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Shared and specific patterns of dynamic functional connectivity variability of striato-cortical circuitry in unmedicated bipolar and major depressive disorders.
Psychol Med. 2020 Jul 10 [Online ahead of print]PM

Abstract

BACKGROUND

Accumulating studies have found structural and functional abnormalities of the striatum in bipolar disorder (BD) and major depressive disorder (MDD). However, changes in intrinsic brain functional connectivity dynamics of striato-cortical circuitry have not been investigated in BD and MDD. This study aimed to investigate the shared and specific patterns of dynamic functional connectivity (dFC) variability of striato-cortical circuitry in BD and MDD.

METHODS

Brain resting-state functional magnetic resonance imaging data were acquired from 128 patients with unmedicated BD II (current episode depressed), 140 patients with unmedicated MDD, and 132 healthy controls (HCs). Six pairs of striatum seed regions were selected: the ventral striatum inferior (VSi) and the ventral striatum superior (VSs), the dorsal-caudal putamen (DCP), the dorsal-rostral putamen (DRP), and the dorsal caudate and the ventral-rostral putamen (VRP). The sliding-window analysis was used to evaluate dFC for each seed.

RESULTS

Both BD II and MDD exhibited increased dFC variability between the left DRP and the left supplementary motor area, and between the right VRP and the right inferior parietal lobule. The BD II had specific increased dFC variability between the right DCP and the left precentral gyrus compared with MDD and HCs. The MDD had increased dFC variability between the left VSi and the left medial prefrontal cortex compared with BD II and HCs.

CONCLUSIONS

The patients with BD and MDD shared common dFC alteration in the dorsal striatal-sensorimotor and ventral striatal-cognitive circuitries. The patients with MDD had specific dFC alteration in the ventral striatal-affective circuitry.

Authors+Show Affiliations

Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China. Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32648539

Citation

Chen, Guanmao, et al. "Shared and Specific Patterns of Dynamic Functional Connectivity Variability of Striato-cortical Circuitry in Unmedicated Bipolar and Major Depressive Disorders." Psychological Medicine, 2020, pp. 1-10.
Chen G, Chen P, Gong J, et al. Shared and specific patterns of dynamic functional connectivity variability of striato-cortical circuitry in unmedicated bipolar and major depressive disorders. Psychol Med. 2020.
Chen, G., Chen, P., Gong, J., Jia, Y., Zhong, S., Chen, F., Wang, J., Luo, Z., Qi, Z., Huang, L., & Wang, Y. (2020). Shared and specific patterns of dynamic functional connectivity variability of striato-cortical circuitry in unmedicated bipolar and major depressive disorders. Psychological Medicine, 1-10. https://doi.org/10.1017/S0033291720002378
Chen G, et al. Shared and Specific Patterns of Dynamic Functional Connectivity Variability of Striato-cortical Circuitry in Unmedicated Bipolar and Major Depressive Disorders. Psychol Med. 2020 Jul 10;1-10. PubMed PMID: 32648539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shared and specific patterns of dynamic functional connectivity variability of striato-cortical circuitry in unmedicated bipolar and major depressive disorders. AU - Chen,Guanmao, AU - Chen,Pan, AU - Gong,JiaYing, AU - Jia,Yanbin, AU - Zhong,Shuming, AU - Chen,Feng, AU - Wang,Jurong, AU - Luo,Zhenye, AU - Qi,Zhangzhang, AU - Huang,Li, AU - Wang,Ying, Y1 - 2020/07/10/ PY - 2020/7/11/entrez KW - Bipolar disorder KW - dynamic functional connectivity KW - functional magnetic resonance imaging KW - striatum SP - 1 EP - 10 JF - Psychological medicine JO - Psychol Med N2 - BACKGROUND: Accumulating studies have found structural and functional abnormalities of the striatum in bipolar disorder (BD) and major depressive disorder (MDD). However, changes in intrinsic brain functional connectivity dynamics of striato-cortical circuitry have not been investigated in BD and MDD. This study aimed to investigate the shared and specific patterns of dynamic functional connectivity (dFC) variability of striato-cortical circuitry in BD and MDD. METHODS: Brain resting-state functional magnetic resonance imaging data were acquired from 128 patients with unmedicated BD II (current episode depressed), 140 patients with unmedicated MDD, and 132 healthy controls (HCs). Six pairs of striatum seed regions were selected: the ventral striatum inferior (VSi) and the ventral striatum superior (VSs), the dorsal-caudal putamen (DCP), the dorsal-rostral putamen (DRP), and the dorsal caudate and the ventral-rostral putamen (VRP). The sliding-window analysis was used to evaluate dFC for each seed. RESULTS: Both BD II and MDD exhibited increased dFC variability between the left DRP and the left supplementary motor area, and between the right VRP and the right inferior parietal lobule. The BD II had specific increased dFC variability between the right DCP and the left precentral gyrus compared with MDD and HCs. The MDD had increased dFC variability between the left VSi and the left medial prefrontal cortex compared with BD II and HCs. CONCLUSIONS: The patients with BD and MDD shared common dFC alteration in the dorsal striatal-sensorimotor and ventral striatal-cognitive circuitries. The patients with MDD had specific dFC alteration in the ventral striatal-affective circuitry. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/32648539/Shared_and_specific_patterns_of_dynamic_functional_connectivity_variability_of_striato-cortical_circuitry_in_unmedicated_bipolar_and_major_depressive_disorders L2 - https://www.cambridge.org/core/product/identifier/S0033291720002378/type/journal_article DB - PRIME DP - Unbound Medicine ER -
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