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Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates.
J Pediatric Infect Dis Soc. 2020 Nov 10; 9(5):630-635.JP

Abstract

Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients are mild or asymptomatic. However, infants have emerged at higher risk of hospitalization and severe outcomes in pediatric coronavirus disease 2019 (COVID-19). We report a case series of 4 full-term neonates hospitalized with fever and found to have SARS-CoV-2 infection with a spectrum of illness severities. Two neonates required admission to the intensive care unit for respiratory insufficiency and end organ involvement. Half of the patients were found to have a coinfection. One neonate received antiviral therapy with remdesivir and is, to our knowledge, the youngest patient to receive this drug for COVID-19. All neonates had favorable outcomes.

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Authors+Show Affiliations

Wardell H
Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA. Harvard Medical School, Boston, Massachusetts, USA.
Campbell JI
Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA. Harvard Medical School, Boston, Massachusetts, USA.
VanderPluym C
Harvard Medical School, Boston, Massachusetts, USA. Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Dixit A
Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.

MeSH

BetacoronavirusBiomarkersBlood Chemical AnalysisCOVID-19COVID-19 TestingClinical Laboratory TechniquesCoronavirus InfectionsElectrocardiographyFeverHumansInfant, NewbornMalePandemicsPneumonia, ViralReverse Transcriptase Polymerase Chain ReactionRisk FactorsSARS-CoV-2Socioeconomic Factors

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32645175

Citation

Wardell, Hanna, et al. "Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates." Journal of the Pediatric Infectious Diseases Society, vol. 9, no. 5, 2020, pp. 630-635.
Wardell H, Campbell JI, VanderPluym C, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates. J Pediatric Infect Dis Soc. 2020;9(5):630-635.
Wardell, H., Campbell, J. I., VanderPluym, C., & Dixit, A. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates. Journal of the Pediatric Infectious Diseases Society, 9(5), 630-635. https://doi.org/10.1093/jpids/piaa084
Wardell H, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates. J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):630-635. PubMed PMID: 32645175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates. AU - Wardell,Hanna, AU - Campbell,Jeffrey I, AU - VanderPluym,Christina, AU - Dixit,Avika, PY - 2020/06/23/received PY - 2020/07/07/accepted PY - 2020/7/10/pubmed PY - 2020/11/18/medline PY - 2020/7/10/entrez KW - COVID-19 KW - SARS-CoV-2 KW - infant KW - neonatal sepsis KW - remdesivir SP - 630 EP - 635 JF - Journal of the Pediatric Infectious Diseases Society JO - J Pediatric Infect Dis Soc VL - 9 IS - 5 N2 - Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients are mild or asymptomatic. However, infants have emerged at higher risk of hospitalization and severe outcomes in pediatric coronavirus disease 2019 (COVID-19). We report a case series of 4 full-term neonates hospitalized with fever and found to have SARS-CoV-2 infection with a spectrum of illness severities. Two neonates required admission to the intensive care unit for respiratory insufficiency and end organ involvement. Half of the patients were found to have a coinfection. One neonate received antiviral therapy with remdesivir and is, to our knowledge, the youngest patient to receive this drug for COVID-19. All neonates had favorable outcomes. SN - 2048-7207 UR - https://www.unboundmedicine.com/medline/citation/32645175/Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Infection_in_Febrile_Neonates_ DB - PRIME DP - Unbound Medicine ER -