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Rickets in Association with Skin Diseases and Conditions: a Review with Emphasis on Screening and Prevention.
Photodermatol Photoimmunol Photomed. 2020 Jul 09 [Online ahead of print]PP

Abstract

BACKGROUND

Rickets is a common disease worldwide. In the developed world, its prevalence dramatically decreased but still diagnosed in at-risk populations. The skin plays a critical role in vitamin D synthesis. Therefore, several skin diseases, especially keratinization disorders, could lead to impaired vitamin D metabolism and vitamin D deficient rickets.

OBJECTIVE

The article aimed to summarize the current knowledge of skin diseases and conditions associated with rickets.

METHODS

To examine the association between rickets and skin diseases, we performed a systematic review of the literature using PubMed database. The search included studies published from the database inception to August 2019.

RESULTS

A total number of 75 articles were included. Identified conditions associated with rickets were: ichthyosis being a more common skin diseases, alopecia, epidermal and melanocytic nevi, xeroderma pigmentosum, mastocytosis, psoriasis, and atopic dermatitis. Three types of rickets were identified: vitamin D-dependent rickets, hypocalcemic vitamin D-dependent rickets type 2 and hypophosphatemic rickets. Cutaneous skeletal hypophosphatemia syndrome is a newly described and underrecognized condition. It is defined by the association of epidermal or melanocytic nevi, hypophosphatemic rickets and elevated levels of fibroblast growth factor 23. Rickets in patients with ichthyosis was mainly due to impaired ability of ichthyotic skin to synthesize vitamin D, poor UV penetration of the skin caused by keratinocyte proliferation and dark phototype. The latter may be considered a risk factor for rickets in patients with ichthyosis.

CONCLUSION

Despite its rarity, these associations should be properly recognized by dermatologists. Early diagnosis of rickets is important to prevent growth retardation and skeletal deformities.

Authors+Show Affiliations

Department of dermatology, Charles Nicolle Hospital, Tunis, Tunisia. University of Tunis el Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.Department of dermatology, Charles Nicolle Hospital, Tunis, Tunisia. University of Tunis el Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.Department of dermatology, Charles Nicolle Hospital, Tunis, Tunisia. University of Tunis el Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.Department of Rheumatology, Military Hospital, Tunis, Tunisia. University of Tunis el Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.Department of dermatology, Charles Nicolle Hospital, Tunis, Tunisia. University of Tunis el Manar, Faculty of Medicine of Tunis, Tunis, Tunisia.State University of New York Downstate and Veterans Affairs Medical Center, Brooklyn, NY, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32645757

Citation

Litaiem, Noureddine, et al. "Rickets in Association With Skin Diseases and Conditions: a Review With Emphasis On Screening and Prevention." Photodermatology, Photoimmunology & Photomedicine, 2020.
Litaiem N, Chabchoub I, Bacha T, et al. Rickets in Association with Skin Diseases and Conditions: a Review with Emphasis on Screening and Prevention. Photodermatol Photoimmunol Photomed. 2020.
Litaiem, N., Chabchoub, I., Bacha, T., Slouma, M., Zeglaoui, F., & Khachemoune, A. (2020). Rickets in Association with Skin Diseases and Conditions: a Review with Emphasis on Screening and Prevention. Photodermatology, Photoimmunology & Photomedicine. https://doi.org/10.1111/phpp.12590
Litaiem N, et al. Rickets in Association With Skin Diseases and Conditions: a Review With Emphasis On Screening and Prevention. Photodermatol Photoimmunol Photomed. 2020 Jul 9; PubMed PMID: 32645757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rickets in Association with Skin Diseases and Conditions: a Review with Emphasis on Screening and Prevention. AU - Litaiem,Noureddine, AU - Chabchoub,Ines, AU - Bacha,Takwa, AU - Slouma,Maroua, AU - Zeglaoui,Faten, AU - Khachemoune,Amor, Y1 - 2020/07/09/ PY - 2020/7/10/entrez PY - 2020/7/10/pubmed PY - 2020/7/10/medline KW - atopic dermatitis KW - epidermal nevus KW - hypophosphatemia KW - ichthyosis KW - melanocytic nevus KW - rickets KW - xeroderma pigmentosum JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed N2 - BACKGROUND: Rickets is a common disease worldwide. In the developed world, its prevalence dramatically decreased but still diagnosed in at-risk populations. The skin plays a critical role in vitamin D synthesis. Therefore, several skin diseases, especially keratinization disorders, could lead to impaired vitamin D metabolism and vitamin D deficient rickets. OBJECTIVE: The article aimed to summarize the current knowledge of skin diseases and conditions associated with rickets. METHODS: To examine the association between rickets and skin diseases, we performed a systematic review of the literature using PubMed database. The search included studies published from the database inception to August 2019. RESULTS: A total number of 75 articles were included. Identified conditions associated with rickets were: ichthyosis being a more common skin diseases, alopecia, epidermal and melanocytic nevi, xeroderma pigmentosum, mastocytosis, psoriasis, and atopic dermatitis. Three types of rickets were identified: vitamin D-dependent rickets, hypocalcemic vitamin D-dependent rickets type 2 and hypophosphatemic rickets. Cutaneous skeletal hypophosphatemia syndrome is a newly described and underrecognized condition. It is defined by the association of epidermal or melanocytic nevi, hypophosphatemic rickets and elevated levels of fibroblast growth factor 23. Rickets in patients with ichthyosis was mainly due to impaired ability of ichthyotic skin to synthesize vitamin D, poor UV penetration of the skin caused by keratinocyte proliferation and dark phototype. The latter may be considered a risk factor for rickets in patients with ichthyosis. CONCLUSION: Despite its rarity, these associations should be properly recognized by dermatologists. Early diagnosis of rickets is important to prevent growth retardation and skeletal deformities. SN - 1600-0781 UR - https://www.unboundmedicine.com/medline/citation/32645757/Rickets_in_Association_with_Skin_Diseases_and_Conditions:_a_Review_with_Emphasis_on_Screening_and_Prevention L2 - https://doi.org/10.1111/phpp.12590 DB - PRIME DP - Unbound Medicine ER -
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