Tags

Type your tag names separated by a space and hit enter

Outcomes of autologous non-cultured melanocyte keratinocyte transplantation in vitiligo and nevus depigmentosus.
J Dermatolog Treat. 2020 Jul 20 [Online ahead of print]JD

Abstract

BACKGROUND

Melanocyte-keratinocyte transplantation procedure (MKTP) is an effective surgical technique for restoring skin pigmentation in all types of vitiligo and leukoderma patients who are unresponsive to medical and/or phototherapy treatment. Data specific to the outcomes of MKTP among Thai vitiligo and nevus depigmentosus patients are currently scarce.

OBJECTIVES

To evaluate the efficacy and safety of MKTP in patients with vitiligo or nevus depigmentosus at the short-term (≤6 months) and long-term (≥12 months) follow-up.

MATERIALS AND METHODS

A retrospective review of the medical records of vitiligo or nevus depigmentosus patients who underwent MKTP at the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during 2016 to 2019 was conducted. Repigmentation outcomes were evaluated by Vitiligo Area Scoring Index (VASI).

RESULTS

Twenty-five patients had 27 MKTP surgeries on 32 anatomically-based lesions. The mean age was 32.4 years, the mean age at onset was 25.5 years, and 19 patients were male. Segmental vitiligo, non-segmental vitiligo, and nevus depigmentosus had significantly improved VASI scores at the short-term follow-up (-74.2% ± 23.2%, -100%, and -62.5% ± 17.6%, respectively) and the long-term follow-up (-81% ± 27.7%, -95.0% ± 7.0%, and -83.3% ± 14.4%, respectively).

CONCLUSION

MKTP is a safe and effective method for treating refractory vitiligo and nevus depigmentosus in Thai patients.

Authors+Show Affiliations

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32643482

Citation

Sritanyarat, Thanyanan, et al. "Outcomes of Autologous Non-cultured Melanocyte Keratinocyte Transplantation in Vitiligo and Nevus Depigmentosus." The Journal of Dermatological Treatment, 2020, pp. 1-6.
Sritanyarat T, Wongpraparut C, Jansuwan N, et al. Outcomes of autologous non-cultured melanocyte keratinocyte transplantation in vitiligo and nevus depigmentosus. J Dermatolog Treat. 2020.
Sritanyarat, T., Wongpraparut, C., Jansuwan, N., Yothachai, P., Nuntawisuttiwong, N., & Silpa-Archa, N. (2020). Outcomes of autologous non-cultured melanocyte keratinocyte transplantation in vitiligo and nevus depigmentosus. The Journal of Dermatological Treatment, 1-6. https://doi.org/10.1080/09546634.2020.1793885
Sritanyarat T, et al. Outcomes of Autologous Non-cultured Melanocyte Keratinocyte Transplantation in Vitiligo and Nevus Depigmentosus. J Dermatolog Treat. 2020 Jul 20;1-6. PubMed PMID: 32643482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes of autologous non-cultured melanocyte keratinocyte transplantation in vitiligo and nevus depigmentosus. AU - Sritanyarat,Thanyanan, AU - Wongpraparut,Chanisada, AU - Jansuwan,Natchaya, AU - Yothachai,Punyanut, AU - Nuntawisuttiwong,Nuttaporn, AU - Silpa-Archa,Narumol, Y1 - 2020/07/20/ PY - 2020/7/10/pubmed PY - 2020/7/10/medline PY - 2020/7/10/entrez KW - Autologous transplantation KW - VASI KW - keratinocyte KW - melanocyte KW - nevus depigmentosus KW - vitiligo SP - 1 EP - 6 JF - The Journal of dermatological treatment JO - J Dermatolog Treat N2 - BACKGROUND: Melanocyte-keratinocyte transplantation procedure (MKTP) is an effective surgical technique for restoring skin pigmentation in all types of vitiligo and leukoderma patients who are unresponsive to medical and/or phototherapy treatment. Data specific to the outcomes of MKTP among Thai vitiligo and nevus depigmentosus patients are currently scarce. OBJECTIVES: To evaluate the efficacy and safety of MKTP in patients with vitiligo or nevus depigmentosus at the short-term (≤6 months) and long-term (≥12 months) follow-up. MATERIALS AND METHODS: A retrospective review of the medical records of vitiligo or nevus depigmentosus patients who underwent MKTP at the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during 2016 to 2019 was conducted. Repigmentation outcomes were evaluated by Vitiligo Area Scoring Index (VASI). RESULTS: Twenty-five patients had 27 MKTP surgeries on 32 anatomically-based lesions. The mean age was 32.4 years, the mean age at onset was 25.5 years, and 19 patients were male. Segmental vitiligo, non-segmental vitiligo, and nevus depigmentosus had significantly improved VASI scores at the short-term follow-up (-74.2% ± 23.2%, -100%, and -62.5% ± 17.6%, respectively) and the long-term follow-up (-81% ± 27.7%, -95.0% ± 7.0%, and -83.3% ± 14.4%, respectively). CONCLUSION: MKTP is a safe and effective method for treating refractory vitiligo and nevus depigmentosus in Thai patients. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/32643482/Outcomes_of_autologous_non-cultured_melanocyte_keratinocyte_transplantation_in_vitiligo_and_nevus_depigmentosus L2 - http://www.tandfonline.com/doi/full/10.1080/09546634.2020.1793885 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.