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Fluconazole-induced acute generalized exanthematous pustulosis.
Am J Emerg Med. 2021 01; 39:254.e5-254.e7.AJ

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction usually caused by drugs. The annual incidence is one to five cases per million. It is characterized by an acute febrile episode, accompanied by numerous small primarily non-follicular, sterile pustules arising within large areas of edematous erythema. There have been several case reports to date of AGEP following exposure to antifungals. Terbinafine is most commonly implicated in AGEP. We report a case of 7-year-old boy who developed AGEP shortly after commencing oral fluconazole for Tinea capitis. To our knowledge, this is the fourth reported case of AGEP due to fluconazole.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Saliba E
Department of Dermatology, Lebanese American University Medical Center - Rizk Hospital, Beirut, Lebanon. Electronic address: elie.saliba01@lau.edu.
Chrabieh R
Department of Dermatology, Lebanese American University Medical Center - Rizk Hospital, Beirut, Lebanon.
Tannous Z
Department of Dermatology, Lebanese American University Medical Center - Rizk Hospital, Beirut, Lebanon; Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.

MeSH

Acute Generalized Exanthematous PustulosisAntifungal AgentsChildFluconazoleHumansMale

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32641264

Citation

Saliba, Elie, et al. "Fluconazole-induced Acute Generalized Exanthematous Pustulosis." The American Journal of Emergency Medicine, vol. 39, 2021, pp. 254.e5-254.e7.
Saliba E, Chrabieh R, Tannous Z. Fluconazole-induced acute generalized exanthematous pustulosis. Am J Emerg Med. 2021;39:254.e5-254.e7.
Saliba, E., Chrabieh, R., & Tannous, Z. (2021). Fluconazole-induced acute generalized exanthematous pustulosis. The American Journal of Emergency Medicine, 39, e5-e7. https://doi.org/10.1016/j.ajem.2020.06.061
Saliba E, Chrabieh R, Tannous Z. Fluconazole-induced Acute Generalized Exanthematous Pustulosis. Am J Emerg Med. 2021;39:254.e5-254.e7. PubMed PMID: 32641264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluconazole-induced acute generalized exanthematous pustulosis. AU - Saliba,Elie, AU - Chrabieh,Remie, AU - Tannous,Zeina, Y1 - 2020/06/28/ PY - 2020/06/14/received PY - 2020/06/21/accepted PY - 2020/7/10/pubmed PY - 2021/2/9/medline PY - 2020/7/10/entrez KW - Acute generalized exanthematous pustulosis KW - Fluconazole SP - 254.e5 EP - 254.e7 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 39 N2 - Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction usually caused by drugs. The annual incidence is one to five cases per million. It is characterized by an acute febrile episode, accompanied by numerous small primarily non-follicular, sterile pustules arising within large areas of edematous erythema. There have been several case reports to date of AGEP following exposure to antifungals. Terbinafine is most commonly implicated in AGEP. We report a case of 7-year-old boy who developed AGEP shortly after commencing oral fluconazole for Tinea capitis. To our knowledge, this is the fourth reported case of AGEP due to fluconazole. SN - 1532-8171 UR - https://www.unboundmedicine.com/medline/citation/32641264/Fluconazole_induced_acute_generalized_exanthematous_pustulosis_ DB - PRIME DP - Unbound Medicine ER -