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Biomarkers in vesicoureteral reflux: an overview.
Biomark Med. 2020 Jun; 14(8):683-696.BM

Abstract

Aim:

This article aimed to review the role of cytokines, chemokines, growth factors and cellular adhesion molecules as biomarkers for vesicoureteral reflux (VUR) and reflux nephropathy (RN).

Methods:

We reviewed articles from 1979 onward by searching PubMed and Scopus utilizing the combination of words: 'VUR' or 'RN' and each one of the biomarkers.

Results:

Genetic, inflammatory, fibrogenic, environmental and epigenetic factors responsible for renal scarring need to be better understood. TGF-β, IL-10, IL-6, IL-8 and TNF seem to exert a role in VUR particularly in RN based on the current literature. Serum levels of procalcitonin have been also associated with high-grade VUR and RN. These molecules should be more intensively evaluated as potential biomarkers for renal scarring in VUR.

Conclusion:

Further studies are necessary to define which molecules will really be of utility in clinical decisions and as therapeutic targets for VUR and RN.

Authors+Show Affiliations

Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil. Pediatric Nephrology Unit, Hospital das Clínicas, UFMG, Belo Horizonte, MG, Brazil.Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil.Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil.Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil.Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil.Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil. Pediatric Nephrology Unit, Hospital das Clínicas, UFMG, Belo Horizonte, MG, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32643393

Citation

Valério, Flávia C., et al. "Biomarkers in Vesicoureteral Reflux: an Overview." Biomarkers in Medicine, vol. 14, no. 8, 2020, pp. 683-696.
Valério FC, Lemos RD, de C Reis AL, et al. Biomarkers in vesicoureteral reflux: an overview. Biomark Med. 2020;14(8):683-696.
Valério, F. C., Lemos, R. D., de C Reis, A. L., Pimenta, L. P., Vieira, É. L., & Silva, A. C. E. (2020). Biomarkers in vesicoureteral reflux: an overview. Biomarkers in Medicine, 14(8), 683-696. https://doi.org/10.2217/bmm-2019-0378
Valério FC, et al. Biomarkers in Vesicoureteral Reflux: an Overview. Biomark Med. 2020;14(8):683-696. PubMed PMID: 32643393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomarkers in vesicoureteral reflux: an overview. AU - Valério,Flávia C, AU - Lemos,Renata D, AU - de C Reis,Ana L, AU - Pimenta,Letícia P, AU - Vieira,Érica Lm, AU - Silva,Ana Cs E, Y1 - 2020/07/09/ PY - 2020/7/10/pubmed PY - 2020/7/10/medline PY - 2020/7/10/entrez KW - adhesion molecules procalcitonin KW - biomarkers KW - chemokines KW - cytokines KW - growth factors KW - inflammation KW - reflux nephropathy KW - vesicoureteral reflux SP - 683 EP - 696 JF - Biomarkers in medicine JO - Biomark Med VL - 14 IS - 8 N2 - Aim: This article aimed to review the role of cytokines, chemokines, growth factors and cellular adhesion molecules as biomarkers for vesicoureteral reflux (VUR) and reflux nephropathy (RN). Methods: We reviewed articles from 1979 onward by searching PubMed and Scopus utilizing the combination of words: 'VUR' or 'RN' and each one of the biomarkers. Results: Genetic, inflammatory, fibrogenic, environmental and epigenetic factors responsible for renal scarring need to be better understood. TGF-β, IL-10, IL-6, IL-8 and TNF seem to exert a role in VUR particularly in RN based on the current literature. Serum levels of procalcitonin have been also associated with high-grade VUR and RN. These molecules should be more intensively evaluated as potential biomarkers for renal scarring in VUR. Conclusion: Further studies are necessary to define which molecules will really be of utility in clinical decisions and as therapeutic targets for VUR and RN. SN - 1752-0371 UR - https://www.unboundmedicine.com/medline/citation/32643393/Biomarkers_in_vesicoureteral_reflux:_an_overview L2 - https://www.futuremedicine.com/doi/10.2217/bmm-2019-0378?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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