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Searching predictive factors of efficacy and safety in a fractional CO2 laser.
Dermatol Ther. 2020 Jul 08 [Online ahead of print]DT

Abstract

A few studies discussed short outcomes in fractional CO2 laser. This study aimed to seek factors of medium-term efficacy and safety in patients treated for facial rejuvenation or acne scars. This single-center, prospective, single-arm, evaluator-blinded cohort study included patients of 18 years and older undergoing a fractional CO2 laser for facial skin rejuvenation or atrophic acne scars. One session of ultrapulsed fractional 10 600 nm CO2 laser was performed with the Deep FX TM mode in acne scars and the Active FX TM mode in facial rejuvenation and acne scars. Follow-up was carried out for 6 months. In the end, a patient self-satisfaction assessment was obtained. A blinded physician graded improvement based on pretreatment and 6-month photography. The study included 75 patients, of whom 88% were women. Forty-five had facial rejuvenation, and 30 had atrophic acne scars treatment. Half of the patients were satisfied. The physician-blinded evaluation indicated "good to very good" improvement in 46.7% of facial rejuvenation patients, and 30% of acne scars patients. Hyperpigmentation and folliculitis were recorded in 15 and 3 patients, respectively. This study did not find statistically significant factors to predict outcomes in a fractional CO2 laser. We could however note better results in acne scar patients of thicker skin, and facial rejuvenation patients of younger age and thinner skin. We counted more hyperpigmentation events in phototypes III and IV, and it was reversible in all cases.

Authors+Show Affiliations

School of Medicine, Université Saint-Joseph, Beirut, Lebanon. Department of Dermatology, Hôtel-Dieu de France Hospital, Beirut, Lebanon.Private Dermatology Clinic, Byblos, Lebanon.School of Medicine, Université Saint-Joseph, Beirut, Lebanon. Department of Dermatology, Hôtel-Dieu de France Hospital, Beirut, Lebanon.School of Medicine, Université Saint-Joseph, Beirut, Lebanon. Department of Dermatology, Hôtel-Dieu de France Hospital, Beirut, Lebanon.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32639071

Citation

Helou, Josiane, et al. "Searching Predictive Factors of Efficacy and Safety in a Fractional CO2 Laser." Dermatologic Therapy, 2020, pp. e13985.
Helou J, Korkomaz J, Stephan F, et al. Searching predictive factors of efficacy and safety in a fractional CO2 laser. Dermatol Ther. 2020.
Helou, J., Korkomaz, J., Stephan, F., & Soutou, B. (2020). Searching predictive factors of efficacy and safety in a fractional CO2 laser. Dermatologic Therapy, e13985. https://doi.org/10.1111/dth.13985
Helou J, et al. Searching Predictive Factors of Efficacy and Safety in a Fractional CO2 Laser. Dermatol Ther. 2020 Jul 8;e13985. PubMed PMID: 32639071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Searching predictive factors of efficacy and safety in a fractional CO2 laser. AU - Helou,Josiane, AU - Korkomaz,Joelle, AU - Stephan,Farid, AU - Soutou,Boutros, Y1 - 2020/07/08/ PY - 2020/06/21/received PY - 2020/06/26/revised PY - 2020/07/06/accepted PY - 2020/7/9/pubmed PY - 2020/7/9/medline PY - 2020/7/9/entrez KW - acne scar KW - complication KW - facial rejuvenation KW - fractional CO2 laser SP - e13985 EP - e13985 JF - Dermatologic therapy JO - Dermatol Ther N2 - A few studies discussed short outcomes in fractional CO2 laser. This study aimed to seek factors of medium-term efficacy and safety in patients treated for facial rejuvenation or acne scars. This single-center, prospective, single-arm, evaluator-blinded cohort study included patients of 18 years and older undergoing a fractional CO2 laser for facial skin rejuvenation or atrophic acne scars. One session of ultrapulsed fractional 10 600 nm CO2 laser was performed with the Deep FX TM mode in acne scars and the Active FX TM mode in facial rejuvenation and acne scars. Follow-up was carried out for 6 months. In the end, a patient self-satisfaction assessment was obtained. A blinded physician graded improvement based on pretreatment and 6-month photography. The study included 75 patients, of whom 88% were women. Forty-five had facial rejuvenation, and 30 had atrophic acne scars treatment. Half of the patients were satisfied. The physician-blinded evaluation indicated "good to very good" improvement in 46.7% of facial rejuvenation patients, and 30% of acne scars patients. Hyperpigmentation and folliculitis were recorded in 15 and 3 patients, respectively. This study did not find statistically significant factors to predict outcomes in a fractional CO2 laser. We could however note better results in acne scar patients of thicker skin, and facial rejuvenation patients of younger age and thinner skin. We counted more hyperpigmentation events in phototypes III and IV, and it was reversible in all cases. SN - 1529-8019 UR - https://www.unboundmedicine.com/medline/citation/32639071/Searching_predictive_factors_of_efficacy_and_safety_in_a_fractional_CO2_laser L2 - https://doi.org/10.1111/dth.13985 DB - PRIME DP - Unbound Medicine ER -
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