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The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context.
Arrhythm Electrophysiol Rev. 2020 Jun 03; 9(1):34-39.AE

Abstract

The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation: Double Short vs Standard Exposure Duration (CIRCA-DOSE) study was a multicentre, randomised, single-blinded trial that compared contact-force radiofrequency ablation and two different regimens of cryoballoon ablation. All patients received an implantable cardiac monitor for the purpose of continuous rhythm monitoring, with all arrhythmia events undergoing independent adjudication by a committee blinded to treatment allocation. The study demonstrated there were no significant differences between contact-force radiofrequency ablation and cryoballoon ablation with respect to recurrence of any atrial tachyarrhythmia, symptomatic atrial tachyarrhythmia, asymptomatic AF, symptomatic AF or AF burden. While the results of the CIRCA-DOSE study are reviewed here, this article focuses on considerations around the design of the study and places the observed outcomes in context.

Authors+Show Affiliations

Montreal Heart Institute, Department of Medicine, University of Montreal, Montreal, Canada. Heart Rhythm Services, Department of Medicine, University of British Columbia, Canada.Heart Rhythm Services, Department of Medicine, University of British Columbia, Canada.Southlake Regional Health Center, Newmarket, Canada.Montreal Heart Institute, Department of Medicine, University of Montreal, Montreal, Canada.Montreal Heart Institute, Department of Medicine, University of Montreal, Montreal, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32637118

Citation

Andrade, Jason G., et al. "The Cryoballoon Vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context." Arrhythmia & Electrophysiology Review, vol. 9, no. 1, 2020, pp. 34-39.
Andrade JG, Deyell MW, Verma A, et al. The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context. Arrhythm Electrophysiol Rev. 2020;9(1):34-39.
Andrade, J. G., Deyell, M. W., Verma, A., Macle, L., & Khairy, P. (2020). The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context. Arrhythmia & Electrophysiology Review, 9(1), 34-39. https://doi.org/10.15420/aer.2019.13
Andrade JG, et al. The Cryoballoon Vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context. Arrhythm Electrophysiol Rev. 2020 Jun 3;9(1):34-39. PubMed PMID: 32637118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation (CIRCA-DOSE) Study Results in Context. AU - Andrade,Jason G, AU - Deyell,Marc W, AU - Verma,Atul, AU - Macle,Laurent, AU - Khairy,Paul, PY - 2020/7/9/entrez PY - 2020/7/9/pubmed PY - 2020/7/9/medline KW - AF KW - ablation KW - cryoablation KW - implantable cardiac monitor KW - implantable loop recorder KW - pulmonary vein isolation KW - radiofrequency SP - 34 EP - 39 JF - Arrhythmia & electrophysiology review JO - Arrhythm Electrophysiol Rev VL - 9 IS - 1 N2 - The Cryoballoon vs Irrigated Radiofrequency Catheter Ablation: Double Short vs Standard Exposure Duration (CIRCA-DOSE) study was a multicentre, randomised, single-blinded trial that compared contact-force radiofrequency ablation and two different regimens of cryoballoon ablation. All patients received an implantable cardiac monitor for the purpose of continuous rhythm monitoring, with all arrhythmia events undergoing independent adjudication by a committee blinded to treatment allocation. The study demonstrated there were no significant differences between contact-force radiofrequency ablation and cryoballoon ablation with respect to recurrence of any atrial tachyarrhythmia, symptomatic atrial tachyarrhythmia, asymptomatic AF, symptomatic AF or AF burden. While the results of the CIRCA-DOSE study are reviewed here, this article focuses on considerations around the design of the study and places the observed outcomes in context. SN - 2050-3369 UR - https://www.unboundmedicine.com/medline/citation/32637118/The_Cryoballoon_vs_Irrigated_Radiofrequency_Catheter_Ablation_(CIRCA-DOSE)_Study_Results_in_Context L2 - https://doi.org/10.15420/aer.2019.13 DB - PRIME DP - Unbound Medicine ER -
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