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Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting.
Cells. 2020 Jul 06; 9(7)C

Abstract

Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design.

Authors+Show Affiliations

Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland. Department of Biochemistry, University of Turku, 20520 Turku, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32640605

Citation

Conway, James Ronald William, et al. "Kinase-Independent Functions of MASTL in Cancer: a New Perspective On MASTL Targeting." Cells, vol. 9, no. 7, 2020.
Conway JRW, Närvä E, Taskinen ME, et al. Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting. Cells. 2020;9(7).
Conway, J. R. W., Närvä, E., Taskinen, M. E., & Ivaska, J. (2020). Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting. Cells, 9(7). https://doi.org/10.3390/cells9071624
Conway JRW, et al. Kinase-Independent Functions of MASTL in Cancer: a New Perspective On MASTL Targeting. Cells. 2020 Jul 6;9(7) PubMed PMID: 32640605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting. AU - Conway,James Ronald William, AU - Närvä,Elisa, AU - Taskinen,Maria Emilia, AU - Ivaska,Johanna, Y1 - 2020/07/06/ PY - 2020/06/01/received PY - 2020/06/29/revised PY - 2020/07/01/accepted PY - 2020/7/10/entrez KW - MASTL KW - actin KW - cancer KW - cell cycle KW - contractility KW - kinase inhibitor KW - therapeutic targeting JF - Cells JO - Cells VL - 9 IS - 7 N2 - Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/32640605/Kinase-Independent_Functions_of_MASTL_in_Cancer:_A_New_Perspective_on_MASTL_Targeting L2 - https://www.mdpi.com/resolver?pii=cells9071624 DB - PRIME DP - Unbound Medicine ER -
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