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COVID-19 and the Chemical Senses: Supporting Players Take Center Stage.
Neuron. 2020 07 22; 107(2):219-233.N

Abstract

The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.

Links

Publisher Full Text
ncbi.nlm.nih.gov
linkinghub.elsevier.com
PMC Free PDF

Authors+Show Affiliations

Cooper KW
Interdepartmental Neuroscience Program, University of California Irvine, Irvine, CA, USA.
Brann DH
Harvard Medical School Department of Neurobiology, Boston, MA, USA.
Farruggia MC
Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA.
Bhutani S
School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA.
Pellegrino R
Department of Food Science, Institute of Agriculture, University of Tennessee, Knoxville, TN, USA; Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
Tsukahara T
Harvard Medical School Department of Neurobiology, Boston, MA, USA.
Weinreb C
Harvard Medical School Department of Neurobiology, Boston, MA, USA.
Joseph PV
Division of Intramural Research, National Institute of Nursing Research (NINR) National Institutes of Health, Bethesda, MD, USA; National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health, Bethesda, MD, USA.
Larson ED
Department of Otolaryngology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA and the Rocky Mountain Taste and Smell Center, Aurora, CO, USA.
Parma V
Department of Psychology, Temple University, Philadelphia, PA, USA.
Albers MW
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Barlow LA
Department of Cell and Developmental Biology, Graduate Program in Cell Biology, Stem Cells and Development and the Rocky Mountain Taste and Smell Center, University of Colorado, School Medicine, Anschutz Medical Campus, Aurora, CO, USA. Electronic address: linda.barlow@cuanschutz.edu.
Datta SR
Harvard Medical School Department of Neurobiology, Boston, MA, USA. Electronic address: srdatta@hms.harvard.edu.
Di Pizio A
Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising, Germany. Electronic address: a.dipizio.leibniz-lsb@tum.de.

MeSH

AnimalsBetacoronavirusCOVID-19Coronavirus InfectionsHumansOlfaction DisordersOlfactory BulbOlfactory MucosaPandemicsPneumonia, ViralSARS-CoV-2SmellTasteTaste Disorders

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32640192

Citation

Cooper, Keiland W., et al. "COVID-19 and the Chemical Senses: Supporting Players Take Center Stage." Neuron, vol. 107, no. 2, 2020, pp. 219-233.
Cooper KW, Brann DH, Farruggia MC, et al. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020;107(2):219-233.
Cooper, K. W., Brann, D. H., Farruggia, M. C., Bhutani, S., Pellegrino, R., Tsukahara, T., Weinreb, C., Joseph, P. V., Larson, E. D., Parma, V., Albers, M. W., Barlow, L. A., Datta, S. R., & Di Pizio, A. (2020). COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron, 107(2), 219-233. https://doi.org/10.1016/j.neuron.2020.06.032
Cooper KW, et al. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020 07 22;107(2):219-233. PubMed PMID: 32640192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. AU - Cooper,Keiland W, AU - Brann,David H, AU - Farruggia,Michael C, AU - Bhutani,Surabhi, AU - Pellegrino,Robert, AU - Tsukahara,Tatsuya, AU - Weinreb,Caleb, AU - Joseph,Paule V, AU - Larson,Eric D, AU - Parma,Valentina, AU - Albers,Mark W, AU - Barlow,Linda A, AU - Datta,Sandeep Robert, AU - Di Pizio,Antonella, Y1 - 2020/07/01/ PY - 2020/05/22/received PY - 2020/06/24/revised PY - 2020/06/25/accepted PY - 2020/7/9/pubmed PY - 2020/8/5/medline PY - 2020/7/9/entrez SP - 219 EP - 233 JF - Neuron JO - Neuron VL - 107 IS - 2 N2 - The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly. SN - 1097-4199 UR - https://www.unboundmedicine.com/medline/citation/32640192/COVID_19_and_the_Chemical_Senses:_Supporting_Players_Take_Center_Stage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(20)30486-4 DB - PRIME DP - Unbound Medicine ER -