Tags

Type your tag names separated by a space and hit enter

Low-Invasive Cell Injection based on Rotational Microrobot.
Adv Biosyst. 2019 07; 3(7):e1800274.AB

Abstract

The advancement of cell injections has created a need for accurate, efficient, and low-invasive injections. However, the conventional approaches to reduce cell damage during penetration, mainly optimization of micropipette tips and vision-based automatic injections, have almost reached the limit. Here, described are the design and implementation of a robotic-aided rotatory microinjection system to reduce cell deformation and penetration force during the injection. The homocentric rotation technology integrates an ultraprecise manipulation system with multiple degrees of freedom, which tremendously diminishes the damage to the cell. Through systematic tests on zebrafish embryo microinjection, compared with traditional straightforward cell injection techniques, the rotary cell injection approach is able to reduce the penetration deformation and force of the specimen up to 30%. This work breaks the performance limit of current microinjection techniques, and paves a new way for the development of low-invasive cell injection systems. It is envisioned that this rotary microrobot system can excavate enormous applications in the field of biomedicine, such as artificial fertilization and gene therapy.

Authors+Show Affiliations

Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China. CityU Shen Zhen Research Institute, Shen Zhen, 518057, China.Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China. CityU Shen Zhen Research Institute, Shen Zhen, 518057, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32648674

Citation

Lu, Haojian, et al. "Low-Invasive Cell Injection Based On Rotational Microrobot." Advanced Biosystems, vol. 3, no. 7, 2019, pp. e1800274.
Lu H, Yang Y, Lin X, et al. Low-Invasive Cell Injection based on Rotational Microrobot. Adv Biosyst. 2019;3(7):e1800274.
Lu, H., Yang, Y., Lin, X., Shi, P., & Shen, Y. (2019). Low-Invasive Cell Injection based on Rotational Microrobot. Advanced Biosystems, 3(7), e1800274. https://doi.org/10.1002/adbi.201800274
Lu H, et al. Low-Invasive Cell Injection Based On Rotational Microrobot. Adv Biosyst. 2019;3(7):e1800274. PubMed PMID: 32648674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-Invasive Cell Injection based on Rotational Microrobot. AU - Lu,Haojian, AU - Yang,Yuanyuan, AU - Lin,Xudong, AU - Shi,Peng, AU - Shen,Yajing, Y1 - 2019/04/01/ PY - 2018/09/18/received PY - 2019/02/25/revised PY - 2020/7/11/entrez PY - 2020/7/11/pubmed PY - 2020/7/11/medline KW - cell injection KW - low invasive KW - robotic aided SP - e1800274 EP - e1800274 JF - Advanced biosystems JO - Adv Biosyst VL - 3 IS - 7 N2 - The advancement of cell injections has created a need for accurate, efficient, and low-invasive injections. However, the conventional approaches to reduce cell damage during penetration, mainly optimization of micropipette tips and vision-based automatic injections, have almost reached the limit. Here, described are the design and implementation of a robotic-aided rotatory microinjection system to reduce cell deformation and penetration force during the injection. The homocentric rotation technology integrates an ultraprecise manipulation system with multiple degrees of freedom, which tremendously diminishes the damage to the cell. Through systematic tests on zebrafish embryo microinjection, compared with traditional straightforward cell injection techniques, the rotary cell injection approach is able to reduce the penetration deformation and force of the specimen up to 30%. This work breaks the performance limit of current microinjection techniques, and paves a new way for the development of low-invasive cell injection systems. It is envisioned that this rotary microrobot system can excavate enormous applications in the field of biomedicine, such as artificial fertilization and gene therapy. SN - 2366-7478 UR - https://www.unboundmedicine.com/medline/citation/32648674/Low-Invasive_Cell_Injection_based_on_Rotational_Microrobot DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.