Tags

Type your tag names separated by a space and hit enter

The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects.
Bone Miner 1988; 4(1):105-13BM

Abstract

The effects of 40 mg of prednisone given daily for 5 days to normal individuals on serum levels of bone Gla-protein (BGP), alkaline phosphatase, calcium phosphate, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone (S-iPTH) and on renal excretions of calcium, phosphate and hydroxyproline were evaluated in a double-blind, placebo controlled study. In the prednisone group a 75% decrease (P less than 0.001) was found in serum BGP compared to a 6% decrease (P less than 0.05) in serum alkaline phosphatase. The renal hydroxyproline excretion remained unchanged. Serum calcium was unchanged while the fasting urinary calcium excretion showed a 2-fold increase (P less than 0.001). Serum 1,25-dihydroxyvitamin D increased (P less than 0.01) in spite of unchanged serum 25-hydroxyvitamin D, serum phosphate and parathyroid function (as judged by S-iPTH and the maximal tubular reabsorption capacity for phosphate (TmP/GFR]. The data suggest a direct inhibition of osteoblast number and/or function by short-term glucocorticoid administration with unchanged bone resorption leading to a negative bone mineral balance. The increase in serum 1,25-dihydroxyvitamin D is probably due to a direct stimulation by glucocorticoids of the renal 1 alpha-hydroxylase. The effects of the vitamin D metabolite, however seem to be blunted.

Authors+Show Affiliations

Medical Department III, Arhus Amtssygehus, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3263890

Citation

Nielsen, H K., et al. "The Effects of High-dose Glucocorticoid Administration On Serum Bone Gamma Carboxyglutamic Acid-containing Protein, Serum Alkaline Phosphatase and Vitamin D Metabolites in Normal Subjects." Bone and Mineral, vol. 4, no. 1, 1988, pp. 105-13.
Nielsen HK, Thomsen K, Eriksen EF, et al. The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects. Bone Miner. 1988;4(1):105-13.
Nielsen, H. K., Thomsen, K., Eriksen, E. F., Charles, P., Storm, T., & Mosekilde, L. (1988). The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects. Bone and Mineral, 4(1), pp. 105-13.
Nielsen HK, et al. The Effects of High-dose Glucocorticoid Administration On Serum Bone Gamma Carboxyglutamic Acid-containing Protein, Serum Alkaline Phosphatase and Vitamin D Metabolites in Normal Subjects. Bone Miner. 1988;4(1):105-13. PubMed PMID: 3263890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects. AU - Nielsen,H K, AU - Thomsen,K, AU - Eriksen,E F, AU - Charles,P, AU - Storm,T, AU - Mosekilde,L, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 105 EP - 13 JF - Bone and mineral JO - Bone Miner VL - 4 IS - 1 N2 - The effects of 40 mg of prednisone given daily for 5 days to normal individuals on serum levels of bone Gla-protein (BGP), alkaline phosphatase, calcium phosphate, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone (S-iPTH) and on renal excretions of calcium, phosphate and hydroxyproline were evaluated in a double-blind, placebo controlled study. In the prednisone group a 75% decrease (P less than 0.001) was found in serum BGP compared to a 6% decrease (P less than 0.05) in serum alkaline phosphatase. The renal hydroxyproline excretion remained unchanged. Serum calcium was unchanged while the fasting urinary calcium excretion showed a 2-fold increase (P less than 0.001). Serum 1,25-dihydroxyvitamin D increased (P less than 0.01) in spite of unchanged serum 25-hydroxyvitamin D, serum phosphate and parathyroid function (as judged by S-iPTH and the maximal tubular reabsorption capacity for phosphate (TmP/GFR]. The data suggest a direct inhibition of osteoblast number and/or function by short-term glucocorticoid administration with unchanged bone resorption leading to a negative bone mineral balance. The increase in serum 1,25-dihydroxyvitamin D is probably due to a direct stimulation by glucocorticoids of the renal 1 alpha-hydroxylase. The effects of the vitamin D metabolite, however seem to be blunted. SN - 0169-6009 UR - https://www.unboundmedicine.com/medline/citation/3263890/The_effects_of_high_dose_glucocorticoid_administration_on_serum_bone_gamma_carboxyglutamic_acid_containing_protein_serum_alkaline_phosphatase_and_vitamin_D_metabolites_in_normal_subjects_ L2 - https://medlineplus.gov/vitamind.html DB - PRIME DP - Unbound Medicine ER -