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Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany.
Eur J Clin Pharmacol. 2020 Jul 10 [Online ahead of print]EJ

Abstract

PURPOSE

Chronic pain is common in the older population and a significant public health concern. However, comprehensive studies on analgesics use in this age group from Germany are scarce. This study aims to give a comprehensive overview on the use of the most common therapeutic groups of analgesics in community-dwelling older adults from Germany.

METHODS

A cross-sectional study was carried out using data from a German cohort of 2038 community-dwelling adults aged 63-89 years. Descriptive statistics and logistic regression models were applied to assess the utilization of analgesics by age, sex, pain severity, pain duration, and locations.

RESULTS

One out of four study participants was suffering from high-intensity or disabling pain. Approximately half of those taking analgesics still reported to suffer from high-intensity or disabling pain. Among analgesics users, occasional non-steroidal anti-inflammatory drugs (NSAIDs) use was the most frequent pain therapy (in 43.6% of users), followed by metamizole (dipyrone) use (16.1%), regular NSAIDs use (12.9%), strong opioids use (12.7%), and weak opioids use (12.0%). In multivariate logistic regression models, higher age, higher pain severity, longer pain duration, abdominal pain, and back pain were statistically significantly associated with opioids use. Metamizole use was also statistically significantly associated with higher pain severity but inversely associated with pain duration.

CONCLUSIONS

A significant number of older German adults are affected by high-intensity and disabling chronic pain despite receiving analgesics. Long-term studies are needed to compare the effectiveness and safety of different treatments for chronic pain in older adults.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Network Aging Research, University of Heidelberg, Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Network Aging Research, University of Heidelberg, Heidelberg, Germany.Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Network Aging Research, University of Heidelberg, Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. b.schoettker@dkfz.de. Network Aging Research, University of Heidelberg, Heidelberg, Germany. b.schoettker@dkfz.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32648116

Citation

Nguyen, Thi Ngoc Mai, et al. "Pain Severity and Analgesics Use in the Community-dwelling Older Population: a Drug Utilization Study From Germany." European Journal of Clinical Pharmacology, 2020.
Nguyen TNM, Laetsch DC, Chen LJ, et al. Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany. Eur J Clin Pharmacol. 2020.
Nguyen, T. N. M., Laetsch, D. C., Chen, L. J., Haefeli, W. E., Meid, A. D., Brenner, H., & Schöttker, B. (2020). Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany. European Journal of Clinical Pharmacology. https://doi.org/10.1007/s00228-020-02954-5
Nguyen TNM, et al. Pain Severity and Analgesics Use in the Community-dwelling Older Population: a Drug Utilization Study From Germany. Eur J Clin Pharmacol. 2020 Jul 10; PubMed PMID: 32648116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany. AU - Nguyen,Thi Ngoc Mai, AU - Laetsch,Dana Clarissa, AU - Chen,Li-Ju, AU - Haefeli,Walter Emil, AU - Meid,Andreas D, AU - Brenner,Hermann, AU - Schöttker,Ben, Y1 - 2020/07/10/ PY - 2020/03/31/received PY - 2020/07/03/accepted PY - 2020/7/11/entrez KW - Analgesics KW - Drug utilization study KW - Metamizole KW - NSAIDs KW - Older adult KW - Opioids JF - European journal of clinical pharmacology JO - Eur. J. Clin. Pharmacol. N2 - PURPOSE: Chronic pain is common in the older population and a significant public health concern. However, comprehensive studies on analgesics use in this age group from Germany are scarce. This study aims to give a comprehensive overview on the use of the most common therapeutic groups of analgesics in community-dwelling older adults from Germany. METHODS: A cross-sectional study was carried out using data from a German cohort of 2038 community-dwelling adults aged 63-89 years. Descriptive statistics and logistic regression models were applied to assess the utilization of analgesics by age, sex, pain severity, pain duration, and locations. RESULTS: One out of four study participants was suffering from high-intensity or disabling pain. Approximately half of those taking analgesics still reported to suffer from high-intensity or disabling pain. Among analgesics users, occasional non-steroidal anti-inflammatory drugs (NSAIDs) use was the most frequent pain therapy (in 43.6% of users), followed by metamizole (dipyrone) use (16.1%), regular NSAIDs use (12.9%), strong opioids use (12.7%), and weak opioids use (12.0%). In multivariate logistic regression models, higher age, higher pain severity, longer pain duration, abdominal pain, and back pain were statistically significantly associated with opioids use. Metamizole use was also statistically significantly associated with higher pain severity but inversely associated with pain duration. CONCLUSIONS: A significant number of older German adults are affected by high-intensity and disabling chronic pain despite receiving analgesics. Long-term studies are needed to compare the effectiveness and safety of different treatments for chronic pain in older adults. SN - 1432-1041 UR - https://www.unboundmedicine.com/medline/citation/32648116/Pain_severity_and_analgesics_use_in_the_community-dwelling_older_population:_a_drug_utilization_study_from_Germany L2 - https://dx.doi.org/10.1007/s00228-020-02954-5 DB - PRIME DP - Unbound Medicine ER -
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