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High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton.
J Cell Mol Med. 2020 Jul 08 [Online ahead of print]JC

Abstract

Abnormal expression of neuropilin and tolloid-like 1 (NETO1) has been detected in some human carcinomas. However, the expression of NETO1 and the underlying mechanism in epithelial ovarian cancer (EOC) remain unknown. In this study, we found that a higher NETO1 expression in EOC tissue samples compared to normal ovarian tissue samples was significantly correlated with worse overall survival. Additionally, Cox regression analysis suggested that NETO 1 was independently associated with overall survival. NETO1 overexpression enhanced the EOC cells' migration and invasion capability in vitro via regulation of actin cytoskeleton. Mechanistically, silencing NETO1 reduced the expression of β-tubulin, F-actin and KIF2A. In conclusion, our results demonstrated the critical role of NETO1 in EOC invasion, and therapies aimed at inhibiting its expression or activity might significantly control EOC growth, invasion and metastatic dissemination.

Authors+Show Affiliations

Department of Clinical Biobank, Affiliated Hospital of Nantong University, Nantong, China.Department of Clinical Biobank, Affiliated Hospital of Nantong University, Nantong, China.Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, China.Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32638511

Citation

Xu, Yunzhao, et al. "High Neuropilin and Tolloid-like 1 Expression Associated With Metastasis and Poor Survival in Epithelial Ovarian Cancer Via Regulation of Actin Cytoskeleton." Journal of Cellular and Molecular Medicine, 2020.
Xu Y, Wang W, Chen J, et al. High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton. J Cell Mol Med. 2020.
Xu, Y., Wang, W., Chen, J., Mao, H., Liu, Y., Gu, S., Liu, Q., Xi, Q., & Shi, W. (2020). High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton. Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/jcmm.15547
Xu Y, et al. High Neuropilin and Tolloid-like 1 Expression Associated With Metastasis and Poor Survival in Epithelial Ovarian Cancer Via Regulation of Actin Cytoskeleton. J Cell Mol Med. 2020 Jul 8; PubMed PMID: 32638511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton. AU - Xu,Yunzhao, AU - Wang,Wei, AU - Chen,Jinling, AU - Mao,Haixia, AU - Liu,Yuanlin, AU - Gu,Shuting, AU - Liu,Qinqin, AU - Xi,Qinghua, AU - Shi,Wenyu, Y1 - 2020/07/08/ PY - 2020/02/04/received PY - 2020/06/01/revised PY - 2020/06/07/accepted PY - 2020/7/9/entrez PY - 2020/7/9/pubmed PY - 2020/7/9/medline KW - KIF2A KW - NETO1 KW - actin cytoskeleton KW - bioinformation KW - epithelial ovarian cancer JF - Journal of cellular and molecular medicine JO - J. Cell. Mol. Med. N2 - Abnormal expression of neuropilin and tolloid-like 1 (NETO1) has been detected in some human carcinomas. However, the expression of NETO1 and the underlying mechanism in epithelial ovarian cancer (EOC) remain unknown. In this study, we found that a higher NETO1 expression in EOC tissue samples compared to normal ovarian tissue samples was significantly correlated with worse overall survival. Additionally, Cox regression analysis suggested that NETO 1 was independently associated with overall survival. NETO1 overexpression enhanced the EOC cells' migration and invasion capability in vitro via regulation of actin cytoskeleton. Mechanistically, silencing NETO1 reduced the expression of β-tubulin, F-actin and KIF2A. In conclusion, our results demonstrated the critical role of NETO1 in EOC invasion, and therapies aimed at inhibiting its expression or activity might significantly control EOC growth, invasion and metastatic dissemination. SN - 1582-4934 UR - https://www.unboundmedicine.com/medline/citation/32638511/High_neuropilin_and_tolloid-like_1_expression_associated_with_metastasis_and_poor_survival_in_epithelial_ovarian_cancer_via_regulation_of_actin_cytoskeleton L2 - https://doi.org/10.1111/jcmm.15547 DB - PRIME DP - Unbound Medicine ER -
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