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Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross-sectional study.
J Periodontal Res. 2020 Jul 09 [Online ahead of print]JP

Abstract

OBJECTIVE

The objective of the study is to examine the connection between oral status and the extent of coronary artery disease (CAD), which is diagnosed by angiography.

BACKGROUND

Periodontitis and tooth loss have been linked to atherosclerosis and CAD in previous studies. However, no distinct connection was revealed due to the diversity of the results and the variety of diagnostic methods. To provide a more consistent data pool and stronger evidence, there is a need for studies with standard measurements and diagnostic criteria.

METHODS

309 patients, who consulted to Ankara University, Faculty of Medicine, Department of Cardiology and had coronary angiography, were enrolled to this study. Individuals were grouped based on their coronary angiography results, as CAD (+) (n = 233) and CAD (-) (n = 76). Studied parameters included cardiovascular risk factors, plaque index (PI), remaining teeth count, bleeding on probing (BOP), and probing pocket depth (PPD). Periapical radiographs were taken from teeth with ≥4 mm PPD. Oral status was categorized as periodontally healthy subjects/patients with gingivitis (Group 1), patients with periodontitis (Group 2), and edentulous subjects (Group 3).

RESULTS

PI (P < 0.001), PPD (P = 0.001), BOP (P = 0.004), the number of patients with less than 10 teeth (P = 0.014), and edentulism (P = 0.009) were significantly higher in CAD (+) patients, who were mostly older (P < 0.001) and male (P < 0.001). Multivariate logistic regression analysis revealed that Group 2 (odds ratio = 2.48, 95% confidence interval = 1.24-4.95, P = 0.010) and Group 3 (odds ratio = 2.01, 95% confidence interval = 1.14-5.17, P = 0.040) were highly associated with CAD. Two and three stenosed vessels were significantly higher in Groups 2 and 3 compared to Group 1 (P = 0.003).

CONCLUSIONS

It was found that both edentulism and periodontitis were related to CAD.

Authors+Show Affiliations

Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey.Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.Department of Dento Maxillofacial Radiology, Faculty of Dentistry, Ankara University, Ankara, Turkey.Department of Cardiology, Faculty of Medicine, Ankara University, Ankara, Turkey.Department of Medical Biochemistry, School of Medicine, Acıbadem University, Ankara, Turkey.Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32648271

Citation

Bilgin Çetin, Mehtap, et al. "Relationship of Periodontitis and Edentulism to Angiographically Diagnosed Coronary Artery Disease: a Cross-sectional Study." Journal of Periodontal Research, 2020.
Bilgin Çetin M, Önder C, Orhan K, et al. Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross-sectional study. J Periodont Res. 2020.
Bilgin Çetin, M., Önder, C., Orhan, K., Kumbasar, D., Serdar, M. A., & Ünsal, E. (2020). Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross-sectional study. Journal of Periodontal Research. https://doi.org/10.1111/jre.12782
Bilgin Çetin M, et al. Relationship of Periodontitis and Edentulism to Angiographically Diagnosed Coronary Artery Disease: a Cross-sectional Study. J Periodont Res. 2020 Jul 9; PubMed PMID: 32648271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross-sectional study. AU - Bilgin Çetin,Mehtap, AU - Önder,Canan, AU - Orhan,Kaan, AU - Kumbasar,Deniz, AU - Serdar,Muhittin Abdulkadir, AU - Ünsal,Elif, Y1 - 2020/07/09/ PY - 2019/09/02/received PY - 2020/06/01/revised PY - 2020/06/10/accepted PY - 2020/7/11/entrez KW - coronary angiography KW - coronary artery disease KW - edentulism KW - periodontal disease KW - periodontitis JF - Journal of periodontal research JO - J. Periodont. Res. N2 - OBJECTIVE: The objective of the study is to examine the connection between oral status and the extent of coronary artery disease (CAD), which is diagnosed by angiography. BACKGROUND: Periodontitis and tooth loss have been linked to atherosclerosis and CAD in previous studies. However, no distinct connection was revealed due to the diversity of the results and the variety of diagnostic methods. To provide a more consistent data pool and stronger evidence, there is a need for studies with standard measurements and diagnostic criteria. METHODS: 309 patients, who consulted to Ankara University, Faculty of Medicine, Department of Cardiology and had coronary angiography, were enrolled to this study. Individuals were grouped based on their coronary angiography results, as CAD (+) (n = 233) and CAD (-) (n = 76). Studied parameters included cardiovascular risk factors, plaque index (PI), remaining teeth count, bleeding on probing (BOP), and probing pocket depth (PPD). Periapical radiographs were taken from teeth with ≥4 mm PPD. Oral status was categorized as periodontally healthy subjects/patients with gingivitis (Group 1), patients with periodontitis (Group 2), and edentulous subjects (Group 3). RESULTS: PI (P < 0.001), PPD (P = 0.001), BOP (P = 0.004), the number of patients with less than 10 teeth (P = 0.014), and edentulism (P = 0.009) were significantly higher in CAD (+) patients, who were mostly older (P < 0.001) and male (P < 0.001). Multivariate logistic regression analysis revealed that Group 2 (odds ratio = 2.48, 95% confidence interval = 1.24-4.95, P = 0.010) and Group 3 (odds ratio = 2.01, 95% confidence interval = 1.14-5.17, P = 0.040) were highly associated with CAD. Two and three stenosed vessels were significantly higher in Groups 2 and 3 compared to Group 1 (P = 0.003). CONCLUSIONS: It was found that both edentulism and periodontitis were related to CAD. SN - 1600-0765 UR - https://www.unboundmedicine.com/medline/citation/32648271/Relationship_of_periodontitis_and_edentulism_to_angiographically_diagnosed_coronary_artery_disease:_A_cross-sectional_study L2 - https://doi.org/10.1111/jre.12782 DB - PRIME DP - Unbound Medicine ER -
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