Tags

Type your tag names separated by a space and hit enter

Interstitial fluid-solid interaction within aneurysmal and non-pathological human ascending aortic tissue under translational sinusoidal shear deformation.
Acta Biomater. 2020 Sep 01; 113:452-463.AB

Abstract

The interaction shear force between internal interstitial fluid motion and the solid circumferential-longitudinal medial lamellae helps generate the shear stress involved in dissection of human ascending aorta aneurysmal or non-pathologic tissue. Frequency analysis parameters from the total shear stress versus time response to translational 1 Hz sinusoidal shear deformation over 50 cycles measure the interaction with respect to the three factors: tissue type, sinusoidal deformation amplitude and direction of the shear deformation. Significant 1, 3, and 5 Hz components exist in this order of descending magnitude for shear deformation amplitudes of either 25% or 50% of the specimen length. Evaporation tests indicate that the amount of free water in both aneurysmal and non-pathological tissue is nearly the same. The interstitial fluid-solid interaction under shear deformation is visible in the shoulders of the total shear stress versus time response curve that are caused by the 3 Hz component. During a single deformation cycle, the ratio of the amplitudes of the 3 Hz and the 1 Hz components measures the normalized amount of interaction. Under translational sinusoidal shear deformation at 25% amplitude, this interaction ratio is statistically smaller in non-pathologic than in aneurysmal human ascending aortic tissue in the circumferential direction. The frequency analysis parameters provide evidence that the structural changes in aneurysmal tissue induce an increase in the interstitial fluid-medial solid interaction shear force which contributes to the propensity for aneurysmal rupture. STATEMENT OF

SIGNIFICANCE:

Circumferential shear force between the interstitial fluid and medial lamellae within the human ascending aortic wall is demonstrably greater in aneurysmal than non-pathologic tissue. This force likely increases with medial elastin degeneration and may facilitate the dissection propensity in aneurysmal tissue. The 3 Hz component in frequency analyses of the total shear stress versus time curve produced by 1 Hz sinusoidal translational shear deformation measures the fluid-solid interaction shear force that is otherwise difficult to isolate. This non-standard examination of the interstitial fluid interaction helps clarify clinical mechanical implications of structural differences between aneurysmal and non-pathologic human ascending aortic tissue. The aneurysmal dissection susceptibility does not appear to depend on the amount of interstitial fluid or the wall thickness compared to non-pathologic tissue.

Authors+Show Affiliations

Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA. Electronic address: haslach@umd.edu.Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA.Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32645439

Citation

Haslach, Henry W., et al. "Interstitial Fluid-solid Interaction Within Aneurysmal and Non-pathological Human Ascending Aortic Tissue Under Translational Sinusoidal Shear Deformation." Acta Biomaterialia, vol. 113, 2020, pp. 452-463.
Haslach HW, Gipple J, Harwerth J, et al. Interstitial fluid-solid interaction within aneurysmal and non-pathological human ascending aortic tissue under translational sinusoidal shear deformation. Acta Biomater. 2020;113:452-463.
Haslach, H. W., Gipple, J., Harwerth, J., & Rabin, J. (2020). Interstitial fluid-solid interaction within aneurysmal and non-pathological human ascending aortic tissue under translational sinusoidal shear deformation. Acta Biomaterialia, 113, 452-463. https://doi.org/10.1016/j.actbio.2020.06.045
Haslach HW, et al. Interstitial Fluid-solid Interaction Within Aneurysmal and Non-pathological Human Ascending Aortic Tissue Under Translational Sinusoidal Shear Deformation. Acta Biomater. 2020 Sep 1;113:452-463. PubMed PMID: 32645439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interstitial fluid-solid interaction within aneurysmal and non-pathological human ascending aortic tissue under translational sinusoidal shear deformation. AU - Haslach,Henry W,Jr AU - Gipple,Jenna, AU - Harwerth,Jason, AU - Rabin,Joseph, Y1 - 2020/07/06/ PY - 2020/03/02/received PY - 2020/06/25/revised PY - 2020/06/30/accepted PY - 2020/7/10/pubmed PY - 2020/7/10/medline PY - 2020/7/10/entrez KW - Aneurysmal aorta KW - Human ascending aorta KW - Internal fluid–solid interaction KW - Interstitial fluid KW - Non-pathologic aorta SP - 452 EP - 463 JF - Acta biomaterialia JO - Acta Biomater VL - 113 N2 - The interaction shear force between internal interstitial fluid motion and the solid circumferential-longitudinal medial lamellae helps generate the shear stress involved in dissection of human ascending aorta aneurysmal or non-pathologic tissue. Frequency analysis parameters from the total shear stress versus time response to translational 1 Hz sinusoidal shear deformation over 50 cycles measure the interaction with respect to the three factors: tissue type, sinusoidal deformation amplitude and direction of the shear deformation. Significant 1, 3, and 5 Hz components exist in this order of descending magnitude for shear deformation amplitudes of either 25% or 50% of the specimen length. Evaporation tests indicate that the amount of free water in both aneurysmal and non-pathological tissue is nearly the same. The interstitial fluid-solid interaction under shear deformation is visible in the shoulders of the total shear stress versus time response curve that are caused by the 3 Hz component. During a single deformation cycle, the ratio of the amplitudes of the 3 Hz and the 1 Hz components measures the normalized amount of interaction. Under translational sinusoidal shear deformation at 25% amplitude, this interaction ratio is statistically smaller in non-pathologic than in aneurysmal human ascending aortic tissue in the circumferential direction. The frequency analysis parameters provide evidence that the structural changes in aneurysmal tissue induce an increase in the interstitial fluid-medial solid interaction shear force which contributes to the propensity for aneurysmal rupture. STATEMENT OF SIGNIFICANCE: Circumferential shear force between the interstitial fluid and medial lamellae within the human ascending aortic wall is demonstrably greater in aneurysmal than non-pathologic tissue. This force likely increases with medial elastin degeneration and may facilitate the dissection propensity in aneurysmal tissue. The 3 Hz component in frequency analyses of the total shear stress versus time curve produced by 1 Hz sinusoidal translational shear deformation measures the fluid-solid interaction shear force that is otherwise difficult to isolate. This non-standard examination of the interstitial fluid interaction helps clarify clinical mechanical implications of structural differences between aneurysmal and non-pathologic human ascending aortic tissue. The aneurysmal dissection susceptibility does not appear to depend on the amount of interstitial fluid or the wall thickness compared to non-pathologic tissue. SN - 1878-7568 UR - https://www.unboundmedicine.com/medline/citation/32645439/Interstitial_Fluid-Solid_Interaction_within_Aneurysmal_and_Non-pathological_Human_Ascending_Aortic_Tissue_under_Translational_Sinusoidal_Shear_Deformation DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.