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Perceptual metacognition of human faces is causally supported by function of the lateral prefrontal cortex.
Commun Biol. 2020 07 09; 3(1):360.CB

Abstract

Metacognitive awareness-the ability to know that one is having a particular experience-is thought to guide optimal behavior, but its neural bases continue to be the subject of vigorous debate. Prior work has identified correlations between perceptual metacognitive ability and the structure and function of lateral prefrontal cortex (LPFC); however, evidence for a causal role of this region in promoting metacognition is controversial. Moreover, whether LPFC function promotes metacognitive awareness of perceptual and emotional features of complex, yet ubiquitous face stimuli is unknown. Here, using model-based analyses following a causal intervention to LPFC in humans, we demonstrate that LPFC function promotes metacognitive awareness of the orientation of faces-although not of their emotional expressions. Collectively, these data support the causal involvement of the prefrontal cortex in metacognitive awareness, and indicate that the role of LPFC in metacognition encompasses perceptual experiences of naturalistic social stimuli.

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Authors+Show Affiliations

Lapate RC
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA. lapate@ucsb.edu. Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA. lapate@ucsb.edu. Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA. lapate@ucsb.edu.
Samaha J
Department of Psychology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Rokers B
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Postle BR
Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Davidson RJ
Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.

MeSH

AdolescentAdultDecision MakingEmotionsFemaleHumansMaleMetacognitionPrefrontal CortexPsychomotor PerformanceVisual PerceptionYoung Adult

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32647260

Citation

Lapate, Regina C., et al. "Perceptual Metacognition of Human Faces Is Causally Supported By Function of the Lateral Prefrontal Cortex." Communications Biology, vol. 3, no. 1, 2020, p. 360.
Lapate RC, Samaha J, Rokers B, et al. Perceptual metacognition of human faces is causally supported by function of the lateral prefrontal cortex. Commun Biol. 2020;3(1):360.
Lapate, R. C., Samaha, J., Rokers, B., Postle, B. R., & Davidson, R. J. (2020). Perceptual metacognition of human faces is causally supported by function of the lateral prefrontal cortex. Communications Biology, 3(1), 360. https://doi.org/10.1038/s42003-020-1049-3
Lapate RC, et al. Perceptual Metacognition of Human Faces Is Causally Supported By Function of the Lateral Prefrontal Cortex. Commun Biol. 2020 07 9;3(1):360. PubMed PMID: 32647260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perceptual metacognition of human faces is causally supported by function of the lateral prefrontal cortex. AU - Lapate,Regina C, AU - Samaha,Jason, AU - Rokers,Bas, AU - Postle,Bradley R, AU - Davidson,Richard J, Y1 - 2020/07/09/ PY - 2019/10/16/received PY - 2020/06/03/accepted PY - 2020/7/11/entrez PY - 2020/7/11/pubmed PY - 2021/6/16/medline SP - 360 EP - 360 JF - Communications biology JO - Commun Biol VL - 3 IS - 1 N2 - Metacognitive awareness-the ability to know that one is having a particular experience-is thought to guide optimal behavior, but its neural bases continue to be the subject of vigorous debate. Prior work has identified correlations between perceptual metacognitive ability and the structure and function of lateral prefrontal cortex (LPFC); however, evidence for a causal role of this region in promoting metacognition is controversial. Moreover, whether LPFC function promotes metacognitive awareness of perceptual and emotional features of complex, yet ubiquitous face stimuli is unknown. Here, using model-based analyses following a causal intervention to LPFC in humans, we demonstrate that LPFC function promotes metacognitive awareness of the orientation of faces-although not of their emotional expressions. Collectively, these data support the causal involvement of the prefrontal cortex in metacognitive awareness, and indicate that the role of LPFC in metacognition encompasses perceptual experiences of naturalistic social stimuli. SN - 2399-3642 UR - https://www.unboundmedicine.com/medline/citation/32647260/Perceptual_metacognition_of_human_faces_is_causally_supported_by_function_of_the_lateral_prefrontal_cortex_ DB - PRIME DP - Unbound Medicine ER -