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Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study.
Mov Disord. 2020 10; 35(10):1765-1773.MD

Abstract

BACKGROUND

Despite experimental evidence implicating oxidative stress in the pathogenesis of PD, epidemiological studies have provided inconsistent associations between dietary antioxidants and risk of developing PD. Furthermore, no study has been done in any Asian population.

OBJECTIVES

We examined the associations for intake levels of dietary carotenoids (α-carotene, β-carotene, lycopene, β-cryptoxanthin, and lutein) and vitamins (vitamin A, C and E) and the risk of developing PD.

METHODS

We used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63,257 men and women aged 45 to 74 years during enrollment in 1993-1998. Antioxidant intake was derived from a validated semiquantitative food frequency questionnaire. Incident cases were identified through follow-up interviews, hospital records, or PD registries through 31 July 2018. Hazard ratios and corresponding 95% confidence intervals were derived from multivariable Cox proportional hazard regression models with adjustment for other lifestyle and dietary factors.

RESULTS

During an average 19.4 years of follow-up, 544 incident PD cases were identified. No association was found for dietary carotenoids, individually or summed. Hazard ratio comparing highest to lowest quartile for total carotenoids was 0.98 (95% confidence interval: 0.76-1.28; Ptrend = 0.83). There were also no clear dose-dependent associations of dietary vitamins A, C, and E with risk of developing PD (all Ptrend ≥ 0.10). Sensitive analyses with lag time and excluding supplement use did not materially alter results.

CONCLUSIONS

Intake of dietary antioxidants, such as carotenoids and vitamins, was not associated with the risk of developing PD in Singaporean Chinese. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Health Services and Systems Research, Duke-NUS Medical School, Singapore.Department of Neurology, National Neuroscience Institute, Singapore.Department of Neurology, National Neuroscience Institute, Singapore.Health Services and Systems Research, Duke-NUS Medical School, Singapore.Department of Neurology, National Neuroscience Institute, Singapore.Health Services and Systems Research, Duke-NUS Medical School, Singapore. Department of Neurology, National Neuroscience Institute, Singapore.Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Health Services and Systems Research, Duke-NUS Medical School, Singapore. Saw Swee Hock School of Public Health, National University of Singapore.Health Services and Systems Research, Duke-NUS Medical School, Singapore. Department of Neurology, National Neuroscience Institute, Singapore.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32643256

Citation

Ying, Ariel Fangting, et al. "Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 35, no. 10, 2020, pp. 1765-1773.
Ying AF, Khan S, Wu Y, et al. Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study. Mov Disord. 2020;35(10):1765-1773.
Ying, A. F., Khan, S., Wu, Y., Jin, A., Wong, A. S. Y., Tan, E. K., Yuan, J. M., Koh, W. P., & Tan, L. C. S. (2020). Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study. Movement Disorders : Official Journal of the Movement Disorder Society, 35(10), 1765-1773. https://doi.org/10.1002/mds.28173
Ying AF, et al. Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study. Mov Disord. 2020;35(10):1765-1773. PubMed PMID: 32643256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study. AU - Ying,Ariel Fangting, AU - Khan,Shazma, AU - Wu,Ying, AU - Jin,Aizhen, AU - Wong,Aidan S Y, AU - Tan,Eng-King, AU - Yuan,Jian-Min, AU - Koh,Woon-Puay, AU - Tan,Louis C S, Y1 - 2020/07/09/ PY - 2020/02/27/received PY - 2020/04/24/revised PY - 2020/05/26/accepted PY - 2020/7/10/pubmed PY - 2021/4/28/medline PY - 2020/7/10/entrez KW - Parkinson's disease KW - antioxidants KW - diet KW - oxidative stress KW - prospective study SP - 1765 EP - 1773 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 35 IS - 10 N2 - BACKGROUND: Despite experimental evidence implicating oxidative stress in the pathogenesis of PD, epidemiological studies have provided inconsistent associations between dietary antioxidants and risk of developing PD. Furthermore, no study has been done in any Asian population. OBJECTIVES: We examined the associations for intake levels of dietary carotenoids (α-carotene, β-carotene, lycopene, β-cryptoxanthin, and lutein) and vitamins (vitamin A, C and E) and the risk of developing PD. METHODS: We used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63,257 men and women aged 45 to 74 years during enrollment in 1993-1998. Antioxidant intake was derived from a validated semiquantitative food frequency questionnaire. Incident cases were identified through follow-up interviews, hospital records, or PD registries through 31 July 2018. Hazard ratios and corresponding 95% confidence intervals were derived from multivariable Cox proportional hazard regression models with adjustment for other lifestyle and dietary factors. RESULTS: During an average 19.4 years of follow-up, 544 incident PD cases were identified. No association was found for dietary carotenoids, individually or summed. Hazard ratio comparing highest to lowest quartile for total carotenoids was 0.98 (95% confidence interval: 0.76-1.28; Ptrend = 0.83). There were also no clear dose-dependent associations of dietary vitamins A, C, and E with risk of developing PD (all Ptrend ≥ 0.10). Sensitive analyses with lag time and excluding supplement use did not materially alter results. CONCLUSIONS: Intake of dietary antioxidants, such as carotenoids and vitamins, was not associated with the risk of developing PD in Singaporean Chinese. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/32643256/Dietary_Antioxidants_and_Risk_of_Parkinson's_Disease_in_the_Singapore_Chinese_Health_Study_ L2 - https://doi.org/10.1002/mds.28173 DB - PRIME DP - Unbound Medicine ER -