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Subacute Combined Degeneration of the Spinal Cord

Abstract
Subacute combined degeneration of the spinal cord is a neurological complication of vitamin B12 (cobalamin) deficiency. A deficiency of vitamin B12 can occur as a result of nutritional deficiency, reduced absorption due to altered gastrointestinal anatomy or function, or due to the intake of certain drugs. Subacute combined degeneration is characterized by degeneration of the dorsal columns and the lateral columns of the spinal cord due to demyelination. It commonly presents with sensory deficits, paresthesia, weakness, ataxia, and gait disturbance. In severe untreated cases, it can lead to spasticity and paraplegia. It is crucial to promptly identify and treat vitamin B12 deficiency to prevent the development of this serious neurological complication.

Publisher

StatPearls Publishing
Treasure Island (FL)

Language

eng

PubMed ID

32644742

Citation

Qudsiya Z, De Jesus O: Subacute Combined Degeneration of the Spinal Cord. StatPearls. StatPearls Publishing, 2020, Treasure Island (FL).
Qudsiya Z, De Jesus O. Subacute Combined Degeneration of the Spinal Cord. StatPearls. StatPearls Publishing; 2020.
Qudsiya Z & De Jesus O. (2020). Subacute Combined Degeneration of the Spinal Cord. In StatPearls. Treasure Island (FL): StatPearls Publishing
Qudsiya Z, De Jesus O. Subacute Combined Degeneration of the Spinal Cord. StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
* Article titles in AMA citation format should be in sentence-case
TY - CHAP T1 - Subacute Combined Degeneration of the Spinal Cord BT - StatPearls A1 - Qudsiya,Zainab, AU - De Jesus,Orlando, Y1 - 2020/01// PY - 2020/7/10/pubmed PY - 2020/7/10/medline PY - 2020/7/10/entrez N2 - Subacute combined degeneration of the spinal cord is a neurological complication of vitamin B12 (cobalamin) deficiency. A deficiency of vitamin B12 can occur as a result of nutritional deficiency, reduced absorption due to altered gastrointestinal anatomy or function, or due to the intake of certain drugs. Subacute combined degeneration is characterized by degeneration of the dorsal columns and the lateral columns of the spinal cord due to demyelination. It commonly presents with sensory deficits, paresthesia, weakness, ataxia, and gait disturbance. In severe untreated cases, it can lead to spasticity and paraplegia. It is crucial to promptly identify and treat vitamin B12 deficiency to prevent the development of this serious neurological complication. PB - StatPearls Publishing CY - Treasure Island (FL) UR - https://www.unboundmedicine.com/medline/citation/32644742/StatPearls:_Subacute_Combined_Degeneration_of_the_Spinal_Cord L2 - https://www.ncbi.nlm.nih.gov/books/NBK559316 DB - PRIME DP - Unbound Medicine ER -
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