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The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application.
Materials (Basel). 2020 Jul 06; 13(13)M

Abstract

The investigation of innovative label-free α-amino acids detection methods represents a crucial step for the early diagnosis of several diseases. While 1,8-diazafluoren-9-one (DFO) is known in forensic application because of the fluorescent products by reacting with the amino acids present in the papillary exudate, its application for diagnostic purposes has not been fully investigated. The stabilization of DFO over a transparent substrate allows its complexation with biomolecules for the detection of α-amino acids. In this study, DFO was immobilized into a titanium dioxide (TiO2) matrix for the fluorescence detection of glycine, as a target α-amino acid (a potential marker of the urogenital tract cancers). The DFO/TiO2 composite was characterized by atomic force microscopy, spectroscopic ellipsometry, fluorescence spectroscopy and fluorescence microscopy. The performed fluorescent studies indicate spectacular formation of aggregates at higher concentration. The measurements performed using various fluorescence and microscopic techniques together with the suitable analysis show that the aggregates are able to emit short-lived fluorescence.

Authors+Show Affiliations

Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland.Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Gabriela Narutowicza Street, 80-233 Gdańsk, Poland.Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland.Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Gabriela Narutowicza Street, 80-233 Gdańsk, Poland.Faculty of Microbiology, Immunology and Genetics, Health Science Center, University of North Texas, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland.Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland.Faculty of Applied Physics, Gdańsk University of Technology 11/12 Gabriela Narutowicza Street, 80-233 Gdańsk, Poland.Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. Hallera 107, 80-416 Gdańsk, Poland.Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. Hallera 107, 80-416 Gdańsk, Poland.Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. Hallera 107, 80-416 Gdańsk, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32640655

Citation

Lewkowicz, Aneta, et al. "The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application." Materials (Basel, Switzerland), vol. 13, no. 13, 2020.
Lewkowicz A, Bogdanowicz R, Bojarski P, et al. The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application. Materials (Basel). 2020;13(13).
Lewkowicz, A., Bogdanowicz, R., Bojarski, P., Pierpaoli, M., Gryczyński, I., Synak, A., Mońka, M., Karczewski, J., Struck-Lewicka, W., Wawrzyniak, R., & Markuszewski, M. J. (2020). The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application. Materials (Basel, Switzerland), 13(13). https://doi.org/10.3390/ma13133014
Lewkowicz A, et al. The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application. Materials (Basel). 2020 Jul 6;13(13) PubMed PMID: 32640655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application. AU - Lewkowicz,Aneta, AU - Bogdanowicz,Robert, AU - Bojarski,Piotr, AU - Pierpaoli,Mattia, AU - Gryczyński,Ignacy, AU - Synak,Anna, AU - Mońka,Michał, AU - Karczewski,Jakub, AU - Struck-Lewicka,Wiktoria, AU - Wawrzyniak,Renata, AU - Markuszewski,Michał J, Y1 - 2020/07/06/ PY - 2020/05/28/received PY - 2020/07/01/revised PY - 2020/07/03/accepted PY - 2020/7/10/entrez PY - 2020/7/10/pubmed PY - 2020/7/10/medline KW - DFO KW - TiO2 KW - thin films JF - Materials (Basel, Switzerland) JO - Materials (Basel) VL - 13 IS - 13 N2 - The investigation of innovative label-free α-amino acids detection methods represents a crucial step for the early diagnosis of several diseases. While 1,8-diazafluoren-9-one (DFO) is known in forensic application because of the fluorescent products by reacting with the amino acids present in the papillary exudate, its application for diagnostic purposes has not been fully investigated. The stabilization of DFO over a transparent substrate allows its complexation with biomolecules for the detection of α-amino acids. In this study, DFO was immobilized into a titanium dioxide (TiO2) matrix for the fluorescence detection of glycine, as a target α-amino acid (a potential marker of the urogenital tract cancers). The DFO/TiO2 composite was characterized by atomic force microscopy, spectroscopic ellipsometry, fluorescence spectroscopy and fluorescence microscopy. The performed fluorescent studies indicate spectacular formation of aggregates at higher concentration. The measurements performed using various fluorescence and microscopic techniques together with the suitable analysis show that the aggregates are able to emit short-lived fluorescence. SN - 1996-1944 UR - https://www.unboundmedicine.com/medline/citation/32640655/The_Luminescence_of_1,8-Diazafluoren-9-One/Titanium_Dioxide_Composite_Thin_Films_for_Optical_Application L2 - https://www.mdpi.com/resolver?pii=ma13133014 DB - PRIME DP - Unbound Medicine ER -
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