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Eye tracking of smoking-related stimuli in tobacco use disorder: A proof-of-concept study combining attention bias modification with alpha-transcranial alternating current stimulation.
Drug Alcohol Depend. 2020 Sep 01; 214:108152.DA

Abstract

BACKGROUND

Tobacco use disorder (TUD) is characterized by the presence of an attentional bias (AB) towards smoking-related stimuli. We investigated whether combining an AB modification paradigm (ABM) with transcranial alternating current stimulation (tACS) applied over the dorsolateral prefrontal cortex (DLPFC) reduces the AB towards smoking-related stimuli, as well as craving level and impulsive choices.

METHODS

In a sham-controlled, crossover preliminary study, 19 subjects with TUD received two stimulation arms: 1) active tACS (10 Hz, 2 mA, 30 min) combined with ABM and 2) sham tACS combined with ABM, in a randomized order, separated by one week. AB towards smoking cues during passive observation of smoking and neutral cues was assessed with an eye-tracking device and reactions times at a visual-probe task. Craving level was measured with the Questionnaire of Smoking Urges. Impulsive choices were assessed with the delay discounting task.

RESULTS

Active tACS combined with ABM reduced the amount of time spent looking at smoking-related pictures (p = 0.03), prevented the increase of self-reported desire to smoke (p = 0.026), and reduced the proportion of impulsive choices (p = 0.049), compared to sham tACS combined with ABM. No significant effects were reported on other craving dimensions and on AB based on reaction times.

CONCLUSIONS

These preliminary findings suggest that combining tACS with ABM may help smokers who wish to quit by reducing the desire to smoke, attention to smoking-cues, and impulsive decision-making.

Authors+Show Affiliations

Department of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre intégré universitaire en santé et services sociaux de la Capitale-Nationale, 2325 rue de l'Université, Quebec City, QC, G1V 0A6, Canada.Department of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre intégré universitaire en santé et services sociaux de la Capitale-Nationale, 2325 rue de l'Université, Quebec City, QC, G1V 0A6, Canada.Department of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre intégré universitaire en santé et services sociaux de la Capitale-Nationale, 2325 rue de l'Université, Quebec City, QC, G1V 0A6, Canada.Department of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre intégré universitaire en santé et services sociaux de la Capitale-Nationale, 2325 rue de l'Université, Quebec City, QC, G1V 0A6, Canada.Department of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre intégré universitaire en santé et services sociaux de la Capitale-Nationale, 2325 rue de l'Université, Quebec City, QC, G1V 0A6, Canada. Electronic address: shirley.fecteau@fmed.ulaval.ca.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32645683

Citation

Mondino, Marine, et al. "Eye Tracking of Smoking-related Stimuli in Tobacco Use Disorder: a Proof-of-concept Study Combining Attention Bias Modification With Alpha-transcranial Alternating Current Stimulation." Drug and Alcohol Dependence, vol. 214, 2020, p. 108152.
Mondino M, Lenglos C, Cinti A, et al. Eye tracking of smoking-related stimuli in tobacco use disorder: A proof-of-concept study combining attention bias modification with alpha-transcranial alternating current stimulation. Drug Alcohol Depend. 2020;214:108152.
Mondino, M., Lenglos, C., Cinti, A., Renauld, E., & Fecteau, S. (2020). Eye tracking of smoking-related stimuli in tobacco use disorder: A proof-of-concept study combining attention bias modification with alpha-transcranial alternating current stimulation. Drug and Alcohol Dependence, 214, 108152. https://doi.org/10.1016/j.drugalcdep.2020.108152
Mondino M, et al. Eye Tracking of Smoking-related Stimuli in Tobacco Use Disorder: a Proof-of-concept Study Combining Attention Bias Modification With Alpha-transcranial Alternating Current Stimulation. Drug Alcohol Depend. 2020 Sep 1;214:108152. PubMed PMID: 32645683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eye tracking of smoking-related stimuli in tobacco use disorder: A proof-of-concept study combining attention bias modification with alpha-transcranial alternating current stimulation. AU - Mondino,Marine, AU - Lenglos,Christophe, AU - Cinti,Alessandra, AU - Renauld,Emmanuelle, AU - Fecteau,Shirley, Y1 - 2020/07/02/ PY - 2020/03/09/received PY - 2020/05/29/revised PY - 2020/06/26/accepted PY - 2020/7/10/pubmed PY - 2020/7/10/medline PY - 2020/7/10/entrez KW - Attentional bias KW - Craving KW - Delay discounting KW - Drug cues KW - Eye tracking KW - Noninvasive brain stimulation KW - Smoking KW - Transcranial alternating current stimulation SP - 108152 EP - 108152 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 214 N2 - BACKGROUND: Tobacco use disorder (TUD) is characterized by the presence of an attentional bias (AB) towards smoking-related stimuli. We investigated whether combining an AB modification paradigm (ABM) with transcranial alternating current stimulation (tACS) applied over the dorsolateral prefrontal cortex (DLPFC) reduces the AB towards smoking-related stimuli, as well as craving level and impulsive choices. METHODS: In a sham-controlled, crossover preliminary study, 19 subjects with TUD received two stimulation arms: 1) active tACS (10 Hz, 2 mA, 30 min) combined with ABM and 2) sham tACS combined with ABM, in a randomized order, separated by one week. AB towards smoking cues during passive observation of smoking and neutral cues was assessed with an eye-tracking device and reactions times at a visual-probe task. Craving level was measured with the Questionnaire of Smoking Urges. Impulsive choices were assessed with the delay discounting task. RESULTS: Active tACS combined with ABM reduced the amount of time spent looking at smoking-related pictures (p = 0.03), prevented the increase of self-reported desire to smoke (p = 0.026), and reduced the proportion of impulsive choices (p = 0.049), compared to sham tACS combined with ABM. No significant effects were reported on other craving dimensions and on AB based on reaction times. CONCLUSIONS: These preliminary findings suggest that combining tACS with ABM may help smokers who wish to quit by reducing the desire to smoke, attention to smoking-cues, and impulsive decision-making. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/32645683/Eye_tracking_of_smoking-related_stimuli_in_tobacco_use_disorder:_A_proof-of-concept_study_combining_attention_bias_modification_with_alpha-transcranial_alternating_current_stimulation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(20)30317-3 DB - PRIME DP - Unbound Medicine ER -
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