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Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design.
Adv Biosyst. 2019 06; 3(6):e1800311.AB

Abstract

Life implies motion. In cells, protein-based active molecular machines drive cell locomotion and intracellular transport, control cell shape, segregate genetic material, and split a cell in two parts. Key players among molecular machines driving these various cell functions are the cytoskeleton and motor proteins that convert chemical bound energy into mechanical work. Findings over the last decades in the field of in vitro reconstitutions of cytoskeletal and motor proteins have elucidated mechanistic details of these active protein systems. For example, a complex spatial and temporal interplay between the cytoskeleton and motor proteins is responsible for the translation of chemically bound energy into (directed) movement and force generation, which eventually governs the emergence of complex cellular functions. Understanding these mechanisms and the design principles of the cytoskeleton and motor proteins builds the basis for mimicking fundamental life processes. Here, a brief overview of actin, prokaryotic actin analogs, and motor proteins and their potential role in the design of a minimal cell from the bottom-up is provided.

Authors+Show Affiliations

Department of Systems and Synthetic Microbiology, Max Planck Institute for Terrestrial Microbiology & LOEWE Center for Synthetic Microbiology (Synmikro), D-35043, Marburg, Germany.Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry , Am Klopferspitz 18, D-82152, Martinsried, Germany.Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry , Am Klopferspitz 18, D-82152, Martinsried, Germany.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32648711

Citation

Hürtgen, Daniel, et al. "Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design." Advanced Biosystems, vol. 3, no. 6, 2019, pp. e1800311.
Hürtgen D, Vogel SK, Schwille P. Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design. Adv Biosyst. 2019;3(6):e1800311.
Hürtgen, D., Vogel, S. K., & Schwille, P. (2019). Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design. Advanced Biosystems, 3(6), e1800311. https://doi.org/10.1002/adbi.201800311
Hürtgen D, Vogel SK, Schwille P. Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design. Adv Biosyst. 2019;3(6):e1800311. PubMed PMID: 32648711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytoskeletal and Actin-Based Polymerization Motors and Their Role in Minimal Cell Design. AU - Hürtgen,Daniel, AU - Vogel,Sven Kenjiro, AU - Schwille,Petra, Y1 - 2019/04/01/ PY - 2018/11/21/received PY - 2019/02/28/revised PY - 2020/7/11/entrez PY - 2020/7/11/pubmed PY - 2020/7/11/medline KW - actin KW - cytoskeleton KW - in vitro reconstitution KW - minimal cell KW - molecular machines KW - molecular motors KW - synthetic biology SP - e1800311 EP - e1800311 JF - Advanced biosystems JO - Adv Biosyst VL - 3 IS - 6 N2 - Life implies motion. In cells, protein-based active molecular machines drive cell locomotion and intracellular transport, control cell shape, segregate genetic material, and split a cell in two parts. Key players among molecular machines driving these various cell functions are the cytoskeleton and motor proteins that convert chemical bound energy into mechanical work. Findings over the last decades in the field of in vitro reconstitutions of cytoskeletal and motor proteins have elucidated mechanistic details of these active protein systems. For example, a complex spatial and temporal interplay between the cytoskeleton and motor proteins is responsible for the translation of chemically bound energy into (directed) movement and force generation, which eventually governs the emergence of complex cellular functions. Understanding these mechanisms and the design principles of the cytoskeleton and motor proteins builds the basis for mimicking fundamental life processes. Here, a brief overview of actin, prokaryotic actin analogs, and motor proteins and their potential role in the design of a minimal cell from the bottom-up is provided. SN - 2366-7478 UR - https://www.unboundmedicine.com/medline/citation/32648711/Cytoskeletal_and_Actin-Based_Polymerization_Motors_and_Their_Role_in_Minimal_Cell_Design DB - PRIME DP - Unbound Medicine ER -
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