Tags

Type your tag names separated by a space and hit enter

A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP).
Iran J Pharm Res. 2019 Summer; 18(3):1595-1601.IJ

Abstract

Recent studies suggest a relationship between zinc deficiency and inflammation. In the present study, we studied the effect of oral zinc supplementation on clinical improvement of chronic rhinosinusitis with nasal polyposis. In this single-blind randomized controlled trial, 44 patients with chronic rhinosinusitis with polyposis referring to ENT clinic of the Loghman Hakim hospital during 2013-2014 were randomly allocated in two groups. The treatment group (n = 28) was treated with a four-drug fixed-dose regimen (FD_FDR) consisting of oral dexamethasone (0.02 mg/kg), fluticasone nasal spray, fexophenadine 60 mg daily, montelukast 10 mg daily plus 220mg zinc sulfate capsules containing 55 mg elemental zinc, b.d., and the control group (n = 16) received the FD_FDR without supplemental zinc, for six weeks. After sixth week, two groups were compared regarding clinical outcomes based on theSNOT20 (Sinonasal outcome test) questionnaire, the general health questionnaire (SF12), the Lund-Mackay, and the Lund-Kennedy scoring systems. In the treatment group, serum zinc levels were significantly increased compared to those at the baseline (1.33 fold-increase; p = 0.0002). Within groups analysis revealed a significant reduction (p < 0.01) in LM and LK in both treatment (55% LM; 50% LK) and control groups (45% LM; 53% LK). Incontrast, between groups analysis revealed no significant differences in the LM and LK. The treatment group showed a mild superiority in general health improvement compared to that of the control group. Add-on therapy with supplemental zinc sulfate was not associated with significant improvement in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). The advantage of zinc supplementation on the general health improvement of the patients with CRSwNP requires further assessments.

Authors+Show Affiliations

Department of Otolaryngology, Head and Neck Surgery, Loghman Hakim Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hearing Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Otolaryngology, Head and Neck Surgery, Loghman Hakim Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Otolaryngology, Head and Neck Surgery, Loghman Hakim Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32641966

Citation

Akbari Dilmaghani, Nader, et al. "A Randomized Clinical Trial of Elemental Zinc Add-on Therapy On Clinical Outcomes of Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)." Iranian Journal of Pharmaceutical Research : IJPR, vol. 18, no. 3, 2019, pp. 1595-1601.
Akbari Dilmaghani N, Alani N, Fazeli S. A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP). Iran J Pharm Res. 2019;18(3):1595-1601.
Akbari Dilmaghani, N., Alani, N., & Fazeli, S. (2019). A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP). Iranian Journal of Pharmaceutical Research : IJPR, 18(3), 1595-1601. https://doi.org/10.22037/ijpr.2019.1100767
Akbari Dilmaghani N, Alani N, Fazeli S. A Randomized Clinical Trial of Elemental Zinc Add-on Therapy On Clinical Outcomes of Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP). Iran J Pharm Res. 2019;18(3):1595-1601. PubMed PMID: 32641966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP). AU - Akbari Dilmaghani,Nader, AU - Alani,Nadereh, AU - Fazeli,Sepideh, PY - 2020/7/10/entrez PY - 2020/7/10/pubmed PY - 2020/7/10/medline KW - Chronic rhinosinusitis KW - Lund-Kennedy score KW - Lund-Mackay score KW - Nasal polyposis KW - Zinc SP - 1595 EP - 1601 JF - Iranian journal of pharmaceutical research : IJPR JO - Iran J Pharm Res VL - 18 IS - 3 N2 - Recent studies suggest a relationship between zinc deficiency and inflammation. In the present study, we studied the effect of oral zinc supplementation on clinical improvement of chronic rhinosinusitis with nasal polyposis. In this single-blind randomized controlled trial, 44 patients with chronic rhinosinusitis with polyposis referring to ENT clinic of the Loghman Hakim hospital during 2013-2014 were randomly allocated in two groups. The treatment group (n = 28) was treated with a four-drug fixed-dose regimen (FD_FDR) consisting of oral dexamethasone (0.02 mg/kg), fluticasone nasal spray, fexophenadine 60 mg daily, montelukast 10 mg daily plus 220mg zinc sulfate capsules containing 55 mg elemental zinc, b.d., and the control group (n = 16) received the FD_FDR without supplemental zinc, for six weeks. After sixth week, two groups were compared regarding clinical outcomes based on theSNOT20 (Sinonasal outcome test) questionnaire, the general health questionnaire (SF12), the Lund-Mackay, and the Lund-Kennedy scoring systems. In the treatment group, serum zinc levels were significantly increased compared to those at the baseline (1.33 fold-increase; p = 0.0002). Within groups analysis revealed a significant reduction (p < 0.01) in LM and LK in both treatment (55% LM; 50% LK) and control groups (45% LM; 53% LK). Incontrast, between groups analysis revealed no significant differences in the LM and LK. The treatment group showed a mild superiority in general health improvement compared to that of the control group. Add-on therapy with supplemental zinc sulfate was not associated with significant improvement in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). The advantage of zinc supplementation on the general health improvement of the patients with CRSwNP requires further assessments. SN - 1735-0328 UR - https://www.unboundmedicine.com/medline/citation/32641966/A_Randomized_Clinical_Trial_of_Elemental_Zinc_Add-on_Therapy_on_Clinical_Outcomes_of_Patients_with_Chronic_Rhinosinusitis_with_Nasal_Polyposis_(CRSwNP) L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32641966/ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.