COVID-19 and the Chemical Senses: Supporting Players Take Center Stage.Neuron. 2020 07 22; 107(2):219-233.N
Abstract
The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.
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Publisher Full Text
MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Language
eng
PubMed ID
32640192
Citation
Cooper, Keiland W., et al. "COVID-19 and the Chemical Senses: Supporting Players Take Center Stage." Neuron, vol. 107, no. 2, 2020, pp. 219-233.
Cooper KW, Brann DH, Farruggia MC, et al. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020;107(2):219-233.
Cooper, K. W., Brann, D. H., Farruggia, M. C., Bhutani, S., Pellegrino, R., Tsukahara, T., Weinreb, C., Joseph, P. V., Larson, E. D., Parma, V., Albers, M. W., Barlow, L. A., Datta, S. R., & Di Pizio, A. (2020). COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron, 107(2), 219-233. https://doi.org/10.1016/j.neuron.2020.06.032
Cooper KW, et al. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020 07 22;107(2):219-233. PubMed PMID: 32640192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - COVID-19 and the Chemical Senses: Supporting Players Take Center Stage.
AU - Cooper,Keiland W,
AU - Brann,David H,
AU - Farruggia,Michael C,
AU - Bhutani,Surabhi,
AU - Pellegrino,Robert,
AU - Tsukahara,Tatsuya,
AU - Weinreb,Caleb,
AU - Joseph,Paule V,
AU - Larson,Eric D,
AU - Parma,Valentina,
AU - Albers,Mark W,
AU - Barlow,Linda A,
AU - Datta,Sandeep Robert,
AU - Di Pizio,Antonella,
Y1 - 2020/07/01/
PY - 2020/05/22/received
PY - 2020/06/24/revised
PY - 2020/06/25/accepted
PY - 2020/7/9/pubmed
PY - 2020/8/5/medline
PY - 2020/7/9/entrez
SP - 219
EP - 233
JF - Neuron
JO - Neuron
VL - 107
IS - 2
N2 - The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.
SN - 1097-4199
UR - https://www.unboundmedicine.com/medline/citation/32640192/COVID_19_and_the_Chemical_Senses:_Supporting_Players_Take_Center_Stage_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(20)30486-4
DB - PRIME
DP - Unbound Medicine
ER -