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[A case of paraneoplastic myelopathy associated with anti-CV2/CRMP5 antibodies with small-cell lung cancer].
Rinsho Shinkeigaku. 2020 Jul 07 [Online ahead of print]RS

Abstract

A 66-year-old woman with small-cell lung cancer and cancer-associated retinopathy with anti-recoverin antibodies presented with subacute paraplegia associated with recurrence of lung cancer. Although a spinal cord MRI did not show any visible lesion, the neurological symptoms and cerebrospinal fluid findings indicated myelitis. Anti-CV2/CRMP5 antibodies were also positive and the patient was diagnosed with paraneoplastic myelopathy. After medication with prednisolone, her neurological symptoms improved and she survived over three years without recurrence of neurological symptoms. In general, paraneoplastic myelopathy is refractory against immunotherapy but in this case, immunotherapy was successful and resulted in long-term survival. We recommend examining anti-neuronal antibodies and choose and continue the appropriate immunotherapy.

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.Obihiro Kosei Hospital, Department of Neurology.Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University. Hakodate Central General Hospital, Department of Neurology.

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

32641628

Citation

Sato, Chika, et al. "[A Case of Paraneoplastic Myelopathy Associated With anti-CV2/CRMP5 Antibodies With Small-cell Lung Cancer]." Rinsho Shinkeigaku = Clinical Neurology, 2020.
Sato C, Kano T, Yabe I, et al. [A case of paraneoplastic myelopathy associated with anti-CV2/CRMP5 antibodies with small-cell lung cancer]. Rinsho Shinkeigaku. 2020.
Sato, C., Kano, T., Yabe, I., & Sasaki, H. (2020). [A case of paraneoplastic myelopathy associated with anti-CV2/CRMP5 antibodies with small-cell lung cancer]. Rinsho Shinkeigaku = Clinical Neurology. https://doi.org/10.5692/clinicalneurol.60.cn-001432
Sato C, et al. [A Case of Paraneoplastic Myelopathy Associated With anti-CV2/CRMP5 Antibodies With Small-cell Lung Cancer]. Rinsho Shinkeigaku. 2020 Jul 7; PubMed PMID: 32641628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of paraneoplastic myelopathy associated with anti-CV2/CRMP5 antibodies with small-cell lung cancer]. AU - Sato,Chika, AU - Kano,Takahiro, AU - Yabe,Ichiro, AU - Sasaki,Hidenao, Y1 - 2020/07/07/ PY - 2020/7/10/entrez KW - anti CV2/CRMP5 antibody KW - cancer associated retinopathy with anti-Recoverin antibody KW - myelopathy KW - paraneoplastic neurological syndrome JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku N2 - A 66-year-old woman with small-cell lung cancer and cancer-associated retinopathy with anti-recoverin antibodies presented with subacute paraplegia associated with recurrence of lung cancer. Although a spinal cord MRI did not show any visible lesion, the neurological symptoms and cerebrospinal fluid findings indicated myelitis. Anti-CV2/CRMP5 antibodies were also positive and the patient was diagnosed with paraneoplastic myelopathy. After medication with prednisolone, her neurological symptoms improved and she survived over three years without recurrence of neurological symptoms. In general, paraneoplastic myelopathy is refractory against immunotherapy but in this case, immunotherapy was successful and resulted in long-term survival. We recommend examining anti-neuronal antibodies and choose and continue the appropriate immunotherapy. SN - 1882-0654 UR - https://www.unboundmedicine.com/medline/citation/32641628/[A_case_of_paraneoplastic_myelopathy_associated_with_anti-CV2/CRMP5_antibodies_with_small-cell_lung_cancer] L2 - https://dx.doi.org/10.5692/clinicalneurol.60.cn-001432 DB - PRIME DP - Unbound Medicine ER -
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