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[Unusual serum protein electrophoresis in a patient with cholangiocarcinoma].
Pan Afr Med J. 2020; 35:117.PA

Abstract

Serum protein electrophoresis is of certain diagnostic interest. We report a case of unusual electrophoresis associated with cholestatic jaundice complicating a cholangiocarcinoma. The study involved a 55-year old patient hospitalized for the exploration of cholestatic jaundice. Capillary electrophoresis showed bisalbuminemia diagnosed based on the thickening of the bottom of the albumin peak and a supernumerary peak X. Second electrophoresis with Hydragel showed the disappearance of the two above abnormalities which was the proof that bisalbuminemia was acquired and of the lipidic nature of the Pic X. In our case, the most likely cause was the presence of interfering substances such as free bilirubin (hyperbilirubinemia), lipids (hyperlipidaemia) and bile acids. Bisalbuminemia in a patient with similar electrophoretic picture should suggest the search for underlying diseases.

Authors+Show Affiliations

Université des Sciences, des Techniques, des Technologies de Bamako (USTTB), Faculté de Pharmacie, Bamako, Mali.Laboratoire d'Analyses Médicale Algi, Quinzambougou, Bamako, Mali.UFR Sciences de la Santé, Université Ouaga Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.Laboratoire d'Analyses Médicale Algi, Quinzambougou, Bamako, Mali.Laboratoire d'Analyses Médicale Algi, Quinzambougou, Bamako, Mali.Laboratoire d'Analyses Médicale Algi, Quinzambougou, Bamako, Mali.Laboratoire d'Analyses Médicale Algi, Quinzambougou, Bamako, Mali.Laboratoire d'Analyses Médicale Algi, Quinzambougou, Bamako, Mali.

Pub Type(s)

Case Reports
English Abstract

Language

fre

PubMed ID

32637015

Citation

Bissan, Aboubacar Dit Tietie, et al. "[Unusual Serum Protein Electrophoresis in a Patient With Cholangiocarcinoma]." The Pan African Medical Journal, vol. 35, 2020, p. 117.
Bissan ADT, Diawara A, Karfo R, et al. [Unusual serum protein electrophoresis in a patient with cholangiocarcinoma]. Pan Afr Med J. 2020;35:117.
Bissan, A. D. T., Diawara, A., Karfo, R., Teguete, A., Tangara, O., Guindo, A., Maïga, F., & Algiman, E. (2020). [Unusual serum protein electrophoresis in a patient with cholangiocarcinoma]. The Pan African Medical Journal, 35, 117. https://doi.org/10.11604/pamj.2020.35.117.20616
Bissan ADT, et al. [Unusual Serum Protein Electrophoresis in a Patient With Cholangiocarcinoma]. Pan Afr Med J. 2020;35:117. PubMed PMID: 32637015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Unusual serum protein electrophoresis in a patient with cholangiocarcinoma]. AU - Bissan,Aboubacar Dit Tietie, AU - Diawara,Amadou, AU - Karfo,Raoul, AU - Teguete,Aboubakre, AU - Tangara,Oumar, AU - Guindo,Alpha, AU - Maïga,Fatoumata, AU - Algiman,Etienne, Y1 - 2020/04/14/ PY - 2019/10/11/received PY - 2019/10/23/accepted PY - 2020/7/9/entrez PY - 2020/7/9/pubmed PY - 2020/7/9/medline SP - 117 EP - 117 JF - The Pan African medical journal JO - Pan Afr Med J VL - 35 N2 - Serum protein electrophoresis is of certain diagnostic interest. We report a case of unusual electrophoresis associated with cholestatic jaundice complicating a cholangiocarcinoma. The study involved a 55-year old patient hospitalized for the exploration of cholestatic jaundice. Capillary electrophoresis showed bisalbuminemia diagnosed based on the thickening of the bottom of the albumin peak and a supernumerary peak X. Second electrophoresis with Hydragel showed the disappearance of the two above abnormalities which was the proof that bisalbuminemia was acquired and of the lipidic nature of the Pic X. In our case, the most likely cause was the presence of interfering substances such as free bilirubin (hyperbilirubinemia), lipids (hyperlipidaemia) and bile acids. Bisalbuminemia in a patient with similar electrophoretic picture should suggest the search for underlying diseases. SN - 1937-8688 UR - https://www.unboundmedicine.com/medline/citation/32637015/[Unusual_serum_protein_electrophoresis_in_a_patient_with_cholangiocarcinoma] L2 - https://www.panafrican-med-journal.com/content/article/35/117/full/ DB - PRIME DP - Unbound Medicine ER -
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