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SARS-CoV-2 is transmitted via contact and via the air between ferrets.
Nat Commun. 2020 07 08; 11(1):3496.NC

Abstract

SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently via direct contact and via the air (via respiratory droplets and/or aerosols) between ferrets, 1 to 3 days and 3 to 7 days after exposure respectively. The pattern of virus shedding in the direct contact and indirect recipient ferrets is similar to that of the inoculated ferrets and infectious virus is isolated from all positive animals, showing that ferrets are productively infected via either route. This study provides experimental evidence of robust transmission of SARS-CoV-2 via the air, supporting the implementation of community-level social distancing measures currently applied in many countries in the world and informing decisions on infection control measures in healthcare settings.

Authors+Show Affiliations

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands. s.herfst@erasmusmc.nl.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32641684

Citation

Richard, Mathilde, et al. "SARS-CoV-2 Is Transmitted Via Contact and Via the Air Between Ferrets." Nature Communications, vol. 11, no. 1, 2020, p. 3496.
Richard M, Kok A, de Meulder D, et al. SARS-CoV-2 is transmitted via contact and via the air between ferrets. Nat Commun. 2020;11(1):3496.
Richard, M., Kok, A., de Meulder, D., Bestebroer, T. M., Lamers, M. M., Okba, N. M. A., Fentener van Vlissingen, M., Rockx, B., Haagmans, B. L., Koopmans, M. P. G., Fouchier, R. A. M., & Herfst, S. (2020). SARS-CoV-2 is transmitted via contact and via the air between ferrets. Nature Communications, 11(1), 3496. https://doi.org/10.1038/s41467-020-17367-2
Richard M, et al. SARS-CoV-2 Is Transmitted Via Contact and Via the Air Between Ferrets. Nat Commun. 2020 07 8;11(1):3496. PubMed PMID: 32641684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 is transmitted via contact and via the air between ferrets. AU - Richard,Mathilde, AU - Kok,Adinda, AU - de Meulder,Dennis, AU - Bestebroer,Theo M, AU - Lamers,Mart M, AU - Okba,Nisreen M A, AU - Fentener van Vlissingen,Martje, AU - Rockx,Barry, AU - Haagmans,Bart L, AU - Koopmans,Marion P G, AU - Fouchier,Ron A M, AU - Herfst,Sander, Y1 - 2020/07/08/ PY - 2020/04/15/received PY - 2020/06/25/accepted PY - 2020/7/10/entrez PY - 2020/7/10/pubmed PY - 2020/7/18/medline SP - 3496 EP - 3496 JF - Nature communications JO - Nat Commun VL - 11 IS - 1 N2 - SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently via direct contact and via the air (via respiratory droplets and/or aerosols) between ferrets, 1 to 3 days and 3 to 7 days after exposure respectively. The pattern of virus shedding in the direct contact and indirect recipient ferrets is similar to that of the inoculated ferrets and infectious virus is isolated from all positive animals, showing that ferrets are productively infected via either route. This study provides experimental evidence of robust transmission of SARS-CoV-2 via the air, supporting the implementation of community-level social distancing measures currently applied in many countries in the world and informing decisions on infection control measures in healthcare settings. SN - 2041-1723 UR - https://www.unboundmedicine.com/medline/citation/32641684/SARS_CoV_2_is_transmitted_via_contact_and_via_the_air_between_ferrets_ L2 - http://dx.doi.org/10.1038/s41467-020-17367-2 DB - PRIME DP - Unbound Medicine ER -