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Nevus cell aggregates massively occupying parenchyma of an external iliac lymph node: a case report and review of the literature.
J Cutan Pathol. 2020 Jul 09 [Online ahead of print]JC

Abstract

We report a case of nevus cell aggregates (NCAs) in an external iliac lymph node from a patient with a compound congenital nevus in the corresponding drainage skin. Melanocytes in parenchyma were in band, nest-like or nodular fashion, and partly continuous with those in capsule and trabeculae. The largest nodule in parenchyma measured 6.5 mm. Melanocytes mostly exhibited benign appearance identical to cutaneous nevus. A few regions abundant in cells displayed atypical features, including increased nucleo-cytoplasmic ratio, small nucleoli, and occasional mitotic figures. Immunohistochemistry showed that melanocytes stained positive for p16, but negative for HMB-45 and nestin. Ki-67 labeling was less than 1% and reticulin mainly surrounded individual melanocytes. Besides, Vysis melanoma Fluorescence in situ hybridization (FISH) plus another 2 probes targeting 9p21(CDKN2A) and 8q24(MYC) showed totally negative. The patient is alive without malignant tumor after 52-month follow-up. Our case provides a new evidence for the existing of intraparenchymal NCAs in deep lymph node and indicates that melanocytes with some atypical features can occur in nodal nevi. Nevus cells in parenchyma connected to those in capsule and trabeculae is a significant clue to distinguish nodal nevi from metastatic melanomas. Additionally, immunohistochemistry and FISH assay are useful in differential diagnosis. This article is protected by copyright. All rights reserved.

Authors+Show Affiliations

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32644206

Citation

Hu, Jue, et al. "Nevus Cell Aggregates Massively Occupying Parenchyma of an External Iliac Lymph Node: a Case Report and Review of the Literature." Journal of Cutaneous Pathology, 2020.
Hu J, Ren M, Cai X, et al. Nevus cell aggregates massively occupying parenchyma of an external iliac lymph node: a case report and review of the literature. J Cutan Pathol. 2020.
Hu, J., Ren, M., Cai, X., Zhang, Y., Lv, J. J., & Kong, Y. Y. (2020). Nevus cell aggregates massively occupying parenchyma of an external iliac lymph node: a case report and review of the literature. Journal of Cutaneous Pathology. https://doi.org/10.1111/cup.13805
Hu J, et al. Nevus Cell Aggregates Massively Occupying Parenchyma of an External Iliac Lymph Node: a Case Report and Review of the Literature. J Cutan Pathol. 2020 Jul 9; PubMed PMID: 32644206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nevus cell aggregates massively occupying parenchyma of an external iliac lymph node: a case report and review of the literature. AU - Hu,Jue, AU - Ren,Min, AU - Cai,Xu, AU - Zhang,Yan, AU - Lv,Jiao-Jie, AU - Kong,Yun-Yi, Y1 - 2020/07/09/ PY - 2020/03/20/received PY - 2020/06/30/revised PY - 2020/07/01/accepted PY - 2020/7/10/entrez KW - FISH KW - congenital nevus KW - immunohistochemistry KW - nevus cell aggregates KW - nodal nevi JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. N2 - We report a case of nevus cell aggregates (NCAs) in an external iliac lymph node from a patient with a compound congenital nevus in the corresponding drainage skin. Melanocytes in parenchyma were in band, nest-like or nodular fashion, and partly continuous with those in capsule and trabeculae. The largest nodule in parenchyma measured 6.5 mm. Melanocytes mostly exhibited benign appearance identical to cutaneous nevus. A few regions abundant in cells displayed atypical features, including increased nucleo-cytoplasmic ratio, small nucleoli, and occasional mitotic figures. Immunohistochemistry showed that melanocytes stained positive for p16, but negative for HMB-45 and nestin. Ki-67 labeling was less than 1% and reticulin mainly surrounded individual melanocytes. Besides, Vysis melanoma Fluorescence in situ hybridization (FISH) plus another 2 probes targeting 9p21(CDKN2A) and 8q24(MYC) showed totally negative. The patient is alive without malignant tumor after 52-month follow-up. Our case provides a new evidence for the existing of intraparenchymal NCAs in deep lymph node and indicates that melanocytes with some atypical features can occur in nodal nevi. Nevus cells in parenchyma connected to those in capsule and trabeculae is a significant clue to distinguish nodal nevi from metastatic melanomas. Additionally, immunohistochemistry and FISH assay are useful in differential diagnosis. This article is protected by copyright. All rights reserved. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/32644206/Nevus_cell_aggregates_massively_occupying_parenchyma_of_an_external_iliac_lymph_node:_a_case_report_and_review_of_the_literature L2 - https://doi.org/10.1111/cup.13805 DB - PRIME DP - Unbound Medicine ER -
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