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Photobiomodulation for mucosal repair in patients submitted to dental extraction after head and neck radiation therapy: a double-blind randomized pilot study.
Support Care Cancer. 2020 Jul 09 [Online ahead of print]SC

Abstract

OBJECTIVE

The aim of this study was to evaluate the efficacy of photobiomodulation therapy (PBMT) on the mucosal healing of patients submitted to simple dental extractions after head and neck radiation therapy (HNRT).

METHODS

Forty surgical procedures were randomly assigned into two groups: G1: dental extraction + PBMT (n = 19) and G2: dental extraction + sham-PBMT (n = 21). All patients received antibiotic therapy and the surgical alveolotomy to promote primary closure of the surgical site. Group 1 was submitted to PMBT according to the following parameters: 808 nm, 40 mW, 100 J/cm2, 70 s, 2.8 J/point, 14 J/session, and area of 0.028cm2. The primary outcome was complete mucosal lining at 14 days, and the secondary outcomes were the presence of infection, postoperative pain, and analgesics intake at 7 days. The patients were evaluated every 7 days until 28 days.

RESULTS

Alveolar mucosal lining was faster in G1, and at 14 postoperative days, 94.7% patients evolved with complete alveolar mucosal lining compared to no patient from G2 (p < 0.001). Patients from G1 reported postoperative pain less frequently (G1 = 4, 21.1% × G2 = 14, 66.7%, p = 0.005), and also reported lower intake of analgesic pills at D7 (21.1% × 66.7%, p = 0.005%). PBMT had a significant positive impact on both postoperative pain (NNT = 2.192, CI95% = 1.372-5.445) and mucosal healing (NNT = 1.056, CI95% = 0.954-1.181).

CONCLUSIONS

This preliminary study strongly supports the use of PMBT to promote surgical alveolar mucosal lining in a shorter time and with less postoperative pain.

Authors+Show Affiliations

Oral Medicine Unit, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CDU, Recife, PE, 50670-901, Brazil. Graduate Program in Dentistry, Universidade Federal de Pernambuco, Recife, Brazil.Graduate Program in Dentistry, Universidade Federal de Pernambuco, Recife, Brazil.Oral Medicine Unit, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CDU, Recife, PE, 50670-901, Brazil.Oral Medicine Unit, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CDU, Recife, PE, 50670-901, Brazil.Oral Medicine Unit, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CDU, Recife, PE, 50670-901, Brazil. Graduate Program in Dentistry, Universidade Federal de Pernambuco, Recife, Brazil.Dental Oncology Unit, Hospital do Câncer de Pernambuco, Recife, Brazil.Oral Medicine Unit, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CDU, Recife, PE, 50670-901, Brazil. luiz.mgueiros@ufpe.br. Graduate Program in Dentistry, Universidade Federal de Pernambuco, Recife, Brazil. luiz.mgueiros@ufpe.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32642953

Citation

da Silva, Thyago Morais Vicente, et al. "Photobiomodulation for Mucosal Repair in Patients Submitted to Dental Extraction After Head and Neck Radiation Therapy: a Double-blind Randomized Pilot Study." Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 2020.
da Silva TMV, Melo TS, de Alencar RC, et al. Photobiomodulation for mucosal repair in patients submitted to dental extraction after head and neck radiation therapy: a double-blind randomized pilot study. Support Care Cancer. 2020.
da Silva, T. M. V., Melo, T. S., de Alencar, R. C., Pereira, J. R. D., Leão, J. C., Silva, I. H. M., & Gueiros, L. A. (2020). Photobiomodulation for mucosal repair in patients submitted to dental extraction after head and neck radiation therapy: a double-blind randomized pilot study. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. https://doi.org/10.1007/s00520-020-05608-5
da Silva TMV, et al. Photobiomodulation for Mucosal Repair in Patients Submitted to Dental Extraction After Head and Neck Radiation Therapy: a Double-blind Randomized Pilot Study. Support Care Cancer. 2020 Jul 9; PubMed PMID: 32642953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photobiomodulation for mucosal repair in patients submitted to dental extraction after head and neck radiation therapy: a double-blind randomized pilot study. AU - da Silva,Thyago Morais Vicente, AU - Melo,Thayanara Silva, AU - de Alencar,Romulo Cesar, AU - Pereira,José Ricardo Dias, AU - Leão,Jair Carneiro, AU - Silva,Igor Henrique Morais, AU - Gueiros,Luiz Alcino, Y1 - 2020/07/09/ PY - 2020/04/18/received PY - 2020/06/26/accepted PY - 2020/7/10/entrez KW - Dental extraction KW - Osteoradionecrosis KW - Photobiomodulation therapy KW - Radiotherapy JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JO - Support Care Cancer N2 - OBJECTIVE: The aim of this study was to evaluate the efficacy of photobiomodulation therapy (PBMT) on the mucosal healing of patients submitted to simple dental extractions after head and neck radiation therapy (HNRT). METHODS: Forty surgical procedures were randomly assigned into two groups: G1: dental extraction + PBMT (n = 19) and G2: dental extraction + sham-PBMT (n = 21). All patients received antibiotic therapy and the surgical alveolotomy to promote primary closure of the surgical site. Group 1 was submitted to PMBT according to the following parameters: 808 nm, 40 mW, 100 J/cm2, 70 s, 2.8 J/point, 14 J/session, and area of 0.028cm2. The primary outcome was complete mucosal lining at 14 days, and the secondary outcomes were the presence of infection, postoperative pain, and analgesics intake at 7 days. The patients were evaluated every 7 days until 28 days. RESULTS: Alveolar mucosal lining was faster in G1, and at 14 postoperative days, 94.7% patients evolved with complete alveolar mucosal lining compared to no patient from G2 (p < 0.001). Patients from G1 reported postoperative pain less frequently (G1 = 4, 21.1% × G2 = 14, 66.7%, p = 0.005), and also reported lower intake of analgesic pills at D7 (21.1% × 66.7%, p = 0.005%). PBMT had a significant positive impact on both postoperative pain (NNT = 2.192, CI95% = 1.372-5.445) and mucosal healing (NNT = 1.056, CI95% = 0.954-1.181). CONCLUSIONS: This preliminary study strongly supports the use of PMBT to promote surgical alveolar mucosal lining in a shorter time and with less postoperative pain. SN - 1433-7339 UR - https://www.unboundmedicine.com/medline/citation/32642953/Photobiomodulation_for_mucosal_repair_in_patients_submitted_to_dental_extraction_after_head_and_neck_radiation_therapy:_a_double-blind_randomized_pilot_study L2 - https://dx.doi.org/10.1007/s00520-020-05608-5 DB - PRIME DP - Unbound Medicine ER -
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