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Esophageal physiology-an overview of esophageal disorders from a pathophysiological point of view.
Ann N Y Acad Sci. 2020 Jul 10 [Online ahead of print]AN

Abstract

The esophagus serves the principal purpose of transporting food from the pharynx into the stomach. A complex interplay between nerves and muscle fibers ensures that swallowing takes place as a finely coordinated event. Esophageal function can be tested by a variety of methods, endoscopy, manometry, and reflux monitoring being some of the most important. Regarding pathophysiology, motor disorders, such as achalasia, often cause dysphagia and/or chest pain. Functional esophageal disorders are a heterogeneous group with hypersensitivity as a dominant pathophysiological factor. Gastroesophageal reflux disease often causes symptoms, such as heartburn and regurgitation, and a spectrum of disease, ranging from minimal mucosal damage visible only in the microscope to esophageal ulcers and strictures in the most severe cases. Eosinophilic esophagitis is an immune-mediated condition that can result in significant dysphagia and associated luminal narrowing. In the following, we will provide an overview of the most common esophageal disorders from a combined pathophysiological and clinical view.

Authors+Show Affiliations

Department of Medicine, Aalborg University Hospital, Hobro, Denmark. Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.Department of Medicine, New York University School of Medicine, New York, New York.Division of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.Division of Gastroenterology, Department of Medicine, Stanford University, Stanford, California.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32648992

Citation

Lottrup, Christian, et al. "Esophageal Physiology-an Overview of Esophageal Disorders From a Pathophysiological Point of View." Annals of the New York Academy of Sciences, 2020.
Lottrup C, Khan A, Rangan V, et al. Esophageal physiology-an overview of esophageal disorders from a pathophysiological point of view. Ann N Y Acad Sci. 2020.
Lottrup, C., Khan, A., Rangan, V., & Clarke, J. O. (2020). Esophageal physiology-an overview of esophageal disorders from a pathophysiological point of view. Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.14417
Lottrup C, et al. Esophageal Physiology-an Overview of Esophageal Disorders From a Pathophysiological Point of View. Ann N Y Acad Sci. 2020 Jul 10; PubMed PMID: 32648992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Esophageal physiology-an overview of esophageal disorders from a pathophysiological point of view. AU - Lottrup,Christian, AU - Khan,Abraham, AU - Rangan,Vikram, AU - Clarke,John O, Y1 - 2020/07/10/ PY - 2020/03/31/received PY - 2020/05/25/revised PY - 2020/06/03/accepted PY - 2020/7/11/entrez KW - achalasia KW - eosinophilic esophagitis KW - esophageal physiology KW - functional esophageal disorders KW - reflux disease JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. N2 - The esophagus serves the principal purpose of transporting food from the pharynx into the stomach. A complex interplay between nerves and muscle fibers ensures that swallowing takes place as a finely coordinated event. Esophageal function can be tested by a variety of methods, endoscopy, manometry, and reflux monitoring being some of the most important. Regarding pathophysiology, motor disorders, such as achalasia, often cause dysphagia and/or chest pain. Functional esophageal disorders are a heterogeneous group with hypersensitivity as a dominant pathophysiological factor. Gastroesophageal reflux disease often causes symptoms, such as heartburn and regurgitation, and a spectrum of disease, ranging from minimal mucosal damage visible only in the microscope to esophageal ulcers and strictures in the most severe cases. Eosinophilic esophagitis is an immune-mediated condition that can result in significant dysphagia and associated luminal narrowing. In the following, we will provide an overview of the most common esophageal disorders from a combined pathophysiological and clinical view. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/32648992/Esophageal_physiology-an_overview_of_esophageal_disorders_from_a_pathophysiological_point_of_view L2 - https://doi.org/10.1111/nyas.14417 DB - PRIME DP - Unbound Medicine ER -
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