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Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China.
BMC Pregnancy Childbirth. 2020 Jul 08; 20(1):394.BP

Abstract

BACKGROUND

Compared with Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hope to provide some references for obstetric treatment and management.

METHODS

A total of 18 patients with COVID-19 treated at Renmin Hospital of Wuhan University were collected. The epidemiological characteristics, clinical manifestations, laboratory tests, chest CT and pregnancy outcomes were performed for analysis.

RESULTS

1. 18 cases of late pregnancy infected with SARS-CoV-2 pneumonia were delivered at 35 + 5 weeks to 41 weeks. According to the clinical classification of COVID-19, 1 case was mild type, 16 cases were ordinary type, and 1 case was severe type. 2. According to imaging examinations: 15 (83%) cases showed unilateral or bilateral pneumonia, 2 (11%) cases had pulmonary infection with pleural effusion, and 1 (6%) case had no abnormal imaging changes. 8 (44%) cases were positive and 10 (56%) cases were negative for nasopharyngeal-swab tests of SARS-CoV-2. 3. Among the 18 newborns, there were 3 (17%) premature infants, 1 (6%) case of mild asphyxia, 5 (28%) cases of bacterial pneumonia, 1 (6%) case of gastrointestinal bleeding, 1 (6%) case of necrotizing enteritis, 2 (11%) cases of hyperbilirubinemia and 1 (6%) case of diarrhea. All the newborns were negative for the first throat swab test of SARS-CoV-2 after birth. 4. Follow-up to Mar 7, 2020, no maternal and neonatal deaths occurred.

CONCLUSIONS

The majority of patients in late term pregnancy with COVID-19 were of ordinary type, and they were less likely to develop into critical pneumonia after early isolation and antiviral treatment. Vertical transmission of SARS-CoV-2 was not detected, but the proportion of neonatal bacterial pneumonia was higher than other neonatal diseases in newborns.

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Authors+Show Affiliations

Zhang L
Department Of Obstetrics and Gynecology, Renmin Hospital Of Wuhan University, Wuhan, 430060, China.
Dong L
Department Of Obstetrics and Gynecology, Renmin Hospital Of Wuhan University, Wuhan, 430060, China.
Ming L
Department Of Reproductive Medicine Center, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Renmin Hospital Of Wuhan University, Wuhan, 430060, China. leimingx@hotmail.com.
Wei M
Department Of Obstetrics and Gynecology, Renmin Hospital Of Wuhan University, Wuhan, 430060, China.
Li J
Department Of Obstetrics and Gynecology, Renmin Hospital Of Wuhan University, Wuhan, 430060, China.
Hu R
Department Of Obstetrics, The Central Hospital of Qianjiang City, Qianjiang, 433199, China.
Yang J
Department Of Reproductive Medicine Center, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Renmin Hospital Of Wuhan University, Wuhan, 430060, China. 13507182023@163.com.

MeSH

AdultBetacoronavirusCOVID-19ChinaCoronavirus InfectionsFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPandemicsPneumonia, ViralPregnancyPregnancy Complications, InfectiousPregnancy OutcomePremature BirthSARS-CoV-2

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32641013

Citation

Zhang, Lu, et al. "Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) Infection During Late Pregnancy: a Report of 18 Patients From Wuhan, China." BMC Pregnancy and Childbirth, vol. 20, no. 1, 2020, p. 394.
Zhang L, Dong L, Ming L, et al. Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China. BMC Pregnancy Childbirth. 2020;20(1):394.
Zhang, L., Dong, L., Ming, L., Wei, M., Li, J., Hu, R., & Yang, J. (2020). Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China. BMC Pregnancy and Childbirth, 20(1), 394. https://doi.org/10.1186/s12884-020-03026-3
Zhang L, et al. Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) Infection During Late Pregnancy: a Report of 18 Patients From Wuhan, China. BMC Pregnancy Childbirth. 2020 Jul 8;20(1):394. PubMed PMID: 32641013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China. AU - Zhang,Lu, AU - Dong,Lan, AU - Ming,Lei, AU - Wei,Min, AU - Li,Jun, AU - Hu,Ruheng, AU - Yang,Jing, Y1 - 2020/07/08/ PY - 2020/03/14/received PY - 2020/05/20/accepted PY - 2020/7/10/entrez PY - 2020/7/10/pubmed PY - 2020/7/23/medline KW - Corona Virus Disease 2019(COVID-19) KW - Neonatal pneumonia KW - Premature KW - Severe Acute Respiratory Syndrome Coronavirus 2(SARS-COV-2) SP - 394 EP - 394 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 20 IS - 1 N2 - BACKGROUND: Compared with Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hope to provide some references for obstetric treatment and management. METHODS: A total of 18 patients with COVID-19 treated at Renmin Hospital of Wuhan University were collected. The epidemiological characteristics, clinical manifestations, laboratory tests, chest CT and pregnancy outcomes were performed for analysis. RESULTS: 1. 18 cases of late pregnancy infected with SARS-CoV-2 pneumonia were delivered at 35 + 5 weeks to 41 weeks. According to the clinical classification of COVID-19, 1 case was mild type, 16 cases were ordinary type, and 1 case was severe type. 2. According to imaging examinations: 15 (83%) cases showed unilateral or bilateral pneumonia, 2 (11%) cases had pulmonary infection with pleural effusion, and 1 (6%) case had no abnormal imaging changes. 8 (44%) cases were positive and 10 (56%) cases were negative for nasopharyngeal-swab tests of SARS-CoV-2. 3. Among the 18 newborns, there were 3 (17%) premature infants, 1 (6%) case of mild asphyxia, 5 (28%) cases of bacterial pneumonia, 1 (6%) case of gastrointestinal bleeding, 1 (6%) case of necrotizing enteritis, 2 (11%) cases of hyperbilirubinemia and 1 (6%) case of diarrhea. All the newborns were negative for the first throat swab test of SARS-CoV-2 after birth. 4. Follow-up to Mar 7, 2020, no maternal and neonatal deaths occurred. CONCLUSIONS: The majority of patients in late term pregnancy with COVID-19 were of ordinary type, and they were less likely to develop into critical pneumonia after early isolation and antiviral treatment. Vertical transmission of SARS-CoV-2 was not detected, but the proportion of neonatal bacterial pneumonia was higher than other neonatal diseases in newborns. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/32641013/Severe_acute_respiratory_syndrome_coronavirus_2_SARS_CoV_2__infection_during_late_pregnancy:_a_report_of_18_patients_from_Wuhan_China_ DB - PRIME DP - Unbound Medicine ER -