVE: The objective of this study was to explore the association between periodontitis and systemic lupus erythematosus (SLE). METHODS: To identify eligible studies, the PubMed, EMBASE and Web of Science databases were searched from inception to 19 September 2019. Associations of periodontitis, and other periodontal parameters, with SLE were assessed. RESULTS: Ten studies involving 80,633 subjects were included in this meta-analysis. Pooled data showed a significant association between periodontitis and SLE (odds ratio=5.32, 95% confidence interval (CI) 1.69-16.78, p = 0.004). In addition, SLE patients had a higher prevalence of bleeding on probing (mean difference = 0.03, 95% CI 0.00-0.06, p = 0.02) and higher mean clinical attachment loss (mean difference = 0.69, 95% CI 0.39-1.00, p < 0.001). However, there were no significant differences between SLE and reference subjects in mean plaque index, gingival index, pocket depth or decayed, missing or filled teeth. CONCLUSIONS: This study demonstrates a significant association between periodontitis and SLE, which indicates that avoidance of periodontitis by maintaining oral health may be a simple and economical way to prevent SLE. SN - 1477-0962 UR - https://www.unboundmedicine.com/medline/citation/32635879/Association_between_periodontitis_and_systemic_lupus_erythematosus:_a_meta-analysis L2 - https://journals.sagepub.com/doi/10.1177/0961203320938447?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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