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[A case of neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy successfully treated with Cyclosporine A].
Rinsho Shinkeigaku. 2020 Jul 07 [Online ahead of print]RS

Abstract

A 41-year-old man noticed numbness of the fingers and toes, and gradually developed limb weakness and sensory impairment. The patient was diagnosed with typical chronic inflammatory demyelinating polyradiculoneuropathy. Over the course of clinical diagnosis, the limb and trunk ataxia, and finger tremor became prominent, and the presence anti-neurofascin-155 antibody was examined and confirmed positive. The effects of corticosteroids, intravenous immunoglobulin, and plasma apheresis were limited, and the disease progressed slowly and noticeably. Therefore, cyclosporine was introduced as treatment, and the patient's weakness and ataxia significantly improved. Rituximab treatment is expected to be effective in patients with the same antibody and immunosuppressant treatment may be useful in intractable cases.

Authors+Show Affiliations

Department of Neurology, Nihonkai General Hospital.Department of Neurology, Kyushu University Graduate School of Medicine.Department of Neurology, Kindai University Faculty of Medicine.Department of Neurology, Kyushu University Graduate School of Medicine.Department of Neurology, Kindai University Faculty of Medicine.Department of Neurology, Nihonkai General Hospital.

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

32641627

Citation

Sato, Daisuke, et al. "[A Case of Neurofascin-155 Antibody-positive Chronic Inflammatory Demyelinating Polyradiculoneuropathy Successfully Treated With Cyclosporine A]." Rinsho Shinkeigaku = Clinical Neurology, 2020.
Sato D, Ogata H, Kuwahara M, et al. [A case of neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy successfully treated with Cyclosporine A]. Rinsho Shinkeigaku. 2020.
Sato, D., Ogata, H., Kuwahara, M., Kira, J., Kusunoki, S., & Suzuki, Y. (2020). [A case of neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy successfully treated with Cyclosporine A]. Rinsho Shinkeigaku = Clinical Neurology. https://doi.org/10.5692/clinicalneurol.60.cn-001403
Sato D, et al. [A Case of Neurofascin-155 Antibody-positive Chronic Inflammatory Demyelinating Polyradiculoneuropathy Successfully Treated With Cyclosporine A]. Rinsho Shinkeigaku. 2020 Jul 7; PubMed PMID: 32641627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy successfully treated with Cyclosporine A]. AU - Sato,Daisuke, AU - Ogata,Hidenori, AU - Kuwahara,Motoi, AU - Kira,Junichi, AU - Kusunoki,Susumu, AU - Suzuki,Yoshihiro, Y1 - 2020/07/07/ PY - 2020/7/10/entrez KW - Cyclosporine A KW - chronic inflammatory demyelinating polyradiculoneuropathy KW - first line therapy KW - intravenous immunoglobulin KW - neurofascin-155 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku N2 - A 41-year-old man noticed numbness of the fingers and toes, and gradually developed limb weakness and sensory impairment. The patient was diagnosed with typical chronic inflammatory demyelinating polyradiculoneuropathy. Over the course of clinical diagnosis, the limb and trunk ataxia, and finger tremor became prominent, and the presence anti-neurofascin-155 antibody was examined and confirmed positive. The effects of corticosteroids, intravenous immunoglobulin, and plasma apheresis were limited, and the disease progressed slowly and noticeably. Therefore, cyclosporine was introduced as treatment, and the patient's weakness and ataxia significantly improved. Rituximab treatment is expected to be effective in patients with the same antibody and immunosuppressant treatment may be useful in intractable cases. SN - 1882-0654 UR - https://www.unboundmedicine.com/medline/citation/32641627/[A_case_of_neurofascin-155_antibody-positive_chronic_inflammatory_demyelinating_polyradiculoneuropathy_successfully_treated_with_Cyclosporine_A] L2 - https://dx.doi.org/10.5692/clinicalneurol.60.cn-001403 DB - PRIME DP - Unbound Medicine ER -
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