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The neuro-immune microenvironment of acupoints-initiation of acupuncture effectiveness.
J Leukoc Biol. 2020 Jul; 108(1):189-198.JL

Abstract

Acupuncture is a centuried and unfading treatment of traditional Chinese medicine, which has been proved to exert curative effects on various disorders. Numerous works have been put in to uncover the effective mechanisms of acupuncture. And the interdependent interaction between acupuncture and acupoint microenvironment is a crucial topic. As a benign minimally invasive stimulation, the insertion and manipulation of needle at acupoint could cause deformation of local connective tissue and secretion of various molecules, such as high mobility group box 1 and ATP. The molecules are secreted into extracellular space and bind to the corresponding receptors thus active NF-κB, MAPK, ERK pathways on mast cells, fibroblasts, keratinocytes, and monocytes/macrophages, among others. This is supposed to trigger following transcription and translation of immune factors and neural active substance, as well as promote the free ion movement (such as Ca2+ influx) and the expansion of blood vessels to recruit more immune cells to acupoint. Finally, acupuncture could enhance network connectivity of local microenvironment at acupoints. The earlier mentioned substances further act on a variety of receptors in local nerve endings, transmitting electrical and biochemical signals to the CNS, and giving full play to the acupuncture action. In conclusion, we portrayed a neuro-immune microenvironment network of acupoints that medicates the acupuncture action, and would lay a foundation for the systematic study of the complex network relationship of acupoints in the future.

Authors+Show Affiliations

Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Academy of Medical Engineering and Translational Medicine, Tianjin University, Nankai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Affiliated Hospital of Municipal Institute of Traditional Chinese Medicine of Changzhi City, Changzhi, Shanxi, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.Acu-moxibustion and Tuina Department, Tianjin University of Traditional Chinese Medicine, Tuanbo, Jinghai, Tianjin, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32645257

Citation

Gong, Yinan, et al. "The Neuro-immune Microenvironment of Acupoints-initiation of Acupuncture Effectiveness." Journal of Leukocyte Biology, vol. 108, no. 1, 2020, pp. 189-198.
Gong Y, Li N, Lv Z, et al. The neuro-immune microenvironment of acupoints-initiation of acupuncture effectiveness. J Leukoc Biol. 2020;108(1):189-198.
Gong, Y., Li, N., Lv, Z., Zhang, K., Zhang, Y., Yang, T., Wang, H., Zhao, X., Chen, Z., Dou, B., Chen, B., Guo, Y., Guo, Y., & Xu, Z. (2020). The neuro-immune microenvironment of acupoints-initiation of acupuncture effectiveness. Journal of Leukocyte Biology, 108(1), 189-198. https://doi.org/10.1002/JLB.3AB0420-361RR
Gong Y, et al. The Neuro-immune Microenvironment of Acupoints-initiation of Acupuncture Effectiveness. J Leukoc Biol. 2020;108(1):189-198. PubMed PMID: 32645257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neuro-immune microenvironment of acupoints-initiation of acupuncture effectiveness. AU - Gong,Yinan, AU - Li,Ningcen, AU - Lv,Zhongxi, AU - Zhang,Kuo, AU - Zhang,Yanfang, AU - Yang,Tao, AU - Wang,Hui, AU - Zhao,Xue, AU - Chen,Zelin, AU - Dou,Baomin, AU - Chen,Bo, AU - Guo,Yongming, AU - Guo,Yi, AU - Xu,Zhifang, PY - 2019/11/01/received PY - 2020/03/29/revised PY - 2020/04/27/accepted PY - 2020/7/10/entrez PY - 2020/7/10/pubmed PY - 2020/7/10/medline KW - acupoints KW - acupuncture KW - microenvironment KW - neuro-immune network SP - 189 EP - 198 JF - Journal of leukocyte biology JO - J. Leukoc. Biol. VL - 108 IS - 1 N2 - Acupuncture is a centuried and unfading treatment of traditional Chinese medicine, which has been proved to exert curative effects on various disorders. Numerous works have been put in to uncover the effective mechanisms of acupuncture. And the interdependent interaction between acupuncture and acupoint microenvironment is a crucial topic. As a benign minimally invasive stimulation, the insertion and manipulation of needle at acupoint could cause deformation of local connective tissue and secretion of various molecules, such as high mobility group box 1 and ATP. The molecules are secreted into extracellular space and bind to the corresponding receptors thus active NF-κB, MAPK, ERK pathways on mast cells, fibroblasts, keratinocytes, and monocytes/macrophages, among others. This is supposed to trigger following transcription and translation of immune factors and neural active substance, as well as promote the free ion movement (such as Ca2+ influx) and the expansion of blood vessels to recruit more immune cells to acupoint. Finally, acupuncture could enhance network connectivity of local microenvironment at acupoints. The earlier mentioned substances further act on a variety of receptors in local nerve endings, transmitting electrical and biochemical signals to the CNS, and giving full play to the acupuncture action. In conclusion, we portrayed a neuro-immune microenvironment network of acupoints that medicates the acupuncture action, and would lay a foundation for the systematic study of the complex network relationship of acupoints in the future. SN - 1938-3673 UR - https://www.unboundmedicine.com/medline/citation/32645257/The_neuro-immune_microenvironment_of_acupoints-initiation_of_acupuncture_effectiveness L2 - https://doi.org/10.1002/JLB.3AB0420-361RR DB - PRIME DP - Unbound Medicine ER -
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