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A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy.
Molecules. 2020 Jul 07; 25(13)M

Abstract

Combination of chemotherapy and immunotherapy has been a promising strategy in cancer treatment. Polysaccharides from Angelica sinensis (AP), a well-known Chinese herbal medicine, have been proved to have good immunomodulatory activity. In the present study, an enzyme-sensitive tumor-targeting nano drug delivery system (AP-PP-DOX (doxorubicin), PP stood for peptide) was constructed. In this system, Angelica polysaccharides act as not only carriers to targeted delivery of drugs to tumor tissue but also effectors to improve tumor microenvironment and enhance immune function, resulting in synergistic antitumor effect with chemotherapy drugs. The structure of this conjugate was confirmed by FI-IR and 1H-NMR. The particle size and zeta potential of the nanoparticles were 129.00 ± 3.32 nm and -28.45 ± 0.22 mV, respectively. Doxorubicin (DOX) and AP could be quickly released from the AP-PP-DOX under the presence of matrix metalloproteinase 2 (MMP2). The released DOX showed good antitumor efficacy in vitro. The treatment of released AP moiety increased the expression of IL-2, while that of IL-10 was decreased, showing potential in restoring Th1/Th2 immune balance in tumor microenvironment. In a word, this drug delivery system, with specific tissue targeting and tumor microenvironment improvement, will open a new avenue for combination treatment of cancer.

Authors+Show Affiliations

Department of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.Department of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.Department of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.Department of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.Department of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32646040

Citation

Wang, Min-Zhe, et al. "A Nano Drug Delivery System Based On Angelica Sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy." Molecules (Basel, Switzerland), vol. 25, no. 13, 2020.
Wang MZ, He X, Yu Z, et al. A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules. 2020;25(13).
Wang, M. Z., He, X., Yu, Z., Wu, H., & Yang, T. H. (2020). A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules (Basel, Switzerland), 25(13). https://doi.org/10.3390/molecules25133096
Wang MZ, et al. A Nano Drug Delivery System Based On Angelica Sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules. 2020 Jul 7;25(13) PubMed PMID: 32646040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. AU - Wang,Min-Zhe, AU - He,Xin, AU - Yu,Zhe, AU - Wu,Hong, AU - Yang,Tie-Hong, Y1 - 2020/07/07/ PY - 2020/06/02/received PY - 2020/06/30/revised PY - 2020/07/04/accepted PY - 2020/7/11/entrez PY - 2020/7/11/pubmed PY - 2021/2/26/medline KW - Angelica sinensis polysaccharide KW - doxorubicin KW - enzymes sensitive drug delivery KW - synergistic therapy JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 13 N2 - Combination of chemotherapy and immunotherapy has been a promising strategy in cancer treatment. Polysaccharides from Angelica sinensis (AP), a well-known Chinese herbal medicine, have been proved to have good immunomodulatory activity. In the present study, an enzyme-sensitive tumor-targeting nano drug delivery system (AP-PP-DOX (doxorubicin), PP stood for peptide) was constructed. In this system, Angelica polysaccharides act as not only carriers to targeted delivery of drugs to tumor tissue but also effectors to improve tumor microenvironment and enhance immune function, resulting in synergistic antitumor effect with chemotherapy drugs. The structure of this conjugate was confirmed by FI-IR and 1H-NMR. The particle size and zeta potential of the nanoparticles were 129.00 ± 3.32 nm and -28.45 ± 0.22 mV, respectively. Doxorubicin (DOX) and AP could be quickly released from the AP-PP-DOX under the presence of matrix metalloproteinase 2 (MMP2). The released DOX showed good antitumor efficacy in vitro. The treatment of released AP moiety increased the expression of IL-2, while that of IL-10 was decreased, showing potential in restoring Th1/Th2 immune balance in tumor microenvironment. In a word, this drug delivery system, with specific tissue targeting and tumor microenvironment improvement, will open a new avenue for combination treatment of cancer. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/32646040/A_Nano_Drug_Delivery_System_Based_on_Angelica_sinensis_Polysaccharide_for_Combination_of_Chemotherapy_and_Immunotherapy. L2 - https://www.mdpi.com/resolver?pii=molecules25133096 DB - PRIME DP - Unbound Medicine ER -